Regulation of matrilysin expression in cells of squamous cell carcinoma by E-cadherin-mediated cell-cell contact

1997 ◽  
Vol 123 (1) ◽  
pp. 13-20 ◽  
Author(s):  
Alexander H. Borchers ◽  
Lisa A. Sanders ◽  
G. Tim Bowden
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cell Contact ◽  
In Cells ◽  
E Cadherin ◽  
Cell Cell

Expression of the cell-cell adhesion molecule E-cadherin in squamous cell carcinoma of the head and neck

2007 ◽  
Vol 18 (3) ◽  
pp. 196-201 ◽  
Author(s):  
GAYLE L. BOWIE ◽  
A.W. CASLIN ◽  
N.J. ROLAND ◽  
J.K.K. MA. FIELD ◽  
A.S. JONES ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Adhesion Molecule ◽  
Cell Adhesion Molecule ◽  
E Cadherin ◽  
Cell Cell

scholarly journals O218 E-CADHERIN EXPRESSION CORRELATES WITH PROGRESSION OF ESOPHAGEAL SQUAMOUS CELL CARCINOMA

2019 ◽  
Vol 32 (Supplement_2) ◽  
Author(s):  
Hanako Koda ◽  
Kazuhiko Yamada ◽  
Masayoshi Terayama ◽  
Sumiya Ryusuke ◽  
Kyoko Nohara ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Adhesion ◽  
Esophageal Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Immunohistochemical Staining ◽  
Clinicopathological Features ◽  
Normal Epithelium ◽  
E Cadherin ◽  
Cell Cell

Abstract Background & Aim E-cadherin is a member of the cadherin family and plays a major role in cell–cell adhesion of normal epithelium. Decreased or lack of E-cadherin expression has been reported in breast, colon and bladder cancer, and the disruption of the E-cadherin-mediated cell–cell adhesion is considered the first crucial step of metastasis. The esophageal stratified epithelial cells have many spines that intermingle with each other through desmosomes, in which E-cadherins play an important role for cell–cell adhesion. However, the significance of E-cadherin expression in the progression of esophageal squamous cell carcinoma (ESCC) still remains to be clarified. In the present study, we investigated the relation between E-cadherin expression in tumors and the clinicopathological features of ESCC. Method E-cadherin expression was evaluated in ESCC specimens of 61 patients who underwent surgery from April 2008 to December 2015 at the National Center for Global Health and Medicine by immunohistochemical staining. Distribution of E-cadherin in cancerous tissues was classified as Preserved (expression in cell membrane alone) or Disturbed (expression in cytoplasm or decreased/lack of expression of E-cadherin). Significance of the distribution pattern was analyzed by comparison to clinicopathological features. Results Thirty-seven of 61 (61%) cases revealed Preserved expression pattern while Disturbed distribution was observed in 24 of 61 (39%) cases. Compared to Preserved pattern, Disturbed expression of E-cadherin in tumors was significantly associated with advanced TNM stages (P=0.0462). Conclusion E-cadherin was expressed in most cases of ESCC; however, its distribution was not restricted in membrane but in the cytoplasm of tumors. Disturbed expression of E-cadherin in tumors correlated with advanced stage of ESCC, suggesting that the disruption of the E-cadherin-mediated cell–cell adhesion may play an important role in the progression of ESCC.

TPA-induced cell-cell contact formation and C-kinase activity in low Ca2+-grown squamous cell carcinoma cells

1990 ◽  
Vol 1 (2) ◽  
pp. 126
Author(s):  
Y. Kitajima ◽  
S. Inoue ◽  
H. Yaoita ◽  
S. Nagao ◽  
K. Nagata ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Kinase Activity ◽  
Carcinoma Cells ◽  
Cell Contact ◽  
Contact Formation ◽  
Cell Cell

Comparative E-Cadherin Digital Expression Analysis in HPV and non-HPV Related Squamous Cell Carcinoma of the Oral Cavity

2021 ◽  
Vol 41 (1) ◽  
pp. 163-167
Author(s):  
ARISTEIDIS CHRYSOVERGIS ◽  
VASILEIOS PAPANIKOLAOU ◽  
NICHOLAS MASTRONIKOLIS ◽  
DESPOINA SPYROPOULOU ◽  
MARIA ADAMOPOULOU ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Expression Analysis ◽  
Squamous Cell ◽  
Digital Expression ◽  
Digital Expression Analysis ◽  
E Cadherin

Reduced E-cadherin expression is associated with lymph node metastases in laryngeal squamous cell carcinoma

2012 ◽  
Vol 39 (2) ◽  
pp. 186-192 ◽  
Author(s):  
Jing-jia Li ◽  
Ge-hua Zhang ◽  
Xin-ming Yang ◽  
Shi-sheng Li ◽  
Xian Liu ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Lymph Node ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymph Node Metastases ◽  
Laryngeal Squamous Cell Carcinoma ◽  
Node Metastases ◽  
E Cadherin

scholarly journals EKSPRESI p53 DAN E-CADHERIN SEBAGAI PREDIKTOR PROGNOSIS PADA KARSINOMA SEL SKUAMOSA RONGGA MULUT DI RSUP DR. KARIADI SEMARANG

2019 ◽  
Vol 5 (1) ◽  
pp. 7-17
Author(s):  
Clara Pangaribuan
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
E Cadherin

p53 AND E-CADHERIN EXPRESSION AS  PREDICTORS OF PROGNOSTIC IN ORAL SQUAMOUS CELL CARCINOMA AT KARIADI HOSPITAL SEMARANG

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