Magnitude and Characteristics of Children with Congenital Disabilities in India

2021 ◽  
pp. 195-207
Author(s):  
Amruta Chutke
Keyword(s):  
Congenital Disabilities

scholarly journals A Label and Probe-Free Zika Virus Immunosensor Prussian Blue@carbon Nanotube-Based for Amperometric Detection of the NS2B Protein

Biosensors ◽  
2021 ◽  
Vol 11 (5) ◽  
pp. 157
Author(s):  
Bárbara V. M. Silva ◽  
Marli T. Cordeiro ◽  
Marco A. B. Rodrigues ◽  
Ernesto T. A. Marques ◽  
Rosa F. Dutra
Keyword(s):  
Carbon Nanotube ◽  
Prussian Blue ◽  
Zika Virus ◽  
Point Of Care ◽  
Amperometric Detection ◽  
Cross Reactivity ◽  
Structural Protein ◽  
Serum Samples ◽  
Polypyrrole Composite ◽  
Congenital Disabilities

Zika virus (ZIKV) is a mosquito-borne infection, predominant in tropical and subtropical regions causing international concern due to the ZIKV disease having been associated with congenital disabilities, especially microcephaly and other congenital abnormalities in the fetus and newborns. Development of strategies that minimize the devastating impact by monitoring and preventing ZIKV transmission through sexual intercourse, especially in pregnant women, since no vaccine is yet available for the prevention or treatment, is critically important. ZIKV infection is generally asymptomatic and cross-reactivity with dengue virus (DENV) is a global concern. An innovative screen-printed electrode (SPE) was developed for amperometric detection of the non-structural protein (NS2B) of ZIKV by exploring the intrinsic redox catalytic activity of Prussian blue (PB), incorporated into a carbon nanotube–polypyrrole composite. Thus, this immunosensor has the advantage of electrochemical detection without adding any redox-probe solution (probe-less detection), allowing a point-of-care diagnosis. It was responsive to serum samples of only ZIKV positive patients and non-responsive to negative ZIKV patients, even if the sample was DENV positive, indicating a possible differential diagnosis between them by NS2B. All samples used here were confirmed by CDC protocols, and immunosensor responses were also checked in the supernatant of C6/36 and in Vero cell cultures infected with ZIKV.

scholarly journals Health Risks Associated with the Consumption of Legumes Contaminated with Pesticides and Heavy Metals

2021 ◽  
Author(s):  
Motunrayo Ganiyat Akande
Keyword(s):  
Heavy Metals ◽  
Food Safety ◽  
Health Outcomes ◽  
Dietary Fiber ◽  
Health Effects ◽  
Health Risks ◽  
Scientific Literature ◽  
Human Beings ◽  
Safety Measures ◽  
Congenital Disabilities

Legumes have high nutritional value and they are important sources of protein, carbohydrates, fats and dietary fiber. The contamination of legumes with pesticides and heavy metals has been reported in scientific literature. Human beings are mainly exposed to the residues of pesticides and heavy metals through the dietary route. The purpose of this review chapter is to highlight the acute and chronic health risks that human beings may be exposed to as a result of the ingestion of legumes polluted with pesticides and heavy metals. Additionally, the mechanisms through which pesticides and heavy metals engender different undesirable health outcomes in human beings were stated. Scientific literature were perused and the information contained in them were collated to derive this chapter. Pesticides cause short-term health effects including hypersensitivity and mortality, while heavy metals induce acute effects like seizures and death. Some chronic untoward effects of pesticides are congenital disabilities and neurological damage. Heavy metals elicit disorders like anemia, hypertension and cancer. It is envisaged that the findings documented in this review will create awareness of the health risks posed by the contamination of legumes with the residues of pesticides and heavy metals so that food safety measures can be enforced globally.

Prevalence of Neural Tube Defects (NTDs) In And Around Varanasi Region: Some Observations

2021 ◽  
Author(s):  
Vaibhav Pandey ◽  
Surendra Kumar Pandey ◽  
Praveen Kumar Tiwari ◽  
Pragati Shakya ◽  
Shashank Shekhar Jha ◽  
...  
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Birth Defect ◽  
Neural Tube Closure ◽  
The World ◽  
Typical Type ◽  
Males And Females ◽  
One Year ◽  
Congenital Disabilities ◽  
Tube Closure

Abstract Congenital anomalies are one of the primary causes of infant mortality and disability in the world. Neural Tube Defects (NTDs) are the most typical type of birth defect resulting from the failure of Neural tube closure. In this retrospective hospital-based study, the data of the children affected byneural tube defects (NTDs) were analyzed. Prevalence of Hydrocephalous, Myelomeningocele (MMC), Encephalocele, Lipo MMC, Meningocele, Spina Bifida Occulta among children with more or less than one year of age and their occurrence in males and females was studied. The frequency of occurrence of cases of neural tube defects was significantly less among all the congenital disabilities, i.e., 5% of total cases studied. The prevalence of myelomeningocele, hydrocephalous, and Encephalocele was higher than other types of NTDs. This study concludes that the prevalence of hydrocephalous and myelomeningocele in this area raises a concern to have more research of their etiology.

Disability, Embodiment, and Slavery in the Old South

2021 ◽  
pp. 13-35
Author(s):  
Jenifer L. Barclay
Keyword(s):  
Historical Record ◽  
Future Generations ◽  
Old South ◽  
Economic Gain ◽  
Valuable Property ◽  
Shifting Boundaries ◽  
Congenital Disabilities ◽  
Labor Potential

Centering on disabled people’s experiences of complex embodiment under slavery, this chapter highlights the shifting boundaries of “unsoundness.” Enslaved people experienced congenital disabilities but also acquired impairments as a result of labor accidents, punishments, and aging. Bondpeople were valuable “property” as laborers and potential reproducers of future generations of slaves, so the condition of their bodies and minds were central to slaveholders’ pursuit of economic gain. This emphasis on sound bodies and minds dominated the historical record left by slaveholders and, in turn, shaped scholarship about the institution. Clinical and detached assessments of “slave health” and assumptions about labor potential obscure the point that many people navigated a lifetime of enslavement with various disabilities.

Part 21: Congenital disabilities Act 1976

2000 ◽  
Vol 8 (10) ◽  
pp. 653-653
Author(s):  
Bridgit Dimond
Keyword(s):  
Congenital Disabilities

scholarly journals PREVALENCE AND RISK FACTORS FOR OCCURRENCE OF CONGENITAL ANOMALIES IN NEONATES AT HOSPITAL FOR CHILD AND MATERNITY IN MISAN PROVINCE

2020 ◽  
Vol 17 (36) ◽  
pp. 1176-1185
Author(s):  
Esraa Abd Almuhsen ALI ◽  
Hussein Fadhil ALJAWADI
Keyword(s):  
Risk Factors ◽  
Birth Defects ◽  
Health Care Systems ◽  
Action Plan ◽  
Central Nervous System Involvement ◽  
Cross Sectional Study ◽  
Considerable Effect ◽  
Cross Sectional ◽  
Care Systems ◽  
Congenital Disabilities

Congenital disabilities affect a remarkable proportion of neonates and have a significant role in hospital admission, morbidity, and pediatrics mortality. Besides, the long-term morbidity and disability caused by birth defects may have a considerable effect on the development of the child and family and health care systems. In Misan, congenital disabilities are considered a third common cause of neonatal mortality. This study aimed to estimate the prevalence, types, and risk factors of congenital disabilities to have an action plan toward preventing the occurrence of these defects. A cross-sectional study performed in the neonatal care unit in Misan Hospital for Child and Maternity during the period of two years (2018 and 2019). Misan province is located in the South East of Iraq. The information was collected from the files of patients and registration records. Any delivered a live neonate with birth defects was enrolled in this study. These cases were diagnosed depending on history, clinical examination supported by other investigations, and radiographic studies whenever needed. The prevalence rates of congenital disabilities were 7.1/1000 and 6.6/1000 live birth in 2018 and 2019, respectively. Central nervous system involvement was the most typical pattern. Congenital disabilities were more frequent in male, single, and term babies of maternal age 18-35 years living in an urban area with a consanguinity history. Thus, the prevalence rate of congenital disabilities was notably high in Misan. Efforts toward prevention, as well as improving the prenatal diagnosis, would be essential.

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