Simulated Head Impacts with Upper Interior Structures Using Rigid and Anatomic Brain Models

1991 ◽  
pp. 333-345 ◽  
Author(s):  
F. DiMasi ◽  
P. Tong ◽  
J. H. Marcus ◽  
H. C. Gabler ◽  
R. H. Eppinger
Keyword(s):  
Head Impacts ◽  
Brain Models

Is it Possible to Protect the Adolescent Brain with Internal Mechanisms from Repetitive Head Impacts: Results from a Phase II Single Cohort, Longitudinal, Self-Control Study

2021 ◽  
Vol 3 (1) ◽  
pp. 56-65 ◽  
Author(s):  
Kelsey Logan ◽  
Weihong Yuan ◽  
Kim D. Barber Foss ◽  
Jed A. Diekfuss ◽  
Christopher A. DiCesare ◽  
...  
Keyword(s):  
Phase Ii ◽  
Self Control ◽  
Head Impacts ◽  
Repetitive Head Impacts ◽  
Control Study ◽  
Single Cohort

scholarly journals Predictive Factors of Kinematics in Traumatic Brain Injury from Head Impacts Based on Statistical Interpretation

2021 ◽  
Author(s):  
Xianghao Zhan ◽  
Yiheng Li ◽  
Yuzhe Liu ◽  
August G. Domel ◽  
Hossein Vahid Alizadeh ◽  
...  
Keyword(s):  
Traumatic Brain Injury ◽  
Brain Injury ◽  
Predictive Factors ◽  
Statistical Interpretation ◽  
Head Impacts

scholarly journals Tau isoforms are differentially expressed across the hippocampus in chronic traumatic encephalopathy and Alzheimer’s disease

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Jonathan D. Cherry ◽  
Camille D. Esnault ◽  
Zachary H. Baucom ◽  
Yorghos Tripodis ◽  
Bertrand R. Huber ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chronic Traumatic Encephalopathy ◽  
Temporal Cortex ◽  
Head Impacts ◽  
Hippocampal Subfields ◽  
Mild Disease ◽  
Tau Isoforms ◽  
Ghost Tangles

AbstractChronic traumatic encephalopathy (CTE) is a progressive neurodegenerative disease, characterized by hyperphosphorylated tau, found in individuals with a history of exposure to repetitive head impacts. While the neuropathologic hallmark of CTE is found in the cortex, hippocampal tau has proven to be an important neuropathologic feature to examine the extent of disease severity. However, the hippocampus is also heavily affected in many other tauopathies, such as Alzheimer’s disease (AD). How CTE and AD differentially affect the hippocampus is unclear. Using immunofluorescent analysis, a detailed histologic characterization of 3R and 4R tau isoforms and their differential accumulation in the temporal cortex in CTE and AD was performed. CTE and AD were both observed to contain mixed 3R and 4R tau isoforms, with 4R predominating in mild disease and 3R increasing proportionally as pathological severity increased. CTE demonstrated high levels of tau in hippocampal subfields CA2 and CA3 compared to CA1. There were also low levels of tau in the subiculum compared to CA1 in CTE. In contrast, AD had higher levels of tau in CA1 and subiculum compared to CA2/3. Direct comparison of the tau burden between AD and CTE demonstrated that CTE had higher tau densities in CA4 and CA2/3, while AD had elevated tau in the subiculum. Amyloid beta pathology did not contribute to tau isoform levels. Finally, it was demonstrated that higher levels of 3R tau correlated to more severe extracellular tau (ghost tangles) pathology. These findings suggest that mixed 3R/4R tauopathies begin as 4R predominant then transition to 3R predominant as pathological severity increases and ghost tangles develop. Overall, this work demonstrates that the relative deposition of tau isoforms among hippocampal subfields can aid in differential diagnosis of AD and CTE, and might help improve specificity of biomarkers for in vivo diagnosis.

scholarly journals Effects of sport-related repetitive subconcussive head impacts on biofluid markers: a scoping review protocol

BMJ Open ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. e046452
Author(s):  
Liivia-Mari Lember ◽  
Michail Ntikas ◽  
Stefania Mondello ◽  
Lindsay Wilson ◽  
Angus Hunter ◽  
...  
Keyword(s):  
Scoping Review ◽  
Unmet Need ◽  
Research Priorities ◽  
Medical Decision ◽  
Cochrane Library ◽  
Eligibility Criteria ◽  
Head Impacts ◽  
Review Protocol ◽  
Ebsco Host ◽  
Clinical Trials Registry

IntroductionSport-related repetitive subconcussive head impacts (RSHIs) are increasingly thought to be associated with adverse long-term outcomes. However, owing to potentially subtle effects, accurate assessment of harm to the brain as a consequence of RSHI is a major challenge and an unmet need. Several studies suggest that biofluid markers can be valuable objective tools to aid the diagnosis and injury characterisation and help in medical decision-making. Still, by and large, the results have been limited, heterogeneous and inconsistent. The main aims of this scoping review are therefore (1) to systematically examine the extent, nature and quality of available evidence from studies investigating effects of RSHI on fluid biomarkers and (2) to formulate guidelines and identify gaps with the aim to inform future clinical studies and the development of research priorities.Methods and analysesWe will use a comprehensive search strategy to retrieve all available and relevant articles in the literature. The following electronic databases will be systematically searched: MEDLINE (EBSCO host; from 1809 to 2020); Scopus (from 1788 to 2020); SPORTDiscus (from 1892 to 2020); CINAHL Complete (from 1937 to 2020); PsycINFO (from 1887 to 2020); Cochrane Library (to 2020); OpenGrey (to 2020); ClinicalTrials.gov (to 2020) and WHO International Clinical Trials Registry Platform (to 2020). We will consider primarily biomedical studies evaluating the biofluid markers following RSHI. Two independent reviewers will screen articles for inclusion using predefined eligibility criteria and extract data of retained articles. Disagreements will be resolved through consensus or arbitrated by a third reviewer if necessary. Data will be reported qualitatively given the heterogeneity of the included studies. In synthesising the evidence, we will structure results by markers, sample types, outcomes, sport and timepoints.Ethics and disseminationEthics approval is not required. We will submit results for peer-review publication, and present at relevant conferences.

On-Field Performance of an Instrumented Mouthguard for Detecting Head Impacts in American Football

2020 ◽  
Vol 48 (11) ◽  
pp. 2599-2612
Author(s):  
Lee F. Gabler ◽  
Samuel H. Huddleston ◽  
Nathan Z. Dau ◽  
David J. Lessley ◽  
Kristy B. Arbogast ◽  
...  
Keyword(s):  
Field Performance ◽  
American Football ◽  
Head Impacts

scholarly journals Field-based measures of head impacts in high school football athletes

2012 ◽  
Vol 24 (6) ◽  
pp. 702-708 ◽  
Author(s):  
Steven P. Broglio ◽  
James T. Eckner ◽  
Jeffery S. Kutcher
Keyword(s):  
High School ◽  
High School Football ◽  
Head Impacts

scholarly journals Can helmet design reduce the risk of concussion in football?

2014 ◽  
Vol 120 (4) ◽  
pp. 919-922 ◽  
Author(s):  
Steven Rowson ◽  
Stefan M. Duma ◽  
Richard M. Greenwald ◽  
Jonathan G. Beckwith ◽  
Jeffrey J. Chu ◽  
...  
Keyword(s):  
Head Impact ◽  
Dartmouth College ◽  
University Of Minnesota ◽  
Head Impacts ◽  
University Of Oklahoma ◽  
Significant Difference ◽  
Rule Changes ◽  
Impact Data ◽  
Collegiate Football ◽  
Helmet Design

Of all sports, football accounts for the highest incidence of concussion in the US due to the large number of athletes participating and the nature of the sport. While there is general agreement that concussion incidence can be reduced through rule changes and teaching proper tackling technique, there remains debate as to whether helmet design may also reduce the incidence of concussion. A retrospective analysis was performed of head impact data collected from 1833 collegiate football players who were instrumented with helmet-mounted accelerometer arrays for games and practices. Data were collected between 2005 and 2010 from 8 collegiate football teams: Virginia Tech, University of North Carolina, University of Oklahoma, Dartmouth College, Brown University, University of Minnesota, Indiana University, and University of Illinois. Concussion rates were compared between players wearing Riddell VSR4 and Riddell Revolution helmets while controlling for the head impact exposure of each player. A total of 1,281,444 head impacts were recorded, from which 64 concussions were diagnosed. The relative risk of sustaining a concussion in a Revolution helmet compared with a VSR4 helmet was 46.1% (95% CI 28.1%–75.8%). When controlling for each player's exposure to head impact, a significant difference was found between concussion rates for players in VSR4 and Revolution helmets (χ2 = 4.68, p = 0.0305). This study illustrates that differences in the ability to reduce concussion risk exist between helmet models in football. Although helmet design may never prevent all concussions from occurring in football, evidence illustrates that it can reduce the incidence of this injury.

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