Impact of Parenteral Cephalosporins on Human Oropharyngeal and Faecal Flora

Author(s):  
J. C. Pechère
Keyword(s):  
2009 ◽  
Vol 11 (3) ◽  
pp. 577-588 ◽  
Author(s):  
Jonathan C. Banks ◽  
S. Craig Cary ◽  
Ian D. Hogg

1991 ◽  
Vol 106 (3) ◽  
pp. 513-521 ◽  
Author(s):  
B. C. Meijer ◽  
G. J. Kootstra ◽  
D. G. Geertsma ◽  
M. H. F. Wilkinson

SUMMARYIn order to elucidate the effect of ceftriaxone therapy on the morphology of gut microflora, 11 human volunteers were treated with ceftriaxone, 1 g daily, given intramuscularly in one dose. Treatment continued for 5 days. Faecal microflora was analysed by digital image processing before, during and after the treatment period.We derived simple numerical parameters which describe the morphologic composition of the flora. They were significantly influenced by the antibiotic, and returned to their baseline values more than 7 days after treatment was stopped. The procedure holds promise for clinical application.


1995 ◽  
Vol 17 (4) ◽  
pp. 146-149 ◽  
Author(s):  
J.H. Bongers ◽  
F. Franssen ◽  
A.R.W. Elbers ◽  
M.J.M. Tielen

Author(s):  
Aud Krook ◽  
D. Danielsson ◽  
G. Järnerot ◽  
J. Kjellander
Keyword(s):  

Ciprofloxacin ◽  
1986 ◽  
pp. 63-67
Author(s):  
H. A. Holt ◽  
D. A. Lewis ◽  
L. O. White ◽  
S. Y. Bastable ◽  
D. S. Reeves

2019 ◽  
Vol 56 (2) ◽  
pp. 141-145 ◽  
Author(s):  
Maryam GERAVAND ◽  
Parviz FALLAH ◽  
Mojtaba Hedayat YAGHOOBI ◽  
Fatemeh SOLEIMANIFAR ◽  
Malihe FARID ◽  
...  

ABSTRACT BACKGROUND: Colorectal cancer is one of the most commonly diagnosed cancers around the world. One of the factors involved in the development of colorectal cancer is the changes in the normal flora of the intestine. OBJECTIVE: In this study, the mean copy number of Enterococcus faecalis in people with polyps and people with colorectal cancer has been evaluated in comparison with healthy controls. METHODS: In this study, 25 patients with colorectal cancer and 28 patients with intestinal polyps were selected and stool specimens were taken. In addition, 24 healthy individuals were selected as control group. Extraction of bacterial DNA from the stool sample were performed. The molecular methods of PCR for confirmation of standard strain and absolute Real Time PCR (qRT-PCR) method were used to evaluate the number of Enterococcus faecalis in the studied groups. RESULTS: The results of this study indicate that the mean copy number of Enterococcus faecalis in patients with colorectal cancer was 11.2x109 per gram of stool, and in patients with polyps was 9.4x108 per gram of stool. In healthy people, this number was 9x108 per gram of stool. There was a significant difference between the implicit copy numbers in the three groups. (P<0.05). CONCLUSION: Enterococcus faecalis in faecal flora of people with colorectal cancer was significantly higher than those with polyps and healthy people. This could potentially signify the ability of this bacterium to induce colorectal cancer. More studies are needed to prove this theory.


Sign in / Sign up

Export Citation Format

Share Document