Effects of fasting and food restriction on sympathetic activity in brown adipose tissue in mice

1992 ◽  
Vol 162 (7) ◽  
pp. 602-606 ◽  
Author(s):  
M. A. Griggio ◽  
D. Richard ◽  
J. Leblanc
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Sympathetic Activity ◽  
Food Restriction ◽  
Brown Adipose

Effects of fasting and food restriction on brown adipose tissue composition in normal and dystrophic hamsters

1986 ◽  
Vol 64 (7) ◽  
pp. 970-975 ◽  
Author(s):  
M. Desautels ◽  
R. A. Dulos ◽  
H. M. Yuen
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Food Deprivation ◽  
Food Restriction ◽  
Tissue Mass ◽  
Tissue Protein ◽  
Guanosine Diphosphate ◽  
Isolated Mitochondria ◽  
Daily Food ◽  
Brown Adipose

Fasting for 36–48 h or food restriction (30% reduction of daily food intake for 6 weeks) caused brown adipose tissue (BAT) atrophy in hamsters. Fasting-induced atrophy was characterized by reductions in tissue mass, DNA, protein, and thermogenin. By contrast, food restriction had no effect on tissue cellularity (DNA) but markedly reduced the tissue protein and thermogenin contents. The concentration of thermogenin in isolated mitochondria was unchanged by fasting or food restriction. Dystrophic hamsters had a reduced BAT mass when compared with weight-matched control hamsters. This resulted from a reduction in tissue cellularity since BAT DNA, protein and thermogenin contents were all reduced. The extent of binding of [3H]guanosine diphosphate to isolated mitochondria and their content of thermogenin were similar in normal and dystrophic hamsters. In response to cold exposure, as in normal hamsters, BAT of dystrophic hamsters grew and the tissue thermogenin increased, but the mitochondrial concentration of thermogenin did not change. In response to fasting, in contrast with normal hamsters, there was no significant reduction in BAT DNA in dystrophic animals and the loss of tissue protein was reduced. However, the relative changes in BAT composition during chronic food restriction were similar in normal and dystrophic animals. Thus, reduction in hamster BAT thermogenic capacity during food deprivation may occur by loss of cells and (or) reduction in the tissue protein and thermogenin contents. The extent of protein and (or) DNA loss may be dependent upon the original tissue mass and the severity of food deprivation.

scholarly journals Low protein diet changes the energetic balance and sympathetic activity in brown adipose tissue of growing rats

Nutrition ◽  
2009 ◽  
Vol 25 (11-12) ◽  
pp. 1186-1192 ◽  
Author(s):  
Suélem Aparecida de França ◽  
Maísa Pavani dos Santos ◽  
Maria Antonieta Rissato Garófalo ◽  
Luiz Carlos Navegantes ◽  
Isis do Carmo Kettelhut ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Sympathetic Activity ◽  
Protein Diet ◽  
Low Protein Diet ◽  
Growing Rats ◽  
Low Protein ◽  
Brown Adipose ◽  
Energetic Balance

Food restriction attenuates oxidative stress in brown adipose tissue of striped hamsters acclimated to a warm temperature

2016 ◽  
Vol 58 ◽  
pp. 72-79 ◽  
Author(s):  
Ji-Ying Zhang ◽  
Xiao-Ya Zhao ◽  
Gui-Ying Wang ◽  
Chun-Ming Wang ◽  
Zhi-Jun Zhao
Keyword(s):  
Oxidative Stress ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Food Restriction ◽  
Warm Temperature ◽  
Brown Adipose

Food restriction increases torpor and improves brown adipose tissue thermogenesis in ob/ob mice

1985 ◽  
Vol 248 (5) ◽  
pp. E531-E539 ◽  
Author(s):  
J. Himms-Hagen
Keyword(s):  
Adipose Tissue ◽  
Body Temperature ◽  
Brown Adipose Tissue ◽  
Rectal Temperature ◽  
Food Restriction ◽  
Normal Body Temperature ◽  
Cold Intolerance ◽  
Brown Adipose ◽  
Brown Adipose Tissue Thermogenesis ◽  
Ad Libitum

Restricting the food intake of the genetically obese (ob/ob) mouse is known to ameliorate its cold intolerance. Cold intolerance of the ob/ob mouse is associated with defective thermogenesis in its brown adipose tissue. The objective of the experiments was to find out whether food restriction could increase the thermogenic function of brown adipose tissue of the ob/ob mouse. Obese and lean mice were fed a restricted amount of chow in one meal per day for 3-7 mo. Both lean and ob/ob mice were torpid (rectal temperature of approximately 32 degrees C) in the early morning and aroused spontaneously to a normal body temperature before the anticipated meal time. Obese mice were also torpid during the dark phase, whereas lean mice were active and had a normal body temperature at this time. Brown adipose tissue was in a thermogenically inactive state (low level of mitochondrial GDP binding) in torpid lean and ob/ob mice but became thermogenically active (increase in mitochondrial GDP binding) during stimulated arousal when body temperature increased by 6-7 degrees C in 15-30 min. Ad libitum-fed ob/ob mice had a normal diurnal rhythm in a rectal temperature that was at a lower level than in lean ad libitum-fed mice. They did not raise their rectal temperatures when stimulated and no activation of brown adipose tissue thermogenesis occurred under these conditions. Food restriction increased the capacity of both lean and ob/ob mice to raise their metabolic rate in response to injection of noradrenaline, indicating an increased capacity for thermogenesis in their brown adipose tissue.(ABSTRACT TRUNCATED AT 250 WORDS)

Dissociation between brown adipose tissue thermogenesis and sympathetic activity in rats with high plasma levels of oestradiol

1994 ◽  
Vol 426 (1-2) ◽  
pp. 40-43 ◽  
Author(s):  
Mar�a Paz Nava ◽  
Alberto Fern�ndez ◽  
Mar�a Abelenda ◽  
Marisa Puerta
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Plasma Levels ◽  
Sympathetic Activity ◽  
High Plasma ◽  
Brown Adipose ◽  
Brown Adipose Tissue Thermogenesis

Sympathetic activity in brown adipose tissue from rats adapted to a high protein, carbohydrate-free diet

1998 ◽  
Vol 69 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Marcia N Brito ◽  
Nilton A Brito ◽  
Maria A.R Garófalo ◽  
Isis C Kettelhut ◽  
Renato H Migliorini
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Sympathetic Activity ◽  
High Protein ◽  
Brown Adipose

Plasticity in food intake, thermogenesis and body mass in the tree shrew (Tupaia belangeri) is affected by food restriction and refeeding

2016 ◽  
Vol 66 (2) ◽  
pp. 201-217 ◽  
Author(s):  
Wen-rong Gao ◽  
Wan-long Zhu ◽  
Fang-yan Ye ◽  
Mu-lin Zuo ◽  
Zheng-kun Wang
Keyword(s):  
Adipose Tissue ◽  
Food Intake ◽  
Brown Adipose Tissue ◽  
Body Mass ◽  
Food Restriction ◽  
Uncoupling Protein ◽  
Tissue Mass ◽  
Serum Leptin ◽  
Brown Adipose ◽  
Ad Libitum

Physiological adjustments are important strategies for small mammals in response to variation in food availability. To determine the physiological mechanisms affected by food restriction and refeeding, tree shrews were restricted to 85% of initial food intake for 4 weeks and refedad libitumfor another 4 weeks. Changes in food intake, body mass, thermogenesis, body composition, mitochondrial cytochromecoxidase activity, uncoupling protein-1 content in brown adipose tissue and serum leptin levels were measured. The results showed that body mass, body fat mass and serum leptin levels significantly decreased in food restricted tree shrews, and increased when the restriction ended, showing a short “compensatory growth” rather than over-weight or obesity compared withad libitumcontrols. Resting metabolic rate, non-shivering thermogenesis, brown adipose tissue mass (mg), and uncoupling protein-1 content decreased significantly in response to food restriction, and returned to the control levels after the animals were refedad libitum, while the brown adipose tissue mass (%) and cytochromecoxidase activity remained stable during food restriction and refeeding. Food intake increased shortly after refeeding, which perhaps contributed to the rapid regaining of body mass. These results suggest thatTupaia belangerican adjust the status of its physiology integratively to cope with the lack of food by means of decreasing body mass, thermogenesis and serum leptin levels. Leptin may act as a starvation signal to predominantly mediate the reduction in body mass and energy expenditure.

scholarly journals Sympathetic activity and functional masking of brown adipose tissue uncoupling protein

1992 ◽  
Vol 32 (5-6) ◽  
pp. 499-499
Author(s):  
M. Goubern ◽  
MF Chapey ◽  
MC Laury ◽  
R. Portet
Keyword(s):  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Sympathetic Activity ◽  
Uncoupling Protein ◽  
Brown Adipose
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