Antenatal diagnosis of vein of Galen aneurysmal malformation: MR study of fetal brain and postnatal follow-up

Abstract A 12-day-old infant in intractable cardiac failure due to a vein of Galen malformation was treated successfully with serial ligation of the majority of the vessels feeding the malformation. Despite some residual vascular supply to the malformation, the congestive heart failure has disappeared and growth and development have been normal over a 3-year follow-up period.

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Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth

Scientific Reports ◽

10.1038/s41598-021-81681-y ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Marion I. van den Heuvel ◽

Jasmine L. Hect ◽

Benjamin L. Smarr ◽

Tamara Qawasmeh ◽

Lance J. Kriegsfeld ◽

...

Keyword(s):

Prenatal Stress ◽

Sleep Problems ◽

Brain Connectivity ◽

Fetal Brain ◽

Brain Regions ◽

In Utero ◽

Resting State Functional Connectivity ◽

Child Sleep ◽

Maternal Prenatal Stress

AbstractChild sleep disorders are increasingly prevalent and understanding early predictors of sleep problems, starting in utero, may meaningfully guide future prevention efforts. Here, we investigated whether prenatal exposure to maternal psychological stress is associated with increased sleep problems in toddlers. We also examined whether fetal brain connectivity has direct or indirect influence on this putative association. Pregnant women underwent fetal resting-state functional connectivity MRI and completed questionnaires on stress, worry, and negative affect. At 3-year follow-up, 64 mothers reported on child sleep problems, and in the subset that have reached 5-year follow-up, actigraphy data (N = 25) has also been obtained. We observe that higher maternal prenatal stress is associated with increased toddler sleep concerns, with actigraphy sleep metrics, and with decreased fetal cerebellar-insular connectivity. Specific mediating effects were not identified for the fetal brain regions examined. The search for underlying mechanisms of the link between maternal prenatal stress and child sleep problems should be continued and extended to other brain areas.

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Dural Arteriovenous Shunt Development in Patients with Vein of Galen Malformation

Interventional Neuroradiology ◽

10.15274/inr-2014-10066 ◽

2014 ◽

Vol 20 (6) ◽

pp. 781-790 ◽

Cited By ~ 6

Author(s):

Srinivasan Paramasivam ◽

Yasunari Niimi ◽

Dan Meila ◽

Alejandro Berenstein

Keyword(s):

Dura Mater ◽

Endovascular Embolization ◽

External Carotid ◽

Vein Of Galen ◽

Arteriovenous Fistulas ◽

Sprouting Angiogenesis ◽

Multi Stage ◽

Dural Arteriovenous Shunt ◽

Age Range

Dural arteriovenous fistulas (DAVF) associated with our series of patients with vein of Galen malformations (VOGM) are analyzed and discussed. We retrospectively analyzed 87 consecutive cases of VOGM treated between May 2002 and December 2011 and identified 26 patients with DAVF. We gathered information from the clinical case records, angiographic images, MRI on presentation and during follow-up. The findings were analyzed to aid discussion. Among 87 patients treated by multi-stage endovascular embolization, age range from newborn to 19 years, 26 (30%) had DAVF. In seven patients (8%), DAVF were found on initial angiogram and were all into the VOGM. Nineteen (21%) DAVF found on follow-up angiograms were all into the VOGM and distant locations. Sprouting and non-sprouting angiogenesis resulted in the formation of a network of vessels around partially thrombosed VOGM, recruiting blood from the surrounding dura mater resulting in a secondary network on the dura mater supplied by the blood vessels of dura mater in the region or from its natural collaterals. Embolization targeting DAVFs was done in 13 (52%) with complete cure in eight (32%) and recurrence in five (20%). Among 12 non-embolized patients (48%), eight (32%) had spontaneous regression with continued treatment of VOGM. In others, the DAVF either remained stable or progressed. DAVF associated with VOGM represent the dural response to angiogenic stimuli. They are observed to regress spontaneously or mature while continuing to treat the primary feeders of VOGM. It is important to include the external carotid system during angiograms. Persistent DAVF with residual VOGM that do not have access though the pial vessels are used as a conduit to treat the dural shunt and to achieve obliteration of residual VOGM at later stages of treatment.

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Prenatal diagnosis of a giant fetal hepatic hemangioma: a case report

Case Reports in Perinatal Medicine ◽

10.1515/crpm-2015-0008 ◽

2015 ◽

Vol 4 (2) ◽

Author(s):

Alain Daher ◽

Marc Dommergues ◽

Assaad Kesrouani ◽

Claude Vibert-Guigue ◽

Jacky Nizard

Keyword(s):

Spontaneous Regression ◽

Antenatal Diagnosis ◽

Fetal Liver ◽

Color Doppler ◽

Hepatic Hemangioma ◽

Vascular Pattern ◽

Image Size ◽

Fetal Protection ◽

Cesarean Birth

AbstractWe report a case of uncomplicated giant fetal hepatic hemangioma with a good outcome. A 57×38 mm heterogeneous hepatic mass, mostly hypoechogenic was observed post prenatal ultrasound, at 33 weeks’ gestation (WG) and 5 days. Color Doppler confirmed the vascular pattern of the mass. The image size stayed stable, with no associated complications, and a cesarean birth at 37 WG was performed for fetal protection. Subsequent postnatal follow-up showed spontaneous regression of the tumor. Antenatal diagnosis and management of fetal liver masses are discussed in this paper. This case supports the hypothesis that complications of giant fetal hepatic hemangioma are not related only to its size. Prognostic factors and guidelines for follow-up need to be determined.

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Choroid plexus tumors: Antenatal diagnosis and follow-up

Journal of Clinical Ultrasound ◽

10.1002/jcu.1870180709 ◽

1990 ◽

Vol 18 (7) ◽

pp. 575-578 ◽

Cited By ~ 8

Author(s):

G. Body ◽

E. Darnis ◽

J. H. Soutoul ◽

D. Pourcelot ◽

J. J. Santini ◽

...

Keyword(s):

Choroid Plexus ◽

Antenatal Diagnosis ◽

Choroid Plexus Tumors

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Fetal abdominal cysts: antenatal course and postnatal outcomes

Journal of Perinatal Medicine ◽

10.1515/jpm-2018-0311 ◽

2019 ◽

Vol 47 (4) ◽

pp. 418-421

Author(s):

Elisabetta Sanna ◽

Stavros Loukogeorgakis ◽

Thomas Prior ◽

Iris Derwig ◽

Gowrishankar Paramasivam ◽

...

Keyword(s):

Gestational Age ◽

Surgical Intervention ◽

Antenatal Diagnosis ◽

Age At Diagnosis ◽

Single Centre ◽

Intestinal Origin ◽

Abdominal Cyst

Abstract Background There is little information on which to base the prognostic counselling as to whether an antenatally diagnosed fetal abdominal cyst will grow or shrink, or need surgery. This study aims to provide contemporary data on prenatally diagnosed fetal abdominal cysts in relation to their course and postnatal outcomes. Methods Fetal abdominal cysts diagnosed over 11 years in a single centre were identified. The gestational age at diagnosis and cyst characteristics at each examination were recorded (size, location, echogenity, septation and vascularity) and follow-up data from postnatal visits were collected. Results Eighty abdominal cysts were identified antenatally at 28+4 weeks (range 11+0–38+3). Most (87%) were isolated and the majority were pelvic (52%), simple (87.5%) and avascular (100%). Antenatally, 29% resolved spontaneously; 29% reduced in size; 9% were stable and 33% increased in size. Forty-one percent of cysts under 20 mm diameter increased in size, while only 20% of cysts with a diameter of over 40 mm increased in size. The majority of cysts were ovarian in origin (n=45, 56%), followed by intestinal (n=15, 18%), choledochal (n=3, 4%), liver (n=2, 3%) and renal/adrenal origins (n=2, 3%), respectively. In 16% (n=13), the antenatal diagnosis was not obvious. Seventy-five percent of the cysts that persisted postnatally required surgical intervention. Conclusion Most antenatally diagnosed fetal abdominal cysts were ovarian in origin. Though most disappeared antenatally, nearly three quarters required surgical intervention when present after birth. Cysts of intestinal origin are more difficult to diagnose antenatally and often require surgery.

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Fetal Cholelithiasis: Antenatal Diagnosis and Neonatal Follow-Up in a Case of Twin Pregnancy – A Case Report and Review of the Literature

Ultrasound International Open ◽

10.1055/s-0042-123840 ◽

2017 ◽

Vol 03 (01) ◽

pp. E8-E12 ◽

Cited By ~ 3

Author(s):

Yannick Hurni ◽

Francesco Vigo ◽

Begoña von Wattenwyl ◽

Nicole Ochsenbein ◽

Claudia Canonica

Keyword(s):

Case Report ◽

Twin Pregnancy ◽

Antenatal Diagnosis ◽

Review Of The Literature

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A Screening and Intervention Program Reducing Mortality and Serious Morbidity Associated with Neonatal Alloimmune Thrombocytopenia.

Blood ◽

10.1182/blood.v106.11.1232.1232 ◽

2005 ◽

Vol 106 (11) ◽

pp. 1232-1232

Author(s):

Jens Kjeldsen-Kragh ◽

Mette K. Killie ◽

Geir Tomter ◽

Elzbieta Golebiowska ◽

Helene Pedersen ◽

...

Keyword(s):

Platelet Count ◽

Intervention Program ◽

Human Platelet ◽

Fetal Brain ◽

University Hospital ◽

Severe Thrombocytopenia ◽

Platelet Antigen ◽

Human Platelet Antigen ◽

Alloimmune Thrombocytopenia

Abstract Background: Neonatal alloimmune thrombocytopenia (NAIT) is most frequently caused by antibodies against the human platelet antigen (HPA) 1a. The objective of the present study was to identify HPA 1a negative women, and to offer them an intervention program aimed to reduce morbidity and mortality of NAIT. Methods: A total of 100,448 pregnant women were HPA 1 typed. The HPA 1a negative women were screened for anti-HPA 1a, which was quantified when present. Immunized women were referred to a university hospital for clinical follow-up, including ultrasonographic examination of the fetal brain. Caesarean section was performed 2–4 weeks prior to term with platelets from HPA 1bb donors reserved for immediate transfusion if petechiae were present and/or if platelet count was < 35 × 109/L. Results: Of all women typed 2.1% were HPA 1a negative. Anti-HPA 1a was detected in 210 of 1,990 HPA 1a negative women. A total of 170 pregnancies in 154 HPA 1a negative women were managed according to the intervention program. These women gave birth to 161 HPA 1a positive children of whom 55 had severe thrombocytopenia (<50 × 109/L) including two with ICH. There were no intrauterine deaths. In 13 previously published prospective studies comprising 131,465 women of whom 2,290 were HPA 1a negative, there were 10 cases with severe NAIT-related complications (3 intrauterine deaths and 7 neonates with ICH), which are significantly higher than in our study (p < 0.05). Conclusions: The screening and intervention program seems to reduce mortality and serious morbidity associated with NAIT.

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