The prognostic value of hypocholesterolemia in hospitalized patients

1994 ◽  
Vol 72 (12) ◽  
pp. 939-943 ◽  
Author(s):  
E. Windler ◽  
U. Ewers-Grabowl ◽  
J. Thiery ◽  
A. Walli ◽  
D. Seidel ◽  
...  
2021 ◽  
Vol 8 ◽  
Author(s):  
Pei-Pei Zheng ◽  
Si-Min Yao ◽  
Di Guo ◽  
Ling-ling Cui ◽  
Guo-Bin Miao ◽  
...  

Background: The prevalence and prognostic value of heart failure (HF) stages among elderly hospitalized patients is unclear.Methods: We conducted a prospective, observational, multi-center, cohort study, including hospitalized patients with the sample size of 1,068; patients were age 65 years or more, able to cooperate with the assessment and to complete the echocardiogram. Two cardiologists classified all participants in various HF stages according to 2013 ACC/AHA HF staging guidelines. The outcome was rate of 1-year major adverse cardiovascular events (MACE). The Kaplan–Meier method and Cox proportional hazards models were used for survival analyses. Survival classification and regression tree analysis were used to determine the optimal cutoff of N-terminal pro-brain natriuretic peptide (NT-proBNP) to predict MACE.Results: Participants' mean age was 75.3 ± 6.88 years. Of them, 4.7% were healthy and without HF risk factors, 21.0% were stage A, 58.7% were stage B, and 15.6% were stage C/D. HF stages were associated with worsening 1-year survival without MACE (log-rank χ2 = 69.62, P < 0.001). Deterioration from stage B to C/D was related to significant increases in HR (3.636, 95% CI, 2.174–6.098, P < 0.001). Patients with NT-proBNP levels over 280.45 pg/mL in stage B (HR 2; 95% CI 1.112–3.597; P = 0.021) and 11,111.5 pg/ml in stage C/D (HR 2.603, 95% CI 1.014–6.682; P = 0.047) experienced a high incidence of MACE adjusted for age, sex, and glomerular filtration rate.Conclusions : HF stage B, rather than stage A, was most common in elderly inpatients. NT-proBNP may help predict MACE in stage B.Trial Registration: ChiCTR1800017204; 07/18/2018.


2017 ◽  
Vol 18 (6) ◽  
pp. 660-666.e1 ◽  
Author(s):  
Karlijn J.G. Schulkes ◽  
Esteban T.D. Souwer ◽  
Leontine J.R. van Elden ◽  
Henk Codrington ◽  
Simone van der Sar-van der Brugge ◽  
...  

2021 ◽  
Vol 11 (1) ◽  
pp. 201
Author(s):  
Erika Olivia Boyesen ◽  
Ida Maria Balsby ◽  
Marius Henriksen ◽  
Robin Christensen ◽  
Jens Henning Rasmussen ◽  
...  

C-reactive protein (CRP) has prognostic value in hospitalized patients with COVID-19; the importance of CRP in pre-hospitalized patients remains to be tested. Methods: Individuals with symptoms of COVID-19 had a SARS-CoV-2 PCR oropharyngeal swab test, and a measurement of CRP was performed at baseline, with an upper reference range of 10 mg/L. After 28 days, information about possible admissions, oxygen treatments, transfers to the ICU, or deaths was obtained from the patient files. Using logistic regression, the prognostic value of the CRP and SARS-CoV-2 test results was evaluated. Results: Among the 1006 patients included, the SARS-CoV-2 PCR test was positive in 59, and the CRP level was elevated (>10 mg/L) in 131. In total, 59 patients were hospitalized, only 3 of whom were SARS-CoV-2 positive, with elevated CRP (n = 2) and normal CRP (n = 1). The probability of being hospitalized with elevated CRP was 4.21 (95%CI 2.38–7.43, p < 0.0001), while the probability of being hospitalized with SARS-CoV-2 positivity alone was 0.85 (95%CI 0.26–2.81, p = 0.79). Conclusions: CRP is not a reliable predictor for the course of SARS-CoV-2 infection in pre-hospitalized patients. CRP, while not a SARS-CoV-2 positive test, had prognostic value in the total population of patients presenting with COVID-19-related symptoms.


2019 ◽  
Vol 32 ◽  
pp. 118-124
Author(s):  
María Monereo-Muñoz ◽  
Esther Martín-Ponce ◽  
Rubén Hernández-Luis ◽  
Geraldine Quintero-Platt ◽  
María-Ángeles Gómez-Rodríguez-Bethencourt ◽  
...  

2006 ◽  
Vol 5 (1) ◽  
pp. 143-143
Author(s):  
B REDONDO ◽  
D PASCUALFIGAL ◽  
J HURTADO ◽  
P PENAFIEL ◽  
P TORNEL ◽  
...  

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