A Preliminary Study of Serum Carbamazepine Levels in Healthy Subjects and in Patients with Epilepsy

1975 ◽  
pp. 181-188 ◽  
Author(s):  
R. E. Strandjord ◽  
S. I. Johannessen
Keyword(s):  
Healthy Subjects ◽  
Preliminary Study ◽  
Patients With Epilepsy

Template bleeding time after ingestion of ultra low dosages of acetyl salicylic acid in healthy subjects. Preliminary study

1987 ◽  
Vol 48 (4) ◽  
pp. 501-504 ◽  
Author(s):  
C. Doutremepuich ◽  
D. Pailley ◽  
M.C. Anne ◽  
O. de Séze ◽  
J. Paccalin ◽  
...  
Keyword(s):  
Salicylic Acid ◽  
Healthy Subjects ◽  
Bleeding Time ◽  
Acetyl Salicylic Acid ◽  
Preliminary Study

scholarly journals Effect of real-time ultrasound imaging for biofeedback on trunk muscle contraction in healthy subjects: a preliminary study

2020 ◽  
Author(s):  
Shanshan Lin ◽  
Bo Zhu ◽  
Yiyi Zheng ◽  
Guozhi Huang ◽  
Qing Zeng ◽  
...  
Keyword(s):  
Muscle Contraction ◽  
Real Time ◽  
Ultrasound Imaging ◽  
Healthy Subjects ◽  
Transversus Abdominis ◽  
Trunk Muscles ◽  
Control Group ◽  
Visual Biofeedback ◽  
Preliminary Study ◽  
Experimental Group

Abstract Background: Real-time ultrasound imaging (RUSI) has been increasingly used as a form of biofeedback when instructing and re-training muscle contraction. However, the effectiveness of the RUSI on a single sustained contraction of the lumbar multifidus (LM) and transversus abdominis (TrA) has rarely been reported. This preliminary study aimed to determine if the use of RUSI, as visual biofeedback, could enhance the ability of activation and continuous contraction of the trunk muscles including LM and TrA.Methods: Forty healthy individuals were included and randomly assigned into the experimental group and control group. All subjects performed a preferential activation of the LM and/or TrA (maintained the constraction of LM and/or TrA for 30 seconds and then relaxed for two minutes), while those in the experimental group also received visual feedback provided by RUSI. The thickness of LM and/or TrA at rest and during contraction (Tc-max, T15s, and T30s) were extracted and recorded. The experiment was repeated three times.Results: No significant differences were found in the thickness of LM at rest (P > 0.999), Tc-max (P > 0.999), and T15s (P = 0.414) between the two groups. However, the ability to recruit LM muscle contraction differed between groups at T30s (P = 0.006), with subjects in the experimental group that received visual ultrasound biofeedback maintaining a relative maximum contraction. Besides, no significant differences were found in the TrA muscle thickness at rest (P > 0.999) and Tc-max (P > 0.999) between the two groups. However, significant differences of contraction thickness were found at T15s (P = 0.031) and T30s (P = 0.010) between the two groups during the Abdominal Drawing-in Maneuver (ADIM), with greater TrA muscle contraction thickness in the experimental group.Conclusions: RUSI can be used to provide visual biofeedback, which can promote continuous contraction, and improve the ability to activate the LM and TrA muscles in healthy subjects.

Stereoselective pharmacokinetic analysis of valnoctamide in healthy subjects and in patients with epilepsy*

1997 ◽  
Vol 61 (4) ◽  
pp. 442-449 ◽  
Author(s):  
Shimon Barel ◽  
Boris Yagen ◽  
Volker Schurig ◽  
Stephan Soback ◽  
Francesco Pisani ◽  
...  
Keyword(s):  
Healthy Subjects ◽  
Pharmacokinetic Analysis ◽  
Patients With Epilepsy

Modifying Stride Length in Isolation and in Combination With Foot Progression Angle and Step Width Can Improve Knee Kinetics Related to Osteoarthritis; A Preliminary Study in Healthy Subjects

2020 ◽  
Vol 142 (7) ◽  
Author(s):  
Shannon N. Edd ◽  
Sami Bennour ◽  
Baptiste Ulrich ◽  
Brigitte M. Jolles ◽  
Julien Favre
Keyword(s):  
Repeated Measures ◽  
Healthy Subjects ◽  
Stride Length ◽  
Knee Adduction Moment ◽  
Step Width ◽  
Foot Placement ◽  
Knee Kinetics ◽  
Foot Progression Angle ◽  
Knee Loading ◽  
Preliminary Study

Abstract The purpose of this study was to determine the effects of modifying stride length (SL) on knee adduction and flexion moments, two markers of knee loading associated with medial-compartment knee osteoarthritis (OA) progression. This study also tested if SL modifications, in addition to foot progression angle (FP) and step width (SW) modifications, provide solutions in more subjects for reducing knee adduction moment (KAM) without increasing knee flexion moment (KFM), potentially protecting the joint. Fourteen healthy subjects (six female) were enrolled in this preliminary study. Walking trials were collected first without instructions, and then following foot placement instructions for 50 combinations of SL, FP, and SW modifications. Repeated measures analysis of variance was used to detect group-average effects of footprint modifications on maximum KAM and KFM and on KAM impulse. Subject-specific dose–responses between footprint modifications and kinetics changes were modeled with linear regressions, and the models were used to identify modification solutions, per subject, for various kinetics change conditions. Shorter SL significantly decreased the three kinetics measures (p < 0.01). Potential solutions for 10% reductions in maximum KAM and KAM impulse without increasing maximum KFM were identified for five subjects with FP and SW modifications. A significantly higher proportion of subjects had solutions when adding SL modifications (11 subjects, p = 0.04). In conclusion, SL is a valuable parameter to modify, especially in combination with FP and SW modifications, to reduce markers of medial knee loading. Future work is needed to extend these findings to osteoarthritic knees.

Comparison of Intra-tester Reliability for Measuring Active Lumbar Range of Motion by three Methods in Healthy Subjects: A Preliminary Study

2013 ◽  
Vol 13 (3) ◽  
pp. 58-67
Author(s):  
Bundit Prommanon ◽  
Dr.Rungthip Puntumethakul ◽  
Dr.Punnee Puengsuwan ◽  
Dr.Uraiwon Chatchawan ◽  
Dr.Theera Rittitod
Keyword(s):  
Range Of Motion ◽  
Healthy Subjects ◽  
Preliminary Study ◽  
Lumbar Range Of Motion

The relationship between sexuality and temperament in patients with epilepsy

2019 ◽  
Vol 11 (3) ◽  
pp. 255-262
Author(s):  
V. G. Sosnina ◽  
D. M. Saraykin ◽  
L. V. Lipatova
Keyword(s):  
Healthy Subjects ◽  
Social Activity ◽  
Control Group ◽  
Sexual Relations ◽  
Group 4 ◽  
Structural Test ◽  
Social Plasticity ◽  
Psychological Examination ◽  
Patients With Epilepsy ◽  
The Relationship

Aim: to study the relationship between sexuality and temperament in patients with epilepsy.Materials and methods. The study included 102 participants: 52 patients with epilepsy and 50 healthy individuals aged from 19 to 45 years. The psychological examination was based on the I-structural test of Ammon (ISTA), the Structure of temperament questionnaire (STQ) of Rusalov, and a clinical interview.Results. Using the correlation analysis we were able to reveal 9 correlations between the types of sexuality and the temperament characteristics in patients with epilepsy; in subjects of the control group – 4 correlations were found. Thus, in patients with epilepsy, constructive sexuality positively correlated with plasticity, social erginess, and pace, whereas in healthy subjects – with social erginess. In patients with epilepsy, destructive sexuality positively correlated with plasticity, social erginess, and social plasticity; in healthy subjects, destructive sexuality negatively correlated with social erginess. In patients with epilepsy, deficient sexuality negatively correlated with pace, plasticity, and social erginess, whereas in healthy subjects – with plasticity and social plasticity.Conclusion. The study shows that the sexuality in patients with epilepsy is more deterministic than that in the comparison group. In addition, all types of sexuality in these patients correlate with plasticity and social erginess, which suggests that patients with epilepsy can be satisfied with sexual relations, show flexibility and strive for diversity while being flexible and socially active. These correlations can be read vice versa, i.e., striving for diversity and social activity in patients with epilepsy is accompanied by satisfaction with their sexual relations and inclination to experiment. 

Does Valproic Acid/Na Valproate Suppress Auditory Startle Reflex in Patients With Epilepsy?

2017 ◽  
Vol 49 (6) ◽  
pp. 407-413
Author(s):  
Meral E. Kızıltan ◽  
Leyla Köse Leba ◽  
Ayşegül Gündüz ◽  
Nevin Pazarcı ◽  
Çiğdem Özkara ◽  
...  
Keyword(s):  
Valproic Acid ◽  
Startle Response ◽  
Healthy Subjects ◽  
Juvenile Myoclonic Epilepsy ◽  
Myoclonic Epilepsy ◽  
Lower Probability ◽  
Somatosensory Stimulation ◽  
Dopaminergic Transmission ◽  
Auditory Startle Response ◽  
Patients With Epilepsy

Background and Objective. Auditory startle response (ASR) was normal in juvenile myoclonic epilepsy whereas it was suppressed in progressive myoclonic epilepsy. However, both groups were using valproic acid/Na valproate (VPA) in different doses. Therefore, we aimed to analyze whether VPA has an impact on ASR in a cohort of epilepsy. For this purpose, we included patients with epilepsy and analyzed ASR in patients who were using VPA. Patients and Method. We included 51 consecutive patients who had epilepsy and were using VPA between January 2014 and January 2016. Two control groups of 37 epilepsy patients using other antiepileptic drugs (AEDs) and of 25 healthy subjects were also constituted. All participants underwent investigations of ASR and startle response to somatosensory inputs (SSS) under similar conditions. Results. An analysis of patients using VPA, not using VPA and healthy subjects revealed significantly longer latency and lower probability of orbicularis oculi (O.oc) and sternocleidomastoid responses after auditory stimulation, decreased total ASR probability and longer latency of O.oc response after somatosensory stimulation in patient groups compared with healthy subjects. Multivariate analysis showed type of AED had a role in the generation of abnormalities. VPA, carbamazepine, and multiple AED use caused suppression of ASR. Total ASR probability was decreased or O.oc latency got longer with longer duration of VPA use whereas serum VPA level at the time of investigation did not correlate with total ASR probability. Discussion. Both ASR and SSS are suppressed by the effect of VPA, especially in patients using for a long period and in patients using other AEDs with VPA. Given the fact that VPA leads to long-standing synaptic changes of dopaminergic transmission, abnormalities of this network may be the more likely cause.

Sign in / Sign up

Export Citation Format

Share Document