Enhancing Osteochondral Tissue Regeneration of Gellan Gum by Incorporating Gallus gallus var Domesticus-Derived Demineralized Bone Particle

2020 ◽  
pp. 79-93
Author(s):  
Muthukumar Thangavelu ◽  
David Kim ◽  
Young Woon Jeong ◽  
Wonchan Lee ◽  
Jun Jae Jung ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Gallus Gallus ◽  
Gellan Gum ◽  
Bone Particle ◽  
Osteochondral Tissue ◽  
Demineralized Bone

Characterization and Potential of a Bilayered Hydrogel of Gellan Gum and Demineralized Bone Particles for Osteochondral Tissue Engineering

2020 ◽  
Vol 12 (31) ◽  
pp. 34703-34715
Author(s):  
Joo Hee Choi ◽  
Namyoung Kim ◽  
Min A. Rim ◽  
Wonchan Lee ◽  
Jeong Eun Song ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Gellan Gum ◽  
Osteochondral Tissue ◽  
Bone Particles ◽  
Osteochondral Tissue Engineering ◽  
Demineralized Bone

scholarly journals Injectable gellan-gum/hydroxyapatite-based bilayered hydrogel composites for osteochondral tissue regeneration

2018 ◽  
Vol 12 ◽  
pp. 309-321 ◽  
Author(s):  
D.R. Pereira ◽  
R.F. Canadas ◽  
J. Silva-Correia ◽  
A. da Silva Morais ◽  
M.B. Oliveira ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Gellan Gum ◽  
Hydrogel Composites ◽  
Osteochondral Tissue

Fabrication of nanocomposite/nanofibrous functionally graded biomimetic scaffolds for osteochondral tissue regeneration

2021 ◽  
Author(s):  
Fatemeh Hejazi ◽  
Shadab Bagheri‐Khoulenjani ◽  
Nafiseh Olov ◽  
Darya Zeini ◽  
Atefeh Solouk ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Functionally Graded ◽  
Biomimetic Scaffolds ◽  
Osteochondral Tissue

scholarly journals Cell-Free Demineralized Bone Matrix for Mesenchymal Stem Cells Survival and Colonization

Materials ◽  
2019 ◽  
Vol 12 (9) ◽  
pp. 1360 ◽  
Author(s):  
Monica Mattioli-Belmonte ◽  
Francesca Montemurro ◽  
Caterina Licini ◽  
Iolanda Iezzi ◽  
Manuela Dicarlo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tissue Regeneration ◽  
Demineralized Bone Matrix ◽  
Bone Matrix ◽  
Morphological Observation ◽  
Type I ◽  
Demineralized Bone

Decellularized bone matrix is receiving much attention as biological scaffolds and implantable biomaterials for bone tissue regeneration. Here, we evaluated the efficacy of a cell-free demineralized bone matrix on mesenchymal stem cells (MSCs) survival and differentiation in vitro. The seeding of human umbilical cord-derived MSCs (hUC-SCs) on decellularized bone matrices up to 14 days was exploited, assessing their capability of scaffold colonization and evaluating gene expression of bone markers. Light and Scanning Electron Microscopies were used. The obtained cell-free decalcified structures showed elastic moduli attributable to both topology and biochemical composition. Morphological observation evidenced an almost complete colonization of the scaffolds after 14 days of culture. Moreover, in hUC-SCs cultured on decalcified scaffolds, without the addition of any osteoinductive media, there was an upregulation of Collagen Type I (COL1) and osteonectin (ON) gene expression, especially on day 14. Modifications in the expression of genes engaged in stemness were also detected. In conclusion, the proposed decellularized bone matrix can induce the in vitro hUC-SCs differentiation and has the potential to be tested for in in vivo tissue regeneration.

scholarly journals A Rabbit Femoral Condyle Defect Model for Assessment of Osteochondral Tissue Regeneration

2020 ◽  
Vol 26 (11) ◽  
pp. 554-564
Author(s):  
Jason L. Guo ◽  
Yu Seon Kim ◽  
Elysse A. Orchard ◽  
Jeroen J.J.P. van den Beucken ◽  
John A. Jansen ◽  
...  
Keyword(s):  
Tissue Regeneration ◽  
Femoral Condyle ◽  
Defect Model ◽  
Osteochondral Tissue
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