scholarly journals Studies on autoimmunity for initiation of Beta-cell destruction VIII. Pancreatic Beta-cell dependent autoantibody to a 38 kilodalton protein precedes the clinical onset of diabetes in BB rats

Diabetologia ◽  
1991 ◽  
Vol 34 (8) ◽  
pp. 548-554 ◽  
Author(s):  
I. Y. Ko ◽  
S. H. Ihm ◽  
J. W. Yoon
Keyword(s):  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Beta Cell Destruction ◽  
Cell Destruction ◽  
Clinical Onset ◽  
Bb Rats ◽  
Onset Of Diabetes

scholarly journals Prevention and suppression of autoimmune pancreatic Beta-cell destruction in BB rats by syngeneic lymphocytes obtained from long-term normoglycaemic donors

Diabetologia ◽  
1991 ◽  
Vol 34 (2) ◽  
pp. 74-77 ◽  
Author(s):  
B. Kuttler ◽  
A. Dunger ◽  
H. D. Volk ◽  
T. Diamantstein ◽  
H. J. Hahn
Keyword(s):  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Beta Cell Destruction ◽  
Cell Destruction ◽  
Bb Rats

scholarly journals Vildagliptin Ameliorates Oxidative Stress and Pancreatic Beta Cell Destruction in Type 1 Diabetic Rats

2013 ◽  
Vol 44 (3) ◽  
pp. 194-202 ◽  
Author(s):  
Danielle de Lima Ávila ◽  
Glaucy Rodrigues de Araújo ◽  
Maisa Silva ◽  
Pedro Henrique de Amorim Miranda ◽  
Mirla Fiuza Diniz ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Diabetic Rats ◽  
Beta Cell Destruction ◽  
Cell Destruction

Mice lacking the poly(ADP-ribose) polymerase gene are resistant to pancreatic beta-cell destruction and diabetes development induced by streptozocin

10.1038/6535 ◽  
1999 ◽  
Vol 5 (3) ◽  
pp. 314-319 ◽  
Author(s):  
Volker Burkart ◽  
Zhao-Qi Wang ◽  
Jürgen Radons ◽  
Birgit Heller ◽  
Zdenko Herceg ◽  
...  
Keyword(s):  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Polymerase Gene ◽  
Beta Cell Destruction ◽  
Cell Destruction ◽  
Diabetes Development

Serum CA19–9 Levels and Pancreatic Beta Cell Destruction in Type 2 Diabetes Mellitus Patients

2016 ◽  
Vol 14 (6) ◽  
pp. 1-6
Author(s):  
Mohammad Mansour Saif ◽  
Waddaah Al-Asbahy ◽  
Abdulkawi Al-Fakih ◽  
Adeeb Albadani
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Beta Cell ◽  
Pancreatic Beta Cell ◽  
Beta Cell Destruction ◽  
Cell Destruction

scholarly journals Faktor Risiko Kerusakan Sel Beta Pankreas Melalui Deteksi Antibodi Gad (Glutamic Acid Decarboxylase) 65 pada Perempuan di Stikes Hang Tuah Surabaya

2019 ◽  
Vol 12 (1) ◽  
Author(s):  
Nisha Dharmayanti Rinarto
Keyword(s):  
Physical Activity ◽  
Diabetes Mellitus ◽  
Risk Factor ◽  
Waist Circumference ◽  
Beta Cell ◽  
Pancreatic Beta Cells ◽  
Pancreatic Beta Cell ◽  
Beta Cell Destruction ◽  
Cell Destruction ◽  
Gad 65

Pancreatic beta cell damage is irreversible due to ongoing oxidative stress on the formation of ROS underlying pathophysiology of the phase-onset diabetes mellitus. Prevention of damage to pancreatic beta cells in diabetes mellitus onset phase through the detection of GAD 65 as an autoantigen imonogenik diabetes mellitus in human pancreas reacts with GADA can be done early. The purpose of this study analyzed the age, physical activity, cholesterol, body mass index, and waist circumference as a risk factor in the positive expression of GAD 65 women's groups in serum STIKES Hang Tuah Surabaya. This study was cross sectional study. Samples are some women in STIKES Hang Tuah Surabaya as much 40 respondents who meet the inclusion and exclusion criteria were selected through probability sampling techniques. The result of the relationship with the independent variable dependent variable using Chi Square showed that age (p = 0.395), physical activity (p = 0.572), BMI (p = 0.388), and waist circumference (p = 0.411) so it is not a risk factor for damage pancreatic beta cells. While cholesterol (p = 0.035) so it is a risk factor for pancreatic beta cell destruction. The conclusion of this study was in women aged 19-37 years with risk factors that can be used as a prediction of pancreatic beta cell destruction via antibody detection GAD 65 is high cholesterol.Keywords: Pancreatic Beta Cell Destruction, GAD 65, Women

scholarly journals Dexi disruption depletes gut microbial metabolites and accelerates autoimmune diabetes

2018 ◽  
Author(s):  
LJ Davison ◽  
MD Wallace ◽  
C Preece ◽  
K Hughes ◽  
JA Todd ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Beta Cell ◽  
Gut Microbiome ◽  
Pancreatic Beta Cell ◽  
Nod Mouse ◽  
Microbial Metabolites ◽  
Beta Cell Destruction ◽  
Cell Destruction ◽  
Autoimmune Attack

AbstractNon-coding genetic variants in the CLEC16A gene on human chromosome 16p13.13 are associated with risk of autoimmune diseases, including type 1 diabetes and multiple sclerosis. In this region, we previously identified DEXI, a candidate causal gene of unknown function, which alters the risk of type 1 diabetes, where the T1D predisposing allele is associated with lower DEXI expression. Here, we demonstrate by CRISPR mutagenesis in vivo and deep phenotyping that disrupted Dexi expression accelerates diabetes in the non-obese diabetic (NOD) mouse, a spontaneous model of autoimmune pancreatic beta-cell destruction. Mutant mice have increased serum IgM and IgA concentrations compared to wild-type NOD mice, as well as changes in both the gut microbiome and molecular metabolites associated with microbial metabolism. These findings suggest that the mechanism by which DEXI alters diabetes risk involves the composition and function of the microbiome and its impact on host metabolites. Such metabolites, including short chain fatty acids such as butyrate, have been shown to alter the activity of the immune cells involved in beta-cell destruction and susceptibility of the beta cells to autoimmune attack.One Sentence Summary: Disruption of the Dexi gene leads to accelerated diabetes in the non-obese diabetic (NOD) mouse, accompanied by changes in serum immunoglobulins, gut microbiome and microbial metabolites.

scholarly journals Enhanced Characterization of Beta Cell Mass in a Tg(Pdx1-GFP) Mouse Model of Beta Cell Destruction

2021 ◽  
Author(s):  
Fatemeh Karami ◽  
Behrouz Asgari Abibeiglou ◽  
Saghar Pahlavanneshan ◽  
Ali Farrokhi ◽  
Amin Tamadon ◽  
...  
Keyword(s):  
Mouse Model ◽  
Beta Cell ◽  
Transgenic Mouse ◽  
Beta Cells ◽  
Mass Measurement ◽  
Pancreatic Beta Cell ◽  
Cell Mass ◽  
Beta Cell Mass ◽  
Beta Cell Destruction ◽  
Cell Destruction

Abstract IntroductionMeasurement of pancreatic beta cell mass in animal models is a common assay in diabetes researches. Novel whole-organ clearance methods in conjunction with transgenic mouse models hold tremendous promise to improve methods for beta cell mass measurement. Here, we propose a refined method to estimate the beta cell mass using a new transgenic Tg(Pdx1-GFP) mouse model and a recently developed free-of-acrylamide clearing tissue (FACT) protocol. MethodsFirst, we generated and evaluated a Tg(Pdx1-GFP) transgenic mouse model. By using the FACT protocol in this model, we could quantify the beta cell mass and alloxan-induced beta cell destruction in whole pancreas specimens.ResultsTg(Pdx1-GFP) transgenic mice expressed green fluorescent protein (GFP) only in the beta cells of the pancreas and limited to the beta cells. This GFP expression enabled us to accurately measure beta cell loss in a beta cell destruction model. The results suggest that our proposed method can be used as a simple, rapid assay for beta cell mass measurement in studies of islet biology and diabetes.ConclusionThe Tg(Pdx1-GFP) transgenic mouse in conjunction with the FACT protocol can enhance large-scale screening studies in the field of diabetes.

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