Differences in the Electrical Impedance Spectroscopy Variables Between Right and Left Forearms in Healthy People: A Non Invasive Method to Easy Monitoring Structural Changes in Human Limbs?

2020 ◽  
pp. 216-220
Author(s):  
A. H. Dell’Osa ◽  
A. Concu ◽  
M. Gel ◽  
A. Fois ◽  
Q. Mela ◽  
...  
Keyword(s):  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Structural Changes ◽  
Electrical Impedance Spectroscopy ◽  
Healthy People ◽  
Non Invasive ◽  
Invasive Method

scholarly journals Prognostic value of Electrical Impedance Spectroscopy (EIS) when used as an adjunct to Colposcopy – a longitudinal study

2020 ◽  
Vol 11 (1) ◽  
pp. 81-86
Author(s):  
B. H. Brown ◽  
P.E. Highfield ◽  
J. A. Tidy
Keyword(s):  
Impedance Spectroscopy ◽  
Cell Size ◽  
Electrical Impedance ◽  
Structural Changes ◽  
Extracellular Volume ◽  
Electrical Impedance Spectroscopy ◽  
Low Grade ◽  
Prognostic Information ◽  
Size Diversity ◽  
Eis Measurements

AbstractObjectiveColposcopy can be used with Electrical Impedance Spectroscopy (EIS) as an adjunct, to assess the presence of High Grade Cervical Intra-epithelial Neoplasia (CIN2+). This analysis of longitudinal data has used the results from women with a negative colposcopy, in order to see if the initial (index) EIS results were able to predict the women who subsequently developed CIN2+. A further objective was to investigate what tissue structural changes might be reflected in the electrical impedance spectra.Methods847 patients were referred with low grade cytologly. EIS measurements were made around the transformation zone of the cervix during colposcopy. Every EIS spectrum was matched to a template representing CIN2+ and the result was positive if the match exceeded a probability index threshold. The colposcopic impression was also recorded. All the women who developed biopsy proven CIN2+ within three years of the index colposcopy were identified.ResultsThe median follow-up was 30.5 months. Where both CI and EIS were initially positive, there was an increased prevalence (8.13%) of CIN2+ developing as opposed to 3.45% in the remaining patients (p=0.0159). In addition, if three or more EIS spectra were positive there was a higher prevalence (9.62% as opposed to 3.56% p=0.0132) of CIN2+ at three years. The index spectra recorded from the women who developed CIN2+ showed EIS changes consistent with increases in the extracellular volume and in cell size inhomogeneity.ConclusionEIS does offer prognostic information on the risk of CIN2+ developing over the three-year period following the EIS measurements. The changes in EIS spectra are consistent with an increase in cell size diversity as pre-malignancy develops. These changes may be a consequence of increased genetic diversity as neoplasia develops.

scholarly journals Electrical Impedance Spectroscopy to easily assess structural changes in dominant versus auxiliary upper arms due to pathophysiological events

2019 ◽  
Author(s):  
A. H. Dell’Osa ◽  
A. Fois ◽  
Q. Mela ◽  
A. Loviselli ◽  
A. Capone ◽  
...  
Keyword(s):  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Structural Changes ◽  
Electrical Impedance Spectroscopy ◽  
Water Volume ◽  
Surface Electrodes ◽  
Clinical Assessments ◽  
Electronic Board ◽  
Healthy Female ◽  
Resistive Component

AbstractThe resistive component of the bioimpedance was non invasively assessed in both right and left forearms of 11 healthy female and 9 males (28.4 ± 1.4 years; 63.8 ± 11.8 kg; 167.4 ± 7.5 cm) all of which were right-handed. A homemade electrical impedance spectroscopy device which implemented the AD 5933 electronic board from Analog Devices Inc., USA, was utilized, and the bipolar modality of bioimpedance assessment was chosen using two disposable ECG surface electrodes placed in each end of the biceps brachial muscles while subject were comfortably sitting. Forearms resistance was acquired at sweeping frequencies steps of 15, 30, 45, 60 and 75 KHz. Results showed a significantly lower man value of resistance in right versus left forearms (- 27.4 Ω, P<0.05), or about -4%, at the frequency of 15 KHz. Even though there was a progressive reduction, this right versus left forearm resistance difference persisted as statistically significant up to the frequency of 45 KHz. It was concluded that the risk of some mistakes do exists when lymphedema may occur in one arm and electrical impedance spectroscopy was utilized to monitoring in that arm the water volume trend in comparison with the other side arm since these results underline in the main forearm a largely low value of the resistance than in the auxiliary one, even in healthy subjects. So, care must be taken when the electrical impedance spectroscopy was adopted in these clinical assessments.

Non-invasive assessment of radiation injury with electrical impedance spectroscopy

2004 ◽  
Vol 49 (5) ◽  
pp. 665-683 ◽  
Author(s):  
K Sunshine Osterman ◽  
P Jack Hoopes ◽  
Christine DeLorenzo ◽  
David J Gladstone ◽  
Keith D Paulsen
Keyword(s):  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Radiation Injury ◽  
Electrical Impedance Spectroscopy ◽  
Non Invasive

scholarly journals Bone Fracture Detection by Electrical Bioimpedance: First Non-Invasive Measurements in Ex-Vivo Mammalian Femur

2019 ◽  
Author(s):  
A. H. Dell’Osa ◽  
A. Concu ◽  
F. R. Dobarro ◽  
J. C. Felice
Keyword(s):  
Impedance Spectroscopy ◽  
Electrical Impedance ◽  
Bone Fractures ◽  
Ex Vivo ◽  
Fracture Site ◽  
Electrical Impedance Spectroscopy ◽  
X Rays ◽  
Fracture Detection ◽  
Real Component ◽  
Non Invasive

AbstractThe fracture of long bones is one of the pathologies of greater demand of systems of medical emergencies, the method used for the diagnosis, the radiology of X-rays, produces damages to the patients and to the hospitals environment. For these reasons, our group is studying the implementation of a new diagnostic technique for the detection of bone fractures by bioimpedance measurements. To simulate a limb, two phantom of bovine femurs (the one with an entire bone and the other with a sawn bone) were constructed and non-invasive Electrical Impedance Spectroscopy measurements were taken on them in order to identify differences in their respective Cole Cole diagrams. Impedance spectroscopy was performed by a frequency sweep between 1 Hz and 65 kHz at a fixed current of 1 mA. The results obtained show wide differences in the Cole Cole diagrams of both phantoms (entire and fractured bone), especially concerning the real component of the, which latter, around the bones section corresponding to that of the lesion in both femurs, was always lower in the fractured femur than the entire one. These first superficial (non-invasive) measurements correspond to the electrical impedance spectroscopy bases and these could -in turn- correspond to what occurs in mammals immediately after the fracture happens, i. e. a dramatic increase in electrical conductivity due to diffusion into the fracture site of more conductive materials such as the blood and the extravascular fluids.

scholarly journals Characterization and Monitoring of Titanium Bone Implants with Impedance Spectroscopy

Sensors ◽  
2020 ◽  
Vol 20 (16) ◽  
pp. 4358
Author(s):  
Alberto Olmo ◽  
Miguel Hernández ◽  
Ernesto Chicardi ◽  
Yadir Torres
Keyword(s):  
Impedance Spectroscopy ◽  
Pore Size ◽  
Bone Tissue ◽  
Electrical Impedance ◽  
Porous Titanium ◽  
Electrical Impedance Spectroscopy ◽  
Bone Implants ◽  
Non Invasive ◽  
Metallic Biomaterial ◽  
Porosity Percentage

Porous titanium is a metallic biomaterial with good properties for the clinical repair of cortical bone tissue, although the presence of pores can compromise its mechanical behavior and clinical use. It is therefore necessary to characterize the implant pore size and distribution in a suitable way. In this work, we explore the new use of electrical impedance spectroscopy for the characterization and monitoring of titanium bone implants. Electrical impedance spectroscopy has been used as a non-invasive route to characterize the volumetric porosity percentage (30%, 40%, 50% and 60%) and the range of pore size (100–200 and 355–500 mm) of porous titanium samples obtained with the space-holder technique. Impedance spectroscopy is proved to be an appropriate technique to characterize the level of porosity of the titanium samples and pore size, in an affordable and non-invasive way. The technique could also be used in smart implants to detect changes in the service life of the material, such as the appearance of fractures, the adhesion of osteoblasts and bacteria, or the formation of bone tissue.

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