LAP (NF-IL6) Modulates Hepatoma Cell Proliferation

Tumor Biology ◽  
1996 ◽  
pp. 1-3
Author(s):  
Martina Buck ◽  
Mario Chojkier
Keyword(s):  
Cell Proliferation ◽  
Hepatoma Cell

Antisense oligonucleotides against aldehyde dehydrogenase 3 inhibit hepatoma cell proliferation by affecting MAP kinases

2003 ◽  
Vol 143-144 ◽  
pp. 37-43 ◽  
Author(s):  
Giuliana Muzio ◽  
Antonella Trombetta ◽  
Germana Martinasso ◽  
Rosa A Canuto ◽  
Marina Maggiora
Keyword(s):  
Cell Proliferation ◽  
Aldehyde Dehydrogenase ◽  
Antisense Oligonucleotides ◽  
Map Kinases ◽  
Hepatoma Cell

Insulin-like growth factor-I stimulates H4II rat hepatoma cell proliferation: Dominant role of PI-3′K/Akt signaling

2006 ◽  
Vol 312 (7) ◽  
pp. 1142-1152 ◽  
Author(s):  
Catherine Alexia ◽  
Pascal Fourmatgeat ◽  
Danièle Delautier ◽  
André Groyer
Keyword(s):  
Cell Proliferation ◽  
Growth Factor ◽  
Dominant Role ◽  
Hepatoma Cell ◽  
Akt Signaling ◽  
Insulin Like Growth Factor ◽  
Factor I ◽  
Growth Factor I ◽  
Rat Hepatoma

scholarly journals miR-34a Inhibits Cell Proliferation by Targeting SATB2 in Hepatocellular Carcinoma

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Gang Wu ◽  
Zhixi Li ◽  
Youyu Wang ◽  
Xueming Ju ◽  
Rui Huang
Keyword(s):  
Hepatocellular Carcinoma ◽  
Cell Proliferation ◽  
Hepg2 Cells ◽  
Hepatoma Cell ◽  
Luciferase Reporter ◽  
Hepatoma Cell Line ◽  
Novel Therapy ◽  
The Third ◽  
Direct Target

Hepatocellular carcinoma (HCC) is the most common type of malignancy of the liver and has been reported as the third most frequent cause of cancer associated death worldwide. Accumulating evidence showed that the expression of miR-34a was abnormal in HCC patients; however, the role of miR-34a in HCC is not clear. In this study, we have observed low expression of the miR-34a in both HCC tissues and hepatoma cell line as compared to normal control. Further to investigate the role of miR-34a in HCC development, HepG2 cells were transfected with miR-34a mimic. Following transfection, miR-34a expression was significantly increased, which further repressed proliferation of HepG2 cells. Bioinformatics, Luciferase Reporter, RT-qPCR, and western blotting assays indicated that special AT-rich sequence-binding protein-2 (SATB2) is a direct target of miR-34a in HCC cells. There was a negative correlation between the expression levels of SATB2 and miR-34a. Investigation into the molecular mechanism indicated that miR-34a regulated cell proliferation through inhibiting SATB2. Therefore, the results of the present study may improve understanding regarding the role of miR-34a in regulating cell proliferation and contribute to the development of novel therapy of HCC.

scholarly journals Alendronate-anchored PEGylation of ceria nanoparticles promotes human hepatoma cell proliferation via AKT/ERK signaling pathways

2017 ◽  
Vol 6 (2) ◽  
pp. 374-381 ◽  
Author(s):  
Heng Cheng ◽  
Zhong-Li Liao ◽  
Lin-Hong Ning ◽  
Hong-Yan Chen ◽  
Shan-Shan Wei ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Signaling Pathways ◽  
Hepatoma Cell ◽  
Erk Signaling ◽  
Ceria Nanoparticles ◽  
Human Hepatoma ◽  
Human Hepatoma Cell
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