Correlation between cellular and humoral immune responses to different doses of sheep's red blood cells in mice

1991 ◽  
Vol 112 (3) ◽  
pp. 1278-1281
Author(s):  
E. Yu. Gusev ◽  
V. L. Ponosov ◽  
N. N. Kevorkov
Keyword(s):  
Immune Responses ◽  
Red Blood Cells ◽  
Blood Cells ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Sheep's Red Blood Cells ◽  
Different Doses

Tolerance induction by lentiviral gene therapy with a nonmyeloablative regimen

Blood ◽  
2006 ◽  
Vol 107 (6) ◽  
pp. 2286-2293 ◽  
Author(s):  
Noboru Mitsuhashi ◽  
Jacqueline Fischer-Lougheed ◽  
Irina Shulkin ◽  
Annette Kleihauer ◽  
Donald B. Kohn ◽  
...  
Keyword(s):  
Immune Responses ◽  
Blood Cells ◽  
Lentiviral Vector ◽  
Lethal Dose ◽  
Tolerance Induction ◽  
Xenograft Rejection ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Lentiviral Gene Therapy

AbstractAntibodies (Abs) directed at the Galα1,3Galβ1,4GlcNAc-R (αGal) carbohydrate epitope initiate xenograft rejection. Previously, we have shown that bone marrow transplantation (BMT) with lentivirus-mediated gene transfer of porcine α1,3 galactosyltransferase (GalT) is able to induce tolerance to αGal-expressing heart grafts following a lethal dose of irradiation. Here we show the first demonstration of permanent survival of αGal+ hearts following transplantation with autologous, lentivirus-transduced BM using a nonmyeloablative regimen. Autologous BM from GalT knockout (GalT–/–) mice was transduced with a lentiviral vector expressing porcine GalT and transplanted into sublethally irradiated (3 Gy) GalT–/– mice. Chimerism in the peripheral blood cells (PBCs) remained low but was higher in the BM, especially within the stromal cell population. Mice reconstituted with GalT did not produce anti-αGal Abs over time. We immunized these mice with αGal-expressing cells and assessed humoral immune responses. Anti-αGal xenoantibodies were not produced in mice reconstituted with GalT, but normal Ab responses to other xenoantigens were detected. Mice reconstituted with GalT accepted αGal+ heart grafts over 100 days. Transduction with lentiviral vectors results in chimerism at levels sufficient to induce long-term tolerance under nonmyeloablative conditions.

Specific humoral immune responses in 12 cases of food sensitization to sesame seed

1997 ◽  
Vol 27 (11) ◽  
pp. 1285-1291 ◽  
Author(s):  
M. N. KOLOPP-SARDA ◽  
D. A. MONERET-VAUTRIN ◽  
B. GOBERT ◽  
G. KANNY ◽  
M. BRODSCHII ◽  
...  
Keyword(s):  
Immune Responses ◽  
Sesame Seed ◽  
Humoral Immune ◽  
Humoral Immune Responses ◽  
Food Sensitization

Dominance of -specific IgG2 subclass in the humoral immune responses of naturally and experimentally infected cattle

1987 ◽  
Vol 15 (4) ◽  
pp. 311-322 ◽  
Author(s):  
N. Schmeer ◽  
K.L. Schnorr ◽  
J.A. Perez-Martinez ◽  
J. Storz
Keyword(s):  
Immune Responses ◽  
Infected Cattle ◽  
Humoral Immune ◽  
Humoral Immune Responses

scholarly journals Humoral immune responses to AAV gene therapy in the ocular compartment

2021 ◽  
Author(s):  
Michael Whitehead ◽  
Andrew Osborne ◽  
Patrick Yu‐Wai‐Man ◽  
Keith Martin
Keyword(s):  
Gene Therapy ◽  
Immune Responses ◽  
Humoral Immune ◽  
Humoral Immune Responses

scholarly journals Intersection of Sex and Frailty in Humoral Immune Responses to Influenza Vaccine in Community-Dwelling Older Adults

2020 ◽  
Vol 4 (Supplement_1) ◽  
pp. 271-272
Author(s):  
Janna Shapiro ◽  
Helen Kuo ◽  
Rosemary Morgan ◽  
Huifen Li ◽  
Sabra Klein ◽  
...  
Keyword(s):  
Older Adults ◽  
Immune Responses ◽  
Influenza A ◽  
Community Dwelling ◽  
Influenza Vaccines ◽  
Health Study ◽  
Cardiovascular Health Study ◽  
High Dose ◽  
Humoral Immune ◽  
Humoral Immune Responses

Abstract Older adults bear the highest burden of severe disease and complications associated with seasonal influenza, with annual vaccination serving as the best option for protection. Variability in vaccine efficacy exists, yet the host factors that affect immune responses to inactivated influenza vaccines (IIV) are incompletely understood. We hypothesized that sex and frailty interact to affect vaccine-induced humoral responses among older adults. To test this hypothesis, community-dwelling adults above 75 years of age were recruited yearly, assessed for frailty (as defined by the Cardiovascular Health Study criteria), and vaccinated with the high-dose trivalent IIV. Humoral immune responses were evaluated via hemagglutination inhibition titers. The study began during the 2014-2015 influenza season, with yearly cohorts ranging from 76-163 individuals. A total of 617 vaccinations were delivered from 2014-2019. In preliminary analyses, the outcome of interest was seroconversion, defined as ≥ 4-fold rise in titers. Crude odds ratios suggest that females are more likely to seroconvert to influenza A strains (H1N1: OR = 1.39, (0.98-1.96) ; H3N2: 1.17 (0.85 – 1.62)), while males are more likely to seroconvert to the B strain (OR = 0.85 (0.60 – 1.22)). Furthermore, this sex difference was modified by frailty – for example, the odds of seroconversion to H1N1 were 65% higher for females than males among those who were nonfrail, and only 30% higher among females who were frail. Together, these results suggest that sex and frailty interact to impact immune responses to influenza vaccines. These findings may be leveraged to better protect vulnerable populations.

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