Reduction of HIV Infection that Includes a Delay with Cure Rate During Long Term Treatment: A Mathematical Study

Abstract In recent decades, attention has focused on reducing long-term, treatment-related morbidity and mortality in Hodgkin lymphoma (HL). In the present study, we looked for trends in relative survival for all patients diagnosed with HL in Sweden from 1973-2009 (N = 6949; 3985 men and 2964 women; median age, 45 years) and followed up for death until the end of 2010. Patients were categorized into 6 age groups and 5 calendar periods (1973-1979, 1980-1986, 1987-1994, 1994-2000, and 2001-2009). Relative survival improved in all age groups, with the greatest improvement in patients 51-65 years of age (P < .0005). A plateau in relative survival was observed in patients below 65 years of age during the last calendar period, suggesting a reduced long-term, treatment-related mortality. The 10-year relative survival for patients diagnosed in 2000-2009 was 0.95, 0.96, 0.93, 0.80, and 0.44 for the age groups 0-18, 19-35, 36-50, 51-65, and 66-80, respectively. Therefore, despite progress, age at diagnosis remains an important prognostic factor (P < .0005). Advances in therapy for patients with limited and advanced-stage HL have contributed to an increasing cure rate. In addition, our findings support that long-term mortality of HL therapy has decreased. Elderly HL patients still do poorly, and targeted treatment options associated with fewer side effects will advance the clinical HL field.

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Long-term treatment for lipoatrophy associated or not with HIV infection using ePTFE implants and polyacrylamide gel

Aesthetic Surgery Journal ◽

10.1016/j.asj.2005.09.006 ◽

2005 ◽

Vol 25 (6) ◽

pp. 561-570 ◽

Cited By ~ 5

Author(s):

B MOLE

Keyword(s):

Hiv Infection ◽

Term Treatment ◽

Polyacrylamide Gel ◽

Long Term Treatment

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Clinical Outcomes of Ambulatory Acute Exacerbations of Chronic Bronchitis with Older versus Newer Antimicrobials

Annals of Pharmacotherapy ◽

10.1345/aph.1a315 ◽

2002 ◽

Vol 36 (6) ◽

pp. 975-980 ◽

Cited By ~ 1

Author(s):

Karl J Madaras-Kelly ◽

Stephanie B Magdanz ◽

Christopher K Johnson ◽

Sandra G Jue

Keyword(s):

Chronic Bronchitis ◽

Term Treatment ◽

Cure Rate ◽

Term Outcome ◽

Long Term Treatment ◽

Acute Exacerbations ◽

Short And Long Term ◽

Traditional Therapies ◽

Cure Rates

OBJECTIVE: To determine whether the cure rate was similar between traditional and newer antibiotics in the treatment of acute exacerbations of chronic bronchitis (AECB), to determine whether antibiotic selection during the first AECB of the season influences the frequency of subsequent AECB, and to identify variables associated with poor short- and long-term treatment outcome. METHODS: A retrospective analysis of subjects seen for management of their first seasonal AECB was conducted. Subjects were stratified into traditional therapies (n = 95) or newer therapies (n = 101) by antibiotic prescription. RESULTS: There was no difference in initial cure rates between older versus newer antibiotics (93% vs. 95%; p = 0.48). There was no difference in the number of subjects that remained AECB-free for 6 months after initial treatment with older versus newer antibiotic regimens (34% vs. 28%; p = 0.37). Oxygen initiation or increased dose (OR 10.9; 95% CI 1.4 to 84.2; p = 0.02) was the only variable independently associated with lack of AECB resolution. Nonsmoking status trended toward an association with remaining AECB-free at 180 days (OR 0.39; 95% CI 0.15 to 1.01; p = 0.053). CONCLUSIONS: The use of older versus newer antibiotics did not independently predict short-term outcome or future AECB.

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Faktor Yang Berhubungan Dengan Kepatuhan Minum Obat Pasien TB Di Wilayah Kerja Puskesmas Parongpong

Jurnal Keperawatan Muhammadiyah ◽

10.30651/jkm.v5i1.4536 ◽

2020 ◽

Vol 5 (1) ◽

Author(s):

Imanuel Sri Mei Wulandari ◽

Jeanny Rantung ◽

Evelin Malinti

Keyword(s):

Medication Adherence ◽

Significant Relationship ◽

Quantitative Research ◽

Community Health Center ◽

Term Treatment ◽

Dominant Factor ◽

Cure Rate ◽

Tb Treatment ◽

Long Term Treatment

Background: Everyone has a risk of contracting tuberculosis, this disease also develops rapidly in areas that have high humidity. Mycobacterium is infecting through droplets released by the patient. TB treatment is a long-term treatment which medication is consumed every day, to achieve success in treatment requires adherence from patients to consume drugs.Objective: this research is to find out the factors that influence medication adherence of TB patients in Parongpong Health CenterMethod: Methodology of The study used is a quantitative research design with a correlation approach involving 23 respondents who are undergoing treatment at the Parongpong Community Health Center, respondents selected using purposive sampling. The instrument in this study was a questionnaire that was analyzed using the Spearman rho.Result: From the results of data analysis, it was found that gender had a significant relationship with medication adherence. The four factors studied have a significant relationship to medication adherence with p values <0.05, closeness of knowledge relations (0.620), self-stigma (0.467), self-efficacy (0.494), and family support (0.482)).Conclution: Respondents' knowledge is the most dominant factor in influencing medication adherence. Researcher given advice is to maintain adherence to take medication until the completion of the treatment program, to increase the cure rate of TB patients

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Long-Term Treatment of HIV-Infected MT-4 Cells in Culture with HIV Proteinase Inhibitor RO 31-8959 Leads to Complete Cure of Infection

Antiviral Chemistry and Chemotherapy ◽

10.1177/095632029400500405 ◽

1994 ◽

Vol 5 (4) ◽

pp. 236-242 ◽

Cited By ~ 4

Author(s):

H. Nitschko ◽

H. Lindhofer ◽

H. Schätzl ◽

J. Eberle ◽

G. Deby ◽

...

Keyword(s):

Cell Culture ◽

Cell Death ◽

Hiv Infection ◽

Proteinase Inhibitor ◽

Proteinase Inhibitors ◽

Antiviral Effect ◽

Term Treatment ◽

Long Term Treatment ◽

Drug Removal

An HIV-infected cell culture was treated with the specific HIV proteinase inhibitor Ro 31-8959 for three months to analyse the antiviral effect and possible cytotoxicity of the drug in long-term treatment. The drug was added 1 h after HIV infection with 0.002 m.o.i. and maintained for 87 days in the cell culture. There was no detectable cell death nor any evidence of HIV production in this time. Cells were proven to be initially infected, since premature drug removal led to a re-emergence of infectious HIV and cell death. However, after 87 days of treatment the drug could be removed safely and HIV was cleared demonstrably from the culture. These data suggest that long-term dosage may be advantageous to the clinical treatment of HIV infection by HIV proteinase inhibitors.

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