Thrombin-Antithrombin III Complex and D-Dimer in Neonates

The complex picture of inflammation and coagulation alterations comes to life in acute stroke phases. Increasing evidence points to a strong interaction and extensive crosstalk between the inflammation and coagulation systems: the interest towards this relationship has increased since recent experimental research showed that the early administration of antithrombin III (ATIII) decreases the volume of ischemia in mice and might be neuroprotective, playing an antiinflammatory role. We aimed to establish the extent of the relationship among markers of inflammation (S100B and IL-18) and procoagulant and fibrinolytic markers (ATIII, thrombin-antithrombin III complex (TAT), Fibrin Degradation Products (FDP), D-dimer) in 13 comatose patients affected by focal cerebral ischemia. Plasma levels of TAT, D-dimer and FDP, IL18 and S100B were increased. IL-18 and S100B high serum levels in ischemic patients suggest an early activation of the inflammatory cascade in acute ischemic injury. The basic principles of the interaction between inflammatory and coagulation systems are revised, from the perspective that simultaneous modulation of both coagulation and inflammation, rather than specific therapies aimed at one of these systems could be more successful in stroke therapy.

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D-Dimer and Thrombin/Antithrombin III Complex – Diagnostic Tools in Deep Venous Thrombosis?

Pathophysiology of Haemostasis and Thrombosis ◽

10.1159/000217125 ◽

1994 ◽

Vol 24 (6) ◽

pp. 344-350 ◽

Cited By ~ 1

Author(s):

Lilian Tengborn ◽

Suzanne Palmblad ◽

Josef Wojciechowski ◽

Lars-Erik Peterson ◽

Lennart Stigendal

Keyword(s):

Venous Thrombosis ◽

Deep Venous Thrombosis ◽

Antithrombin Iii ◽

Diagnostic Tools ◽

Thrombin Antithrombin Iii Complex ◽

D Dimer

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Diagnostic Significance of Thrombin-Antithrombin III Complex (TAT) and D-Dimer in Patients With Deep Venous Thrombosis

Japanese Circulation Journal ◽

10.1253/jcj.60.201 ◽

1996 ◽

Vol 60 (4) ◽

pp. 201-206 ◽

Cited By ~ 8

Author(s):

Hiromi Sassa ◽

Takahito Sone ◽

Hideyuki Tsuboi ◽

Junichiro Kondo ◽

Toshitake Yabashi

Keyword(s):

Venous Thrombosis ◽

Deep Venous Thrombosis ◽

Antithrombin Iii ◽

Diagnostic Significance ◽

Thrombin Antithrombin Iii Complex ◽

D Dimer

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Thrombin–antithrombin III complex tests

Journal of Orthopaedic Surgery ◽

10.1177/0170840616684501 ◽

2017 ◽

Vol 25 (1) ◽

pp. 017084061668450 ◽

Cited By ~ 4

Author(s):

Sang Yang Lee ◽

Takahiro Niikura ◽

Takashi Iwakura ◽

Yoshitada Sakai ◽

Ryosuke Kuroda ◽

...

Keyword(s):

Sensitivity And Specificity ◽

Roc Curve ◽

Lower Limb ◽

Antithrombin Iii ◽

Pelvic Fractures ◽

Curve Analysis ◽

Roc Curve Analysis ◽

Optimal Cutoff ◽

Thrombin Antithrombin Iii Complex ◽

D Dimer

Purpose: Patients with fractures of the pelvis and/or lower extremities are at a high risk of developing postoperative venous thromboembolism (VTE). The purpose of this study was to determine whether the thrombin–antithrombin III complex (TAT) tests could be used for postoperative screening of VTE in patients with lower limb or pelvic fractures. Methods: We enrolled 133 patients who underwent surgical treatment for fracture of the pelvis or lower extremities. TAT and D-dimer levels were compared in patients with and without VTE. Receiver operating characteristic (ROC) curve analysis was done and the appropriate TAT and D-dimer cutoff levels were determined for VTE screening. Results: VTE was diagnosed in 41 patients (30.8%). Patients with VTE had significantly higher levels of TAT and D-dimer on postoperative days 1, 3, and 7 than those without VTE, respectively. ROC curve analysis suggested that TAT test at postoperative day 7 had the highest accuracy for predicting postoperative VTE. With the optimal cutoff TAT level of 3.0 ng/mL, sensitivity and specificity were 93.3% and 70.1%, respectively. With the optimal cutoff D-dimer level of 7.4 µg/mL, sensitivity and specificity were 93.3% and 57.0%, respectively. Conclusion: TAT levels measured at postoperative day 7 could be the most useful parameter for screening postoperative VTE. TAT can be used as a screening tool for screening postoperative VTE in patients with lower limb and pelvic fractures.

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The Role of Venom Haemorrhagin in Spontaneous Bleeding in Bothrops jararaca Envenoming

Thrombosis and Haemostasis ◽

10.1055/s-0038-1648475 ◽

1992 ◽

Vol 67 (04) ◽

pp. 484-488 ◽

Cited By ~ 35

Author(s):

A S Kamiguti ◽

F P Rugman ◽

R D G Theakston ◽

F O S Franca ◽

H Ishii ◽

...

Keyword(s):

Antithrombin Iii ◽

Clinical Signs ◽

Endothelial Damage ◽

Vascular Endothelial ◽

Spontaneous Bleeding ◽

Bothrops Jararaca ◽

Thrombin Antithrombin Iii Complex ◽

Very High ◽

D Dimer

SummaryThirty-eight patients bitten by Bothrops jararaca were investigated. Twenty-six had signs of local or systemic haemorrhage. Twenty-two of these had incoagulable blood, and these patients were found to have low fibrinogen levels (mean 0.17 ± 0.03 g/1), thrombocytopenia, very high thrombin-antithrombin III complex (850 ± 184 pg/1) and D-dimer (170 ± 44 μg/ml) antigen levels. Serum venom haemorrhagin levels were significantly higher in patients with clinical signs of haemorrhage (36.4 ± 6.4 ng/ml) than those without (11.7 ± 3.7 ng/ml; p <0.002). Twelve out of 13 patients with thrombocytopenia were bleeding. High levels of thrombomodulin (22.3 ± 1.5 ng/ml) and haemorrhagin (35.7 ± 7.7 ng/ml) were detected in these 12 patients, suggesting vascular endothelial damage. Haemorrhagin levels also correlated inversely with platelet count in these patients. It was concluded that thrombocytopenia is one of the main causes of bleeding inB. jararaca victims, possibly as a result of venom haemorrhagin activity.

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Diphasic Increase in Thrombin-Antithrombin III Complex in Blood from the Internal Jugular Vein Following Severe Head Injury

Thrombosis and Haemostasis ◽

10.1055/s-0038-1642402 ◽

1994 ◽

Vol 71 (01) ◽

pp. 155-157 ◽

Cited By ~ 13

Author(s):

M Suzuki ◽

O Motohashi ◽

A Nishino ◽

V Shiina ◽

K Mizoi ◽

...

Keyword(s):

Head Injury ◽

Internal Jugular Vein ◽

Severe Head Injury ◽

Antithrombin Iii ◽

Jugular Vein ◽

Thrombin Antithrombin Iii Complex

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D-Dimers, Thrombin Antithrombin III Complexes and Prothrombin Fragments 1 + 2: Diagnostic value in Clinically Suspected Deep Vein Thrombosis

Thrombosis and Haemostasis ◽

10.1055/s-0038-1647449 ◽

1991 ◽

Vol 65 (01) ◽

pp. 028-032 ◽

Cited By ~ 105

Author(s):

B Boneu ◽

G Bes ◽

H Pelzer ◽

P Sié ◽

H Boccalon

Keyword(s):

Deep Vein Thrombosis ◽

Antithrombin Iii ◽

High Sensitivity ◽

Diagnostic Value ◽

Predictive Values ◽

Vein Thrombosis ◽

High Negative Predictive Value ◽

Deep Vein ◽

D Dimer ◽

Mercury Strain Gauge

SummaryThis study was performed to determine the accuracy of D-Dimer fibrin derivatives, thrombin-antithrombin III (TAT) complexes and prothrombin fragments 1 + 2 (F 1 + 2) determinations for the diagnosis of deep vein thrombosis (DVT). One hundred and sixteen consecutive patients referred to the angiology unit of our hospital for a clinically suspected DVT were investigated. They were submitted to mercury strain gauge plethysmography and to ultrasonic duplex scanning examination; in cases of inconclusive results or of proximal DVT (n = 35), an ascending phlebography was performed. After these investigations were completed, the diagnosis of DVT was confirmed in 34 and excluded in 82. One half of the patients were already under anticoagulant therapy at the time of investigation. The 3 biological markers were assayed using commercially available ELISA techniques and the D-Dimer was also assayed with a fast latex method. The normal distribution of these markers was established in 40 healthy blood donors. The most accurate assay for the diagnosis of DVT was the D-Dimer ELISA which had both a high sensitivity (94%) and a high negative predictive value (95%). The D-Dirner latex, TAT complexes and F 1 + 2 were far less sensitive and provided negative predictive values which ranged between 78 and 85%. In spite of positive and significant correlations between the levels of ihe 3 markers, their association did not improve their overall accuracy for detecting D\/L Therefore, with the exception of the D-Dimer ELISA, these markers were of little value for the diagnosis of DVT in this specific population.

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Is there a possible role for haemostasis in the development of perigraft reaction complicating the modified Blalock Taussig shunt?

Cardiology in the Young ◽

10.1017/s1047951100009203 ◽

2000 ◽

Vol 10 (3) ◽

pp. 261-264 ◽

Cited By ~ 1

Author(s):

Ulrike Salzer-Muhar ◽

Ingrid Pabinger-Fasching ◽

Sophie Zacherl-Wightman

Keyword(s):

Antithrombin Iii ◽

Unusual Complication ◽

Laboratory Findings ◽

Thrombin Antithrombin Iii Complex ◽

Blalock Taussig Shunt

AbstractThe perigraft reaction is an unusual complication found in patients in whom a modified Blalock Taussig shunt has been created using a polytetrafluoroethylene graft. We found that, in two infants, consistent laboratory findings during such a perigraft reaction were hypofibrinogenemia, increased levels of thrombin-antithrombin III complex, prothrombinfragment 1 and 2 and products of degradation of fibrin. Normalization of the levels of fibrinogen produced resolution of the perigraft reaction.

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