Effect of catechol oestrogens on extraneuronal metabolism of noradrenaline by rabbit uterine endometrium and myometrium

1991 ◽  
Vol 343 (3) ◽  
Author(s):  
J.A. Kennedy
Keyword(s):  
Uterine Endometrium ◽  
Metabolism Of Noradrenaline ◽  
Extraneuronal Metabolism

Effect of progesterone on the metabolism of noradrenaline in rabbit uterine endometrium and myometrium

1986 ◽  
Vol 333 (4) ◽  
pp. 368-376 ◽  
Author(s):  
J. A. Kennedy ◽  
I. S. de la Lande
Keyword(s):  
Uterine Endometrium ◽  
Metabolism Of Noradrenaline

Inhibition of the Extraneuronal Metabolism of Noradrenaline in the Isolated Heart by Adrenergic Blocking Agents

Nature ◽  
1967 ◽  
Vol 213 (5073) ◽  
pp. 297-298 ◽  
Author(s):  
ARNOLD J. EISENFELD ◽  
LAWRENCE KRAKOFF ◽  
LESLIE L. IVERSEN ◽  
JULIUS AXELROD
Keyword(s):  
Isolated Heart ◽  
Blocking Agents ◽  
Metabolism Of Noradrenaline ◽  
Extraneuronal Metabolism ◽  
Adrenergic Blocking ◽  
Adrenergic Blocking Agents

Inhibition of TMEM16A impedes embryo implantation and decidualization in mice

Reproduction ◽  
2018 ◽  
Author(s):  
Qianrong Qi ◽  
Yifan Yang ◽  
Kailin Wu ◽  
Qingzhen Xie
Keyword(s):  
Progesterone Receptor ◽  
Stromal Cells ◽  
Embryo Implantation ◽  
Mouse Uterus ◽  
Endometrial Stromal Cells ◽  
Uterine Endometrium ◽  
Molecule Inhibitor ◽  
Pathway Inhibition ◽  
And Function ◽  
Reproductive Processes

Recent studies revealed that TMEM16A is involved in several reproductive processes, including ovarian estrogen secretion and ovulation, sperm motility and acrosome reaction, fertilization, and myometrium contraction. However, little is known about the expression and function of TMEM16A in embryo implantation and decidualization. In this study, we focused on the expression and regulation of TMEM16A in mouse uterus during early pregnancy. We found that TMEM16A is up-regulated in uterine endometrium in response to embryo implantation and decidualization. Progesterone treatment could induce TMEM16A expression in endometrial stromal cells through progesterone receptor/c-Myc pathway, which is blocked by progesterone receptor antagonist or the inhibitor of c-Myc signaling pathway. Inhibition of TMEM16A by small molecule inhibitor (T16Ainh-A01) resulted in impaired embryo implantation and decidualization in mice. Treatment with either specific siRNA of Tmem16a or T16Ainh-A01 inhibited the decidualization and proliferation of mouse endometrial stromal cells. In conclusion, our results revealed that TMEM16A is involved in embryo implantation and decidualization in mice, compromised function of TMEM16A may lead to impaired embryo implantation and decidualization.

scholarly journals Three-dimensional understanding of the morphological complexity of the human uterine endometrium

iScience ◽  
2021 ◽  
pp. 102258
Author(s):  
Manako Yamaguchi ◽  
Kosuke Yoshihara ◽  
Kazuaki Suda ◽  
Hirofumi Nakaoka ◽  
Nozomi Yachida ◽  
...  
Keyword(s):  
Three Dimensional ◽  
Morphological Complexity ◽  
Uterine Endometrium ◽  
Human Uterine Endometrium

scholarly journals Exaptation of Retroviral Syncytin for Development of Syncytialized Placenta, Its Limited Homology to the SARS-CoV-2 Spike Protein and Arguments against Disturbing Narrative in the Context of COVID-19 Vaccination

Biology ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 238
Author(s):  
Malgorzata Kloc ◽  
Ahmed Uosef ◽  
Jacek Z. Kubiak ◽  
Rafik M. Ghobrial
Keyword(s):  
Cell Membrane ◽  
Host Cell ◽  
Envelope Glycoprotein ◽  
Mammalian Species ◽  
Viral Envelope ◽  
Spike Protein ◽  
Mammalian Evolution ◽  
Trophoblast Cells ◽  
Host Cell Membrane ◽  
Uterine Endometrium

Human placenta formation relies on the interaction between fused trophoblast cells of the embryo with uterine endometrium. The fusion between trophoblast cells, first into cytotrophoblast and then into syncytiotrophoblast, is facilitated by the fusogenic protein syncytin. Syncytin derives from an envelope glycoprotein (ENV) of retroviral origin. In exogenous retroviruses, the envelope glycoproteins coded by env genes allow fusion of the viral envelope with the host cell membrane and entry of the virus into a host cell. During mammalian evolution, the env genes have been repeatedly, and independently, captured by various mammalian species to facilitate the formation of the placenta. Such a shift in the function of a gene, or a trait, for a different purpose during evolution is called an exaptation (co-option). We discuss the structure and origin of the placenta, the fusogenic and non-fusogenic functions of syncytin, and the mechanism of cell fusion. We also comment on an alleged danger of the COVID-19 vaccine based on the presupposed similarity between syncytin and the SARS-CoV-2 spike protein.

THE MEASUREMENT OF HIGH-AFFINITY OESTRADIOL RECEPTORS IN HUMAN UTERINE ENDOMETRIUM AND MYOMETRIUM

1971 ◽  
Vol 68 (3) ◽  
pp. 534-542 ◽  
Author(s):  
D. M. Robertson ◽  
J. Mešter ◽  
J. Beilby ◽  
S. J. Steele ◽  
A. E. Kellie
Keyword(s):  
Menstrual Cycle ◽  
Normal Range ◽  
Biopsy Material ◽  
Uterine Endometrium ◽  
High Affinity ◽  
Biopsy Tissue ◽  
Receptor Sites ◽  
Receptor Concentration ◽  
Human Uterine Endometrium

ABSTRACT The concentration of unoccupied high-affinity oestradiol receptors in the cytosol of human uterine endometrial curettings and biopsy tissue has been determined. In normal specimens, where the day of the menstrual cycle could be assessed histologically, a variation of tissue receptor concentration throughout the cycle was observed showing a maximum at mid-cycle and minima at the beginning and end of the cycle. The distribution of oestradiol receptor sites in the endometrium and myometrium along the length of the uterus has also been studied. Highest concentrations in the endometrium were found in the fundus and these levels fell progressively to negligible concentrations in the isthmus and cervix. In general, the concentration of receptor sites in biopsy material was lower than in curettings and this observation has been related on the region of the uterus from which the samples were obtained. The concentration of receptor sites in abnormal uterine specimens lay within the normal range.

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