VEGF-Mediated Effects on Brain Microvascular Endothelial Tight Junctions and Transmigration of Breast Cancer Cells Across the Blood-Brain Barrier

2013 ◽  
pp. 247-261 ◽  
Author(s):  
Shalom Avraham ◽  
Shuxian Jiang ◽  
Lili Wang ◽  
Yigong Fu ◽  
Hava Karsenty Avraham
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Tight Junctions ◽  
Blood Brain Barrier ◽  
Breast Cancer Cells ◽  
Brain Barrier ◽  
Mediated Effects ◽  
Blood Brain ◽  
Microvascular Endothelial

scholarly journals The proinflammatory peptide substance P promotes blood–brain barrier breaching by breast cancer cells through changes in microvascular endothelial cell tight junctions

2013 ◽  
Vol 134 (5) ◽  
pp. 1034-1044 ◽  
Author(s):  
Pedro L. Rodriguez ◽  
Shuxian Jiang ◽  
Yigong Fu ◽  
Shalom Avraham ◽  
Hava Karsenty Avraham
Keyword(s):  
Breast Cancer ◽  
Endothelial Cell ◽  
Substance P ◽  
Cancer Cells ◽  
Tight Junctions ◽  
Blood Brain Barrier ◽  
Breast Cancer Cells ◽  
Brain Barrier ◽  
Microvascular Endothelial Cell ◽  
Blood Brain

Angiopoietin-2 mediates blood-brain barrier impairment and colonization of triple-negative breast cancer cells in brain

2014 ◽  
Vol 232 (3) ◽  
pp. 369-381 ◽  
Author(s):  
Hava Karsenty Avraham ◽  
Shuxian Jiang ◽  
Yigong Fu ◽  
Harikrishna Nakshatri ◽  
Haim Ovadia ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Blood Brain Barrier ◽  
Triple Negative Breast Cancer ◽  
Breast Cancer Cells ◽  
Triple Negative ◽  
Brain Barrier ◽  
Blood Brain ◽  
Angiopoietin 2

scholarly journals ST6GALNAC5 Expression Decreases the Interactions between Breast Cancer Cells and the Human Blood-Brain Barrier

2016 ◽  
Vol 17 (8) ◽  
pp. 1309 ◽  
Author(s):  
Aurore Drolez ◽  
Elodie Vandenhaute ◽  
Clément Delannoy ◽  
Justine Dewald ◽  
Fabien Gosselet ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Blood Brain Barrier ◽  
Human Blood ◽  
Breast Cancer Cells ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals SNORA71B promotes breast cancer cells across blood–brain barrier by inducing epithelial-mesenchymal transition

Breast Cancer ◽  
2020 ◽  
Vol 27 (6) ◽  
pp. 1072-1081
Author(s):  
Sijia Duan ◽  
Xuliang Luo ◽  
Huihui Zeng ◽  
Xiang Zhan ◽  
Chunlei Yuan
Keyword(s):  
Breast Cancer ◽  
Brain Metastasis ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Blood Brain Barrier ◽  
Epithelial Mesenchymal Transition ◽  
Brain Barrier ◽  
Breast Cancer Patients ◽  
Mesenchymal Transition ◽  
Blood Brain

Abstract Background Brain metastasis (BM) is a dreadful complication that significantly impacts the quality of life in breast cancer patients. A key process during brain metastasis is the migration of cancer cells across blood–brain barrier (BBB). However, the role of snoRNAs regulating BBB in BM is still unknown. Methods Here SNORic and GEO databases were used to identify differentially expressed snoRNAs between brain metastatic and non-metastatic breast cancer (BC) tissues. The effects of SNORA71B on the capacities of proliferation, migration, invasion, epithelial-mesenchymal transition (EMT), and BBB invasion of BC cells were evaluated by CCK8, transwell, western blot, and BBB model, respectively. Results SNORA71B was highly expressed in high BM BC tissues and cells compared to low BM BC controls. Survival analysis revealed high expression of SNORA71B was significantly associated with poor PPS and OS in breast cancer patients. ROC curve showed that SNORA71B might act as biomarker for breast cancer. Moreover, SNORA71B significantly promoted proliferation, migration, and invasion of BC cells with different BM abilities. Importantly, SNORA71B promoted the EMT process of low BM BC cells. SNORA71B knockdown inhibited the high BM BC cells across BBB, while EMT activator dramatically abrogated this inhibited effect. Conclusions In conclusion, SNORA71B promotes BC cells across the BBB partly via inducing EMT.

scholarly journals GPR55-mediated effects on brain microvascular endothelial cells and the blood–brain barrier

Neuroscience ◽  
2019 ◽  
Vol 414 ◽  
pp. 88-98 ◽  
Author(s):  
Luciana M. Leo ◽  
Boluwatife Familusi ◽  
Michelle Hoang ◽  
Raymond Smith ◽  
Kristen Lindenau ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Microvascular Endothelial Cells ◽  
Brain Microvascular Endothelial Cells ◽  
Mediated Effects ◽  
Blood Brain ◽  
Microvascular Endothelial

The treatment of brain metastasis from breast cancer, role of blood-brain barrier disruption and early experience with trastuzumab

Therapy ◽  
2006 ◽  
Vol 3 (1) ◽  
pp. 97-112 ◽  
Author(s):  
Rose Marie Tyson ◽  
Dale F Kraemer ◽  
Matthew A Hunt ◽  
Leslie L Muldoon ◽  
Peter Orbay ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Brain Metastasis ◽  
Blood Brain Barrier ◽  
Early Experience ◽  
Brain Barrier ◽  
Barrier Disruption ◽  
Blood Brain Barrier Disruption ◽  
Blood Brain ◽  
Brain Barrier Disruption

scholarly journals Bisphenol A Inhibits the Transporter Function of the Blood-Brain Barrier by Directly Interacting with the ABC Transporter Breast Cancer Resistance Protein (BCRP)

2021 ◽  
Vol 22 (11) ◽  
pp. 5534
Author(s):  
Elin Engdahl ◽  
Maarten van Schijndel ◽  
Dimitrios Voulgaris ◽  
Michela Di Criscio ◽  
Kerry Ramsbottom ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Bisphenol A ◽  
Blood Brain Barrier ◽  
Breast Cancer Resistance Protein ◽  
Brain Barrier ◽  
Production Volume ◽  
Cancer Resistance ◽  
Blood Brain ◽  
Resistance Protein

The breast cancer resistance protein (BCRP) is an important efflux transporter in the blood-brain barrier (BBB), protecting the brain from a wide range of substances. In this study, we investigated if BCRP function is affected by bisphenol A (BPA), a high production volume chemical used in common consumer products, as well as by bisphenol F (BPF) and bisphenol S (BPS), which are used to substitute BPA. We employed a transwell-based in vitro cell model of iPSC-derived brain microvascular endothelial cells, where BCRP function was assessed by measuring the intracellular accumulation of its substrate Hoechst 33342. Additionally, we used in silico modelling to predict if the bisphenols could directly interact with BCRP. Our results showed that BPA significantly inhibits the transport function of BCRP. Additionally, BPA was predicted to bind to the cavity that is targeted by known BCRP inhibitors. Taken together, our findings demonstrate that BPA inhibits BCRP function in vitro, probably by direct interaction with the transporter. This effect might contribute to BPA’s known impact on neurodevelopment.

scholarly journals TWEAK/Fn14 pathway modulates properties of a human microvascular endothelial cell model of blood brain barrier

2013 ◽  
Vol 10 (1) ◽  
Author(s):  
Delphine Stephan ◽  
Oualid Sbai ◽  
Jing Wen ◽  
Pierre-Olivier Couraud ◽  
Chaim Putterman ◽  
...  
Keyword(s):  
Endothelial Cell ◽  
Blood Brain Barrier ◽  
Cell Model ◽  
Brain Barrier ◽  
Microvascular Endothelial Cell ◽  
Human Microvascular Endothelial Cell ◽  
Blood Brain ◽  
Microvascular Endothelial

scholarly journals The role of microvascular endothelial WNT signaling the formation of the blood brain barrier

SpringerPlus ◽  
2015 ◽  
Vol 4 (S1) ◽  
Author(s):  
Maria Grazia Lampugnani ◽  
Luca Bravi ◽  
Elisabetta Dejana
Keyword(s):  
Wnt Signaling ◽  
Blood Brain Barrier ◽  
Brain Barrier ◽  
Blood Brain ◽  
Microvascular Endothelial
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