Proteolytic specificity of chicken cathepsin L on bovine β-casein
Keyword(s):
Rp Hplc
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The proteolytic specificity of chicken cathepsin L was studied using bovine β-casein as substrate. The peptide mixtures obtained after various times of hydrolysis were separated by RP-HPLC and ten peptides were identified. Chicken cathepsin L accepts proline residues in all positions except P1′. Looking at the amino acid residues on the amino side of the scissile bond we found three times the Tyr-Pro pair at P1′–P2′ positions and that the S1′ subsite can interact with modified amino acids such as phosphoserine.
1993 ◽
Vol 62
(1)
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pp. 797-821
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1967 ◽
Vol 34
(1)
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pp. 85-88
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2019 ◽
Vol 24
(9)
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pp. 928-938
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2006 ◽
Vol 284
(6)
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pp. 575-585
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