Exercise-Induced Changes in Gonadotropin Secretion Patterns: A Possible Mechanism for Menstrual Cycle Disturbances

1985 ◽  
pp. 10-19
Author(s):  
H. A. Keizer
Keyword(s):  
Menstrual Cycle ◽  
Gonadotropin Secretion ◽  
Exercise Induced ◽  
Induced Changes

The influence of vigorous aerobic exercise on serum brain-derived neurotrophic factor and estradiol in young, healthy women as a function of the menstrual cycle

2021 ◽  
Author(s):  
Sarah Ahmad ◽  
Rodney Hansen ◽  
Matthew Schmolesky
Keyword(s):  
Menstrual Cycle ◽  
Aerobic Exercise ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor ◽  
Cycle Exercise ◽  
Acute Bout ◽  
Healthy Women ◽  
Exercise Induced ◽  
Induced Changes ◽  
Serum Bdnf

AbstractResearch suggests strong inter-relationships between physical exercise, levels of brain-derived neurotrophic factor (BDNF), levels of estrogen, and the menstrual cycle, and yet no single study has examined these factors collectively in humans. The current study assessed the effect of an acute bout of vigorous aerobic exercise (20 minutes of stationary cycling at 80% of heart rate reserve) on serum BDNF and estradiol in healthy, eumenorrheic women, ages 18-28. In addition, this study determined whether basal BDNF or the exercise-induced increase in BDNF varies throughout the menstrual cycle. Thirty-four subjects were assigned to an experimental (n = 27) or control condition (n = 7). Exercise transiently increased both estradiol (51.2%) and BDNF (23.6%), and basal levels of BDNF and estradiol predicted the magnitude of the exercise-induced increases. Basal BDNF did not vary significantly throughout the menstrual cycle. Exercise-induced changes in BDNF did not correlate with menstrual cycle day or basal estradiol. Basal estradiol and basal BDNF showed a marginally significant positive correlation. Taken together, these results indicate that brief, vigorous aerobic exercise is sufficient to elevate both BDNF and estradiol in healthy women and that the menstrual cycle dramatically influences the magnitude of exercise-induced changes in estradiol, but not BDNF

scholarly journals Exercise-induced changes in circulating growth factors with cyclic variation in plasma estradiol in women

1997 ◽  
Vol 82 (6) ◽  
pp. 1946-1951 ◽  
Author(s):  
Mette Hornum ◽  
Dan M. Cooper ◽  
Jo Anne Brasel ◽  
Alina Bueno ◽  
Kathy E. Sietsema
Keyword(s):  
Growth Factors ◽  
Menstrual Cycle ◽  
Follicular Phase ◽  
Cyclic Variation ◽  
Gh Secretion ◽  
Plasma Estradiol ◽  
Igf I ◽  
Exercise Induced ◽  
Plasma Gh ◽  
Induced Changes

Hornum, Mette, Dan M. Cooper, Jo Anne Brasel, Alina Bueno, and Kathy E. Sietsema. Exercise-induced changes in circulating growth factors and cyclic variation in plasma estradiol in women. J. Appl. Physiol. 82(6): 1946–1951, 1997.—The effect of 10 min of high-intensity cycling exercise on circulating growth hormone (GH), insulin-like growth factors I and II (IGF-I and -II), and insulin-like growth factor binding protein 3 (IGF BP-3) was studied in nine eumenorrheic women (age 19–48 yr) at two different phases of the menstrual cycle. Tests were performed on separate mornings corresponding to the follicular phase and to the periovulatory phase of the menstrual cycle, during which plasma levels of endogenous estradiol (E2) were relatively low (272 ± 59 pmol/l) and high (1,112 ± 407 pmol/l), respectively. GH increased significantly in response to exercise under both E2conditions. Plasma GH before exercise (2.73 ± 2.48 vs. 1.71 ± 2.09 μg/l) and total GH over 10 min of exercise and 1-h recovery (324 ± 199 vs. 197 ± 163 ng) were both significantly greater for periovulatory phase than for follicular phase studies. IGF-I, but not IGF-II, increased acutely after exercise. IGF BP-3, assayed by radioimmunoassay, was not significantly different at preexercise, end exercise, or at 30-min recovery time points and was not different between the two study days. When assayed by Western blot, however, there was a significant increase in IGF BP-3 30 min after exercise for the periovulatory study. These findings indicate that the modulation of GH secretion associated with menstrual cycle variations in circulating E2affects GH measured after exercise, at least in part, by an increase in baseline levels. The acute increase in IGF-I induced by exercise appears to be independent of the GH response and is not affected by menstrual cycle timing.

Effects of menstrual cycle on metabolic responses to exercise

1983 ◽  
Vol 55 (5) ◽  
pp. 1506-1513 ◽  
Author(s):  
A. Bonen ◽  
F. J. Haynes ◽  
W. Watson-Wright ◽  
M. M. Sopper ◽  
G. N. Pierce ◽  
...  
Keyword(s):  
Menstrual Cycle ◽  
Luteal Phase ◽  
Vo2 Max ◽  
Hormonal Responses ◽  
Group A ◽  
Two Phases ◽  
Exercise Induced ◽  
Induced Changes ◽  
And Control ◽  
Glucose Group

Selected substrate and hormonal responses to exercise were compared in two phases of the menstrual cycle. Exercise-induced changes in substrate [glucose, lactate, free fatty acids (FFA), glycerol] and hormonal patterns [luteinizing hormone (LH), follicle-stimulating hormone (FSH), insulin, progesterone (P), growth hormone (GH), cortisol] were compared in the follicular and luteal phases of the menstrual cycle in 24-h-fasted (n = 5), glucose-loaded (n = 6; 1.50 g/kg, 20% solution), and control subjects (n = 8). A treadmill walk was maintained for 60 min (30 min, 40% VO2 max; 30 min, 80% VO2 max). Blood samples were obtained 5 min before, 15, 30, 45, and 60 min during, and 30 min after exercise. In the glucose group a blood sample was also taken 20 min before exercise, and glucose was ingested 15 min before exercise. Within each nutritional group the metabolic and endocrine responses to exercise were similar in the two phases for glucose, lactate, glycerol, LH, FSH, and cortisol (P greater than 0.05). In the glucose group the FFA response was lower in the luteal phase (P less than 0.05). In the fasted subjects insulin and GH responses were elevated in the luteal phase (P less than 0.05). P responses in the control and glucose groups were markedly greater in the luteal phase (P less than 0.05). In the fasted subjects no alteration in P occurred in either phase (P less than 0.05), and the LH concentration was lower in these subjects relative to the control groups (P less than 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

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