Morphogenesis and cellular proliferation pattern in the developing antennal lobe of Drosophila melanogaster

1995 ◽  
Vol 205 (1-2) ◽  
pp. 62-72 ◽  
Author(s):  
Reinhard F. Stocker ◽  
Madeleine Tissot ◽  
Nana� Gendre
Keyword(s):  
Drosophila Melanogaster ◽  
Antennal Lobe ◽  
Cellular Proliferation

scholarly journals Apis mellifera octopamine receptor 1 (AmOA1) expression in antennal lobe networks of the honey bee (Apis mellifera) and fruit fly (Drosophila melanogaster)

2013 ◽  
Vol 7 ◽  
Author(s):  
Irina T. Sinakevitch ◽  
Adrian N. Smith ◽  
Fernando Locatelli ◽  
Ramon Huerta ◽  
Maxim Bazhenov ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Apis Mellifera ◽  
Honey Bee ◽  
Antennal Lobe ◽  
Fruit Fly ◽  
Octopamine Receptor

scholarly journals Z4-11Al mediates olfactory attraction and courtship in Drosophila melanogaster

2021 ◽  
Author(s):  
Felipe Borrero-Echeverry ◽  
Marit Solum ◽  
Federica Trona ◽  
Erika A. Wallin ◽  
Marie Bengtsson ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Antennal Lobe ◽  
Ecological Niches ◽  
Olfactory Communication ◽  
Social Signals ◽  
Active Components ◽  
Activation Patterns ◽  
Male And Female ◽  
Upwind Flight ◽  
Female Pheromone

Specific mate communication and recognition underlies reproduction and hence speciation. Mate communication evolves during adaptation to ecological niches and makes use of social signals and habitat cues. Our study provides new insights in Drosophila melanogaster premating olfactory communication, showing that female pheromone Z4-11Al and male pheromone cVA interact with food odour in a sex-specific manner. Furthermore, Z4-11Al, which mediates upwind flight attraction in both sexes, also elicits courtship in experienced males. Twin variants of the olfactory receptor Or69a are co-expressed in the same olfactory sensory neurons, and feed into the same glomerulus in the antennal lobe. Female pheromone Z4-11Al is perceived via Or69aB, while the food odorant (R)-linalool is a main ligand for the other variant, Or69aA. That Z4-11Al mediates courtship in experienced males, not (R)-linalool, is probably due to courtship learning. Behavioural discrimination is reflected by calcium imaging of the antennal lobe, showing distinct glomerular activation patterns by these two compounds. Male sex pheromone cVA is known to affect male and female courtship at close range, but does not elicit upwind flight attraction as a single compound, in to contrast to Z4-11Al. A blend of cVA and the food odour vinegar attracted females, while a blend of female pheromone Z4-11Al and vinegar attracted males instead. Sex-specific upwind flight attraction to blends of food volatiles and male and female pheromone, respectively, adds a new element to Drosophila olfactory premating communication and is an unambiguous paradigm for identifying the behaviourally active components, towards a more complete concept of food-pheromone odour objects.

Olfactory Microcircuits in Drosophila Melanogaster

2017 ◽  
pp. 361-368
Author(s):  
Jürgen Rybak ◽  
Bill S. Hansson
Keyword(s):  
Drosophila Melanogaster ◽  
Sensory Neurons ◽  
Mushroom Body ◽  
Antennal Lobe ◽  
Odorant Receptor ◽  
Second Order ◽  
Projection Neurons ◽  
Order Processing ◽  
Vinegar Fly ◽  
Maxillary Palps

In the vinegar fly (Drosophila melanogaster), the neuronal pathway that processes olfactory information is organized into multiple layers: a peripheral set of olfactory sensory neurons (OSNs); the primary olfactory center, or antennal lobe (AL); and two second-order neuropils, the mushroom body (MB) and lateral horn (LH). Odorants are detected by the dendrites of OSNs housed in sensilla on the maxillary palps and antennae. The OSN axons converge onto spherical synaptic neuropil within the AL termed glomeruli. OSNs that express the same odorant receptor project to the same glomerulus in a one-to-one fashion, forming discrete olfactory pathways. In the AL, a network of local interneurons (LNs) and projection neurons (PNs) contribute to the first-order processing within the glomeruli. Two types of PNs constitute the principal, parallel output pathways made by PN axons that end in the second-order neuropils of the MB and LH: uniglomerular PNs (uPNs) and multiglomerular PNs (mPNs).

scholarly journals The Reaper-Binding Protein Scythe Modulates Apoptosis and Proliferation during Mammalian Development

2005 ◽  
Vol 25 (23) ◽  
pp. 10329-10337 ◽  
Author(s):  
Fabienne Desmots ◽  
Helen R. Russell ◽  
Youngsoo Lee ◽  
Kelli Boyd ◽  
Peter J. McKinnon
Keyword(s):  
Cell Death ◽  
Drosophila Melanogaster ◽  
Programmed Cell Death ◽  
Xenopus Laevis ◽  
Cellular Proliferation ◽  
Nuclear Protein ◽  
Normal Development ◽  
Mammalian Development ◽  
Developmental Defects ◽  
Cell Extracts

ABSTRACT Scythe (BAT3 [HLA-B-associated transcript 3]) is a nuclear protein that has been implicated in apoptosis, as it can modulate Reaper, a central apoptotic regulator in Drosophila melanogaster. While Scythe can markedly affect Reaper-dependent apoptosis in Xenopus laevis cell extracts, the function of Scythe in mammals is unknown. Here, we report that inactivation of Scythe in the mouse results in lethality associated with pronounced developmental defects in the lung, kidney, and brain. In all cases, these developmental defects were associated with dysregulation of apoptosis and cellular proliferation. Scythe − / − cells were also more resistant to apoptosis induced by menadione and thapsigargin. These data show that Scythe is critical for viability and normal development, probably via regulation of programmed cell death and cellular proliferation.

scholarly journals Drosophila Olfaction

2018 ◽  
Author(s):  
Quentin Gaudry ◽  
Jonathan Schenk
Keyword(s):  
Drosophila Melanogaster ◽  
Antennal Lobe ◽  
Physiological Activity ◽  
Cell Types ◽  
Model System ◽  
Sensory Coding ◽  
Cell Numbers ◽  
Olfactory Systems ◽  
Endogenous Proteins ◽  
The Brain

Olfactory systems are tasked with converting the chemical environment into electrical signals that the brain can use to optimize behaviors such as navigating towards resources, finding mates, or avoiding danger. Drosophila melanogaster has long served as a model system for several attributes of olfaction. Such features include sensory coding, development, and the attempt to link sensory perception to behavior. The strength of Drosophila as a model system for neurobiology lies in the myriad of genetic tools made available to the experimentalist, and equally importantly, the numerical reduction in cell numbers within the olfactory circuit. Modern techniques have recently made it possible to target nearly all cell types in the antennal lobe to directly monitor their physiological activity or to alter their expression of endogenous proteins or transgenes.

Spatial coding of olfactory information in the antennal lobe of Drosophila melanogaster

1988 ◽  
Vol 453 (1-2) ◽  
pp. 299-307 ◽  
Author(s):  
Veronica Rodrigues
Keyword(s):  
Drosophila Melanogaster ◽  
Antennal Lobe ◽  
Spatial Coding ◽  
Olfactory Information

scholarly journals orco mutagenesis causes loss of antennal lobe glomeruli and impaired social behavior in ants

2017 ◽  
Author(s):  
Waring Trible ◽  
Ni-Chen Chang ◽  
Benjamin J Matthews ◽  
Sean K McKenzie ◽  
Leonora Olivos-Cisneros ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Social Behavior ◽  
Antennal Lobe ◽  
Social Cues ◽  
Odorant Receptors ◽  
Receptor Function ◽  
Ant Colonies ◽  
Olfactory Processing ◽  
Mutant Lines ◽  
Pheromone Perception

Life inside ant colonies is orchestrated with a diverse set of pheromones, but it is not clear how ants perceive these social cues. It has been proposed that pheromone perception in ants evolved via expansions in the numbers of odorant receptors (ORs) and antennal lobe glomeruli. Here we generate the first mutant lines in ants by disrupting orco, a gene required for the function of all ORs. We find that orco mutants exhibit severe deficiencies in social behavior and fitness, suggesting that they are unable to perceive pheromones. Surprisingly, unlike in Drosophila melanogaster, orco mutant ants also lack most of the approximately 500 antennal lobe glomeruli found in wild-types. These results illustrate that ORs are essential for ant social organization, and raise the possibility that, similar to mammals, receptor function is required for the development and/or maintenance of the highly complex olfactory processing areas in the ant brain.

scholarly journals A resource for the Drosophila antennal lobe provided by the connectome of glomerulus VA1v

eLife ◽  
2018 ◽  
Vol 7 ◽  
Author(s):  
Jane Anne Horne ◽  
Carlie Langille ◽  
Sari McLin ◽  
Meagan Wiederman ◽  
Zhiyuan Lu ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Olfactory Receptor ◽  
Antennal Lobe ◽  
Olfactory Receptor Neurons ◽  
Projection Neurons ◽  
Sexually Dimorphic ◽  
Genetic Screens ◽  
Local Interneurons ◽  
Receptor Neurons ◽  
The Right

Using FIB-SEM we report the entire synaptic connectome of glomerulus VA1v of the right antennal lobe in Drosophila melanogaster. Within the glomerulus we densely reconstructed all neurons, including hitherto elusive local interneurons. The fruitless-positive, sexually dimorphic VA1v included >11,140 presynaptic sites with ~38,050 postsynaptic dendrites. These connected input olfactory receptor neurons (ORNs, 51 ipsilateral, 56 contralateral), output projection neurons (18 PNs), and local interneurons (56 of >150 previously reported LNs). ORNs are predominantly presynaptic and PNs predominantly postsynaptic; newly reported LN circuits are largely an equal mixture and confer extensive synaptic reciprocity, except the newly reported LN2V with input from ORNs and outputs mostly to monoglomerular PNs, however. PNs were more numerous than previously reported from genetic screens, suggesting that the latter failed to reach saturation. We report a matrix of 192 bodies each having >50 connections; these form 88% of the glomerulus’ pre/postsynaptic sites.

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