Squamous cell carcinoma characterized by poor prognosis due to aggressive tumor growth and dissemination high rate of
tumor cell . age ranged of patient case included in the study 40-62 years and mean age 55±99. The sex distribution
male/female ratio 1:1. Male case 15 and female 15 of the present study The results of clinical forums showed in the current
study was endophytic 10(33.3%) in the same time Exophytic were presented in 20 cases (76.7%). Regarding distribution
of the tumors site, the preponderance of them 19 cases 73.3% were located alveolar mucosa, followed by in the tongue 11
cases(36.7%) Tumor stage was analyzed and recorded in Oral squamous cell carcinoma included cases, the preponderance
of them were Stage II 11 cases 36.7% followed by stage III 10 cases 33.3% , 9 cases 30.0% were stage I. While Concerning
tumor grade, majority of them 15 cases 50% had grade II moderately differentiated SCC, while 11 cases 36.7% had grade
III poorly differentiated SCC and 4 cases 13.3% had grade I well differentiated SCC Positive TGF-β3 immunostaining was
detected as cell with staining brown color, all tissues sections included show Positive expression based on IHC teqnique.
Positive Transforming Growth Factor TGF-β3 Immuno staining was found in all case results and display that 4 samples
with percentage 13.3% expressed strong positive 87.67 ± 1.45 expression , 11cases 36.7% showed 51.33 ±0.88 positive
expression moderate at the same time 15 samples 50.0% showed positive weak expression.
