Fluorescence Approaches for the Characterization of the Peripheral Membrane Binding of Proteins Applied for the Blood Coagulation Protein Prothrombin

2002 ◽  
pp. 225-240
Author(s):  
R. Hutterer ◽  
M. Hof
Keyword(s):  
Blood Coagulation ◽  
Membrane Binding ◽  
Coagulation Protein

Current perspectives in antithrombotic therapy

2001 ◽  
Vol 21 (03) ◽  
pp. 82-96 ◽  
Author(s):  
D. Hoppensteadt ◽  
O. Iqbal ◽  
R. L. Bick ◽  
J. Fareed
Keyword(s):  
Blood Coagulation ◽  
Antithrombotic Therapy ◽  
Thrombotic Event ◽  
The United States ◽  
Vascular Thrombosis ◽  
Common Cause ◽  
Coagulation Protein ◽  
Coronary Events ◽  
Platelet Defects

SummaryThrombotic disorders are the most common cause of death in the United States. About two million individuals die each year from an arterial or venous thrombosis or related disorders. About 80% to 90% of all cases of thrombosis can now be defined with respect to cause. Of these, over 50% occur in patients who harbor a congenital or acquired blood coagulation protein or platelet defect which caused the thrombotic event. It is obviously of major importance to define those individuals harboring such a defect as this allows: 1) appropriate antithrombotic therapy to decrease risks of recurrence; 2) determination of the length of time the patient must remain on therapy for secondary prevention; and 3) allow for testing of family members of those harboring a blood coagulation protein or platelet defect which is hereditary (about 50% of all coagulation and platelet defects mentioned above). Aside from mortality, significant additional morbidity occurs from both arterial or venous thrombotic events, including, but not limited to paralysis (non-fatal thrombotic stroke), cardiac disability (repeated coronary events), loss of vision (retinal vascular thrombosis), fetal waste syndrome (placental vascular thrombosis), stasis ulcers and other manifestations of post-phlebitic syndrome, etc.

Characterization of the Membrane Binding Mode of the C2 Domain of PKCε†

Biochemistry ◽  
2003 ◽  
Vol 42 (40) ◽  
pp. 11661-11668 ◽  
Author(s):  
Senena Corbalán-Garcia ◽  
Susana Sánchez-Carrillo ◽  
Josefa García-García ◽  
Juan C. Gómez-Fernández
Keyword(s):  
Membrane Binding ◽  
Binding Mode ◽  
C2 Domain

Characterization of neurocalcin delta membrane binding by biophysical methods

2019 ◽  
Vol 174 ◽  
pp. 291-299 ◽  
Author(s):  
Emmanuelle Hoareau ◽  
Nicolas Belley ◽  
Kristina Klinker ◽  
Bernard Desbat ◽  
Élodie Boisselier
Keyword(s):  
Membrane Binding

Characterization of snake venom components acting on blood coagulation and platelet function

Toxicon ◽  
1992 ◽  
Vol 30 (9) ◽  
pp. 945-966 ◽  
Author(s):  
Chaoho Ouyang ◽  
Che-Ming Teng ◽  
Tur-Fu Huang
Keyword(s):  
Blood Coagulation ◽  
Snake Venom ◽  
Platelet Function

Changes in the Factor VIII C2 domain upon membrane binding determined by hydrogen–deuterium exchange MS

2014 ◽  
Vol 461 (3) ◽  
pp. 443-451 ◽  
Author(s):  
Dionysios Pantazatos ◽  
Christopher R. Gessner ◽  
Virgil L. Woods ◽  
Gary E. Gilbert
Keyword(s):  
Factor Viii ◽  
Blood Coagulation ◽  
Membrane Binding ◽  
Coagulation Factor ◽  
Coagulation Factor Viii ◽  
Hydrogen Deuterium Exchange ◽  
Factor Ixa ◽  
Hydrogen Deuterium ◽  
Binding Peptides ◽  
Blood Coagulation Factor Viii

Blood coagulation Factor VIII binds to a membrane in order to function as a cofactor for Factor IXa, preventing haemophilia. The present study indicates that membrane-binding peptides of Factor VIII are largely protected from water exposure, indicating that they become immersed in the membrane.

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