scholarly journals The Role of Tumor Suppressor p53 in the Antioxidant Defense and Metabolism

2014 ◽  
pp. 337-358 ◽  
Author(s):  
Andrei V. Budanov
Keyword(s):  
Tumor Suppressor ◽  
Antioxidant Defense ◽  
Tumor Suppressor P53

scholarly journals The role of the tumor suppressor p53 in spermatogenesis

1998 ◽  
Vol 5 (8) ◽  
pp. 669-677 ◽  
Author(s):  
Tim L Beumer ◽  
Hermien L Roepers-Gajadien ◽  
Iris S Gademan ◽  
Paul PW van Buul ◽  
Gabriel Gil-Gomez ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Suppressor P53

scholarly journals A Different Facet of p53 Function: Regulation of Immunity and Inflammation During Tumor Development

2021 ◽  
Vol 9 ◽  
Author(s):  
Di Shi ◽  
Peng Jiang
Keyword(s):  
Tumor Suppressor ◽  
Immune Responses ◽  
Tumor Development ◽  
Suppressive Effect ◽  
Innate Immune ◽  
Tumor Suppressor P53 ◽  
Cycle Arrest ◽  
Evolutionarily Conserved ◽  
Cellular Stresses

As a key transcription factor, the evolutionarily conserved tumor suppressor p53 (encoded by TP53) plays a central role in response to various cellular stresses. A variety of biological processes are regulated by p53 such as cell cycle arrest, apoptosis, senescence and metabolism. Besides these well-known roles of p53, accumulating evidence show that p53 also regulates innate immune and adaptive immune responses. p53 influences the innate immune system by secreted factors that modulate macrophage function to suppress tumourigenesis. Dysfunction of p53 in cancer affects the activity and recruitment of T and myeloid cells, resulting in immune evasion. p53 can also activate key regulators in immune signaling pathways which support or impede tumor development. Hence, it seems that the tumor suppressor p53 exerts its tumor suppressive effect to a considerable extent by modulating the immune response. In this review, we concisely discuss the emerging connections between p53 and immune responses, and their impact on tumor progression. Understanding the role of p53 in regulation of immunity will help to developing more effective anti-tumor immunotherapies for patients with TP53 mutation or depletion.

Abstract A28: Understanding the role of the tumor suppressor p53 in pancreatic cancer development

2018 ◽  
Author(s):  
Brittany M. Flowers ◽  
Patty B. Garcia ◽  
Barbara M. Grüner ◽  
Monte M. Winslow ◽  
Laura D. Attardi
Keyword(s):  
Pancreatic Cancer ◽  
Tumor Suppressor ◽  
Cancer Development ◽  
Tumor Suppressor P53

Inhibitory role of E2F-1 in the regulation of tumor suppressor p53 during DNA damage response

2012 ◽  
Vol 421 (1) ◽  
pp. 57-63 ◽  
Author(s):  
Yukari Yoshihara ◽  
Dan Wu ◽  
Natsumi Kubo ◽  
Meixiang Sang ◽  
Akira Nakagawara ◽  
...  
Keyword(s):  
Dna Damage ◽  
Tumor Suppressor ◽  
Dna Damage Response ◽  
Tumor Suppressor P53 ◽  
Inhibitory Role ◽  
Damage Response

scholarly journals BAG2 promotes tumorigenesis through enhancing mutant p53 protein levels and function

eLife ◽  
2015 ◽  
Vol 4 ◽  
Author(s):  
Xuetian Yue ◽  
Yuhan Zhao ◽  
Juan Liu ◽  
Cen Zhang ◽  
Haiyang Yu ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Tumor Growth ◽  
Poor Prognosis ◽  
P53 Protein ◽  
Underlying Mechanism ◽  
Mutant P53 ◽  
Tumor Suppressor P53 ◽  
Protein Levels ◽  
And Function

Tumor suppressor p53 is the most frequently mutated gene in tumors. Many mutant p53 (mutp53) proteins promote tumorigenesis through the gain-of-function (GOF) mechanism. Mutp53 proteins often accumulate to high levels in tumors, which is critical for mutp53 GOF. Its underlying mechanism is poorly understood. Here, we found that BAG2, a protein of Bcl-2 associated athanogene (BAG) family, promotes mutp53 accumulation and GOF in tumors. Mechanistically, BAG2 binds to mutp53 and translocates to the nucleus to inhibit the MDM2-mutp53 interaction, and MDM2-mediated ubiquitination and degradation of mutp53. Thus, BAG2 promotes mutp53 accumulation and GOF in tumor growth, metastasis and chemoresistance. BAG2 is frequently overexpressed in tumors. BAG2 overexpression is associated with poor prognosis in patients and mutp53 accumulation in tumors. These findings revealed a novel and important mechanism for mutp53 accumulation and GOF in tumors, and also uncovered an important role of BAG2 in tumorigenesis through promoting mutp53 accumulation and GOF.

scholarly journals The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses

2021 ◽  
Vol 9 ◽  
Author(s):  
Danrui Cui ◽  
Ruirui Qu ◽  
Dian Liu ◽  
Xiufang Xiong ◽  
Tingbo Liang ◽  
...  
Keyword(s):  
Tumor Suppressor ◽  
Current Knowledge ◽  
Human Cancer ◽  
Mammalian Target Of Rapamycin ◽  
Mtor Pathway ◽  
Tumor Suppressor P53 ◽  
Induce Cell Cycle Arrest ◽  
Downstream Effectors ◽  
Cellular Stresses

The tumor suppressor p53 is activated upon multiple cellular stresses, including DNA damage, oncogene activation, ribosomal stress, and hypoxia, to induce cell cycle arrest, apoptosis, and senescence. Mammalian target of rapamycin (mTOR), an evolutionarily conserved serine/threonine protein kinase, serves as a central regulator of cell growth, proliferation, and survival by coordinating nutrients, energy, growth factors, and oxygen levels. p53 dysfunction and mTOR pathway hyperactivation are hallmarks of human cancer. The balance between response to stresses or commitment to cell proliferation and survival is governed by various regulatory loops between the p53 and mTOR pathways. In this review, we first briefly introduce the tumor suppressor p53 and then describe the upstream regulators and downstream effectors of the mTOR pathway. Next, we discuss the role of p53 in regulating the mTOR pathway through its transcriptional and non-transcriptional effects. We further describe the complicated role of the mTOR pathway in modulating p53 activity. Finally, we discuss the current knowledge and future perspectives on the coordinated regulation of the p53 and mTOR pathways.

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