Inborn errors of metabolism — consequences of long-term treatment for the individual, as derived from observations in phenylketonuria

SummaryIn 20 patients suffering from bleeding complications during long-term treatment with phenprocoumon, the depression of the activity of Factors II, VII, IX and X, on the average, was found to be stronger than in so-called adequately treated patients, whereas no statistically significant differences could be demonstrated between the average activity of the 4 factors. The individual variations between the 4 factors were higher than those found in normal individuals and adequately treated patients.Thrombotest activity appeared to be considerably lower than the average factor activity. This discrepancy is mainly caused by the action of the recently discovered circulating anticoagulant occurring in coumarin-treated or vitamin K-deficient patients.

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Effect of Long-Term Treatment on Personality Change of High-Risk Alcoholics

Psychological Reports ◽

10.2466/pr0.1972.31.3.799 ◽

1972 ◽

Vol 31 (3) ◽

pp. 799-802 ◽

Cited By ~ 6

Author(s):

Paul C. Nelson ◽

Helmut Hoffmann

Keyword(s):

High Risk ◽

Term Treatment ◽

Personality Change ◽

Special Treatment ◽

Social Stability ◽

Recidivism Rate ◽

Clinical Scales ◽

Long Term Treatment ◽

The Individual

The Differential Personality Inventory was administered 6 wk. after admission to 40 male high-risk alcoholics. Participants in a long-term special treatment program were characterized by a high recidivism rate. Retests were obtained 16 wk. later and Ss scored significantly lower on 5 of the 27 clinical scales. The reliability coefficient of the individual scales ranged from 0.57 to 0.92. Data show that high-risk alcoholics change relatively little over a 16-wk. period. It was suggested that certain alcoholics needed long-term treatment because they repeatedly failed to respond to treatment and were unable to control their drinking. It was also hypothesized that repeated, uncontrolled drinking might be due to a lack of social stability.

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Long-Term Treatment of Patients with Recurrent Unipolar Major Depression: Evidence to Clinical Practice

CNS Spectrums ◽

10.1017/s1092852900015194 ◽

2006 ◽

Vol 11 (S15) ◽

pp. 4-5 ◽

Cited By ~ 2

Author(s):

Martin B. Keller

Keyword(s):

Treatment Strategies ◽

Patient Characteristics ◽

Evidence Base ◽

Term Treatment ◽

Recurrent Depression ◽

Long Term Treatment ◽

Risk Factors For Recurrence ◽

The Individual ◽

Term Management

Major depressive disorder (MDD) is almost exclusively recurrent. The vast majority of patients who experience one episode of MDD will eventually experience at least one more episode during their lifetime. The recurrent nature of MDD increases the burden to both the individual and society. Hence, it is imperative that treatment strategies focus on achieving remission acutely, as well as maintaining of remission and preventing recurrence. The articles in this supplement are based on presentations and a dialogue among a group of experts who convened for a roundtable discussion on improving long-term outcomes with antidepressant therapy.Improving long-term treatment of MDD begins with understanding the clinical course of recurrent depression and the ability to recognize those patients who are at greatest risk for recurrence. James H. Kocsis, MD, reviews the course of recurrent depression, emphasizing the tendency for it to progressively worsen. He also discusses patient characteristics and other risk factors for recurrence as well as current recommendations for long-term management of recurrent depression.Although long-term antidepressant maintenance treatment studies are somewhat limited in number, they provide the evidence base that shapes existing guidelines for long-term management of recurrent depression. Michael E. Thase, MD, examines this evidence for the different classes of antidepressants. In addition, Thase reviews evidence for the efficacy of psychotherapy and discusses its potentially important role in long-term depression management.

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The importance of psychological and nutritional follow-up after bariatric surgery: Literature review

Panorama brasileiro de tungstênio (w) entre os anos de 2008 e 2014 ◽

10.32749/nucleodoconhecimento.com.br/psychology/after-bariatric ◽

2021 ◽

pp. 20-44

Author(s):

Carla Viana Dendasck ◽

Rogério Bongestab dos Santos ◽

Vitor Maia Santos ◽

Tadeu Uggere de Andrade ◽

Adriano Ribeiro Meyer Pflug

Keyword(s):

Bariatric Surgery ◽

Literature Review ◽

Postoperative Period ◽

Term Treatment ◽

Psychological Status ◽

Postoperative Treatment ◽

Long Term Treatment ◽

The Individual

Obesity is a multifactorial chronic disease. The patient may present several clinical conditions associated with it. The clinical picture is complex, which can hinder the use of conventional treatments and methods. Bariatric surgery is an effective long-term treatment for this condition. Based on a literature review, the article aims to discuss the importance of post-bariatric psychological and nutritional follow-up. The fundamental question that underpits this study is: how can typical strategies in the postoperative period contribute to the individual undergoing surgery to give greater importance to his diet and mental health? The most effective treatment strategy has been bariatric surgery, however, the multidisciplinary evaluation that scores the patient’s biological, social and psychological status is fundamental, since psychopathological changes are common to obese individuals. Although bariatric surgery contributes to the improvement in the quality of life of patients, there needs to be greater attention to postoperative treatment. These individuals should be encouraged to continue with nutritional and psychological follow-up in the postoperative period, so that it is possible to prevent possible complications in the medium and long term.

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Inferring immunological control mechanisms from TKI dose alterations in CML patients

10.1101/722546 ◽

2019 ◽

Author(s):

Tom Hähnel ◽

Christoph Baldow ◽

Artur C. Fassoni ◽

Joëlle Guilhot ◽

François Guilhot ◽

...

Keyword(s):

Immune Response ◽

Kinase Inhibitors ◽

Clinical Findings ◽

Term Treatment ◽

Control Mechanisms ◽

Treatment Cessation ◽

Long Term Treatment ◽

Time Courses ◽

The Individual

AbstractRecent clinical findings in chronic myeloid leukemia (CML) patients suggest that the risk of molecular recurrence after stopping tyrosine kinase inhibitors (TKI) treatment substantially depend on an individual, leukemia-specific immune response. However, it is still not possible to prospectively identify patients that will most likely remain in a long-term treatment free remission (TFR). Here, we use a mathematical model for CML, which explicitly includes an anti-leukemic (presumably immunological) effect and apply it to a set of patients (n=60) for whom BCR-ABL/ABL time courses had been quantified before and after TKI stop. We demonstrate that such a feedback control is conceptually necessary to explain long-term remission as observed in about half of the patients. Based on simulation results we classify the patient data sets into three different groups according to their predicted immune system configuration. While one class of patients requires a complete CML eradication to achieve TFR, other patients are able to control the leukemia after treatment cessation. Among them, we identified a third class of patients, which only maintains TFR if an optimal balance between leukemia abundance and immunological activation is achieved before treatment cessation. Further, we demonstrate that the immune response classification of the patients cannot be obtained solely from BCR-ABL measurements before treatment cessation. However, our results strongly suggest that changes in the BCR-ABL dynamics arising after system perturbations, such as TKI dose reduction, holds the information to predict the individual outcome after treatment cessation.

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Long-Term Treatment of Inborn Errors of Urea Synthesis

Advances in Hepatic Encephalopathy and Urea Cycle Diseases ◽

10.1159/000410808 ◽

2015 ◽

pp. 187-195

Author(s):

M. L. Batshaw

Keyword(s):

Term Treatment ◽

Urea Synthesis ◽

Inborn Errors ◽

Long Term Treatment

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Idiopathic venous thrombosis

Hämostaseologie ◽

10.1055/s-0037-1616876 ◽

2006 ◽

Vol 26 (01) ◽

pp. 48-51 ◽

Cited By ~ 1

Author(s):

S. Haas

Keyword(s):

Venous Thromboembolism ◽

Vitamin K ◽

Vitamin K Antagonists ◽

Term Treatment ◽

Bleeding Complications ◽

Individual Risk ◽

Long Term Treatment ◽

Net Clinical Benefit ◽

The Individual

SummaryIdiopathic venous thromboembolism has been shown to be associated with a high frequency of recurrence. Therefore, the most important aim of long-term treatment is secondary prevention. It has also been shown that long-term anticoagulation with vitamin K antagonists can impressively reduce the rate of recurrence. However, this effect was only maintained during anticoagulation and disappeared after cessation of anticoagulant therapy. Unfortunately, the individual risk of recurrence is not predictable. Therefore, longterm anticoagulation appears beneficial across all subgroups of patients suffering from venous thromboembolism, regardless of the presence of thrombophilia or other burden of the disease. Despite the increasing body of evidence regarding the advantages of long-term anticoagulation, bleeding complications may limit the net clinical benefit of this strategy. Thus, the development of anticoagulants having a low potential for adverse reactions and providing similar beneficial antithrombotic effects to vitamin K antagonists will enhance the readiness for their wide spread use and life long administration.

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Orthodontics and Prosthodontics—A Common Basis for Diagnosis, Treatment Planning and Research

British Journal of Orthodontics ◽

10.1179/bjo.2.2.113 ◽

1975 ◽

Vol 2 (2) ◽

pp. 113-117 ◽

Cited By ~ 1

Author(s):

P. R. L'Estrange

Keyword(s):

Treatment Planning ◽

Term Treatment ◽

Joint Research ◽

Considerable Difficulty ◽

Common Basis ◽

Long Term Treatment ◽

The Common ◽

The Individual ◽

Made In

With a dentate patient parameters are clearly defined. In the absence of pre-extraction data the prosthetic restoration of an edentulous patient can present considerable difficulty. Failure on the part of the individual to adapt to prosthetic treatment may in many instances be attributable to errors in diagnosis and treatment planning. An appreciation of the range of variation of hard and soft-tissue morphology in the population is a necessary Pre-requisite to successful long-term treatment. An attempt is made in this paper to show the common basis which exists between orthodontics and prosthetic dentistry in aspects of diagnosis. The application of concepts Well established in orthodontics to prosthetic treatment is discussed in addition to possible avenues of joint research between the two specialities of dentistry.

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