Role of the kidney in hormone metabolism and its implications in clinical medicine

1980 ◽  
Vol 58 (19) ◽  
pp. 1005-1012 ◽  
Author(s):  
D. S. Emmanouel ◽  
M. D. Lindheimer ◽  
A. I. Katz
1971 ◽  
Vol 68 (1_Suppl) ◽  
pp. S279-S294 ◽  
Author(s):  
Paul Robel

ABSTRACT Of the information available on steroid hormone metabolism in responsive tissues, only that relating hormone metabolism to physiological activity is reviewed, i. e. metabolite activity in isolated in vitro systems, binding of metabolites to target tissue receptors, specific steroid hormone metabolizing enzymes and relationship of hormone metabolism to target organ physiological state. Further, evidence is presented in the androgen field, demonstrating 5α-reduced metabolites, formed inside the target cells, as active compounds. This has led to a consideration of testosterone as a »prehormone«. The possibility that similar events take place in tissues responding to progesterone is discussed. Finally, the role of hormone metabolism in the regulation of hormone availability and/or renewal in target cells is discussed. In this context, reference is made to the potential role of plasma binding proteins and cytosol receptors.


1987 ◽  
Vol 16 (4) ◽  
pp. 221-227 ◽  
Author(s):  
N Messenger ◽  
P Bowker

This paper reports the results of a survey carried out to assess the clinical usage currently being made of gait analysis facilities within the UK. Thirty-five centres were circulated with a questionnaire which requested information under four main headings: (i) equipment, (ii) research projects, (iii) clinical service commitments, and (iv) subjective views of the ultimate clinical value of the service. Of the 25 completed questionnaires returned, 16 were suitable for inclusion in the final analysis of data. The survey provided useful data on the equipment and facilities available in each centre together with details of the service available to prospective referring clinicians. Ten centres were considered as being currently involved in some clinical work, with six of these being routinely involved. The respondents generally felt that gait analysis techniques have a clinical context, if not yet routinely, but the numbers of referrals to the centres is still quite small. A number of areas worthy of further work were identified by the respondents. It is hoped that presentation of these results will stimulate dialogue between centres and between clinicians and bioengineers.


2019 ◽  
Vol 26 ◽  
pp. 7-19
Author(s):  
Ryszard W. Gryglewski

Medicine in terms of Jędrzej Śniadecki Jędrzej Śniadecki (1768–1838) remains one of most eminent scholars of his times. Remembered as a founder of modern chemistry in Poland, one of early pioneers in anthropology and social sciences, and author of the two volume book Theory of organic being (Teoria jestestw organicznych), in which the modern metabolic concept of life processes can be considered as grounded; he was also a highly educated and gifted physician. This paper aims to show the importance of medicine in Śniadecki’s theory of life, in its physiological and pathological manifestations in regard to the clinical model and the medical practice which he followed. It deals with the concept of illness as described in Śniadecki’s writings, focusing on the role of irritation and organic reaction as the major components of his proposed pathological model. The dynamic and variable conditions of diseases are explained by means of metabolic changes, which was a truly pioneering concept, already described in Śniadecki’s earlier theoretical works on the subject of life and nature. The paper discusses the problem of influence in terms of the leading medical doctrines at the end of the 18th and the beginning of the 19th century, namely those of John Brown (1735–1788) and François Broussais (1772–1838), on Śniadecki as a researcher and practitioner. For practical (clinical) medicine his reserve towards auscultation and percussion, then a slowly gaining field in clinical subjects, is clearly present in Śniadecki’s writings and teaching. His passive and, as far as we can tell, sceptical attitude is explained by the lack of convincing evidence, based on empirical and experimental data, which would enable to connect the physical signs of a diagnosis fulfilled by means of stethoscope to that of the percussion process. It must be remembered that the books by Adam Raciborski (1809–1871) and Joseph Škoda (1805–1881) were both published in the 1830s, where modern diagnosing methods were established using a suitable scientific background to explain their importance. This was too late to influence the clinical work of Śniadecki. The same scepticism, with an obvious demand for strict and experimentally derived data, is probably responsible for the conservative therapy present in Śniadecki’s teaching.


2021 ◽  
pp. 113-118

Nesfatin-1is first described in 2006 as an anorectic peptide and regulate food intake. In following years, the studies demonstrated the presence of nesfatin-1 in central and various peripheral tissues. Thus, nesfatin-1 popularity increasing widely in clinical medicine, especially in cardiology, neurology, reproduction, metabolic disorders, psychiatric disorders, gastrointestinal system. Today, the main point concerning nesfatin-1 action in body organ and systems is concentrate its biological signals effects. Thus the increasing knowledge in these area will be highlighted for future studies especially in serious health problem all over the world population.


1999 ◽  
Vol 276 (2) ◽  
pp. R357-R362 ◽  
Author(s):  
Tom van der Poll ◽  
Erik Endert ◽  
Susette M. Coyle ◽  
Jan M. Agosti ◽  
Stephen F. Lowry

To determine the role of tumor necrosis factor (TNF) in endotoxin-induced changes in plasma thyroid hormone and thyroid-stimulating hormone (TSH) concentrations, 24 healthy postabsorptive humans were studied on a control study day ( n= 6), after infusion of a recombinant TNF receptor IgG fusion protein (TNFR:Fc; 6 mg/m2; n = 6) after intravenous injection of endotoxin (2 ng/kg; n = 6), or after administration of endotoxin with TNFR:Fc ( n = 6). Administration of TNFR:Fc alone did not affect thyroid hormone or TSH levels when compared with the control day. Endotoxin induced a transient rise in plasma TNF activity (1.5 h: 219 ± 42 pg/ml), which was completely prevented by TNFR:Fc ( P < 0.05). After endotoxin administration, plasmal-thyroxine (T4), free T4, 3,5,3′-triiodothyronine (T3), and TSH were lower and 3,3′,5′-triiodothyronine was higher than on the control day (all P < 0.05). Coinfusion of TNFR:Fc with endotoxin did not influence these endotoxin-induced changes. Our results suggest that endogenous TNF does not play an important role in the alterations in plasma thyroid hormone and TSH concentrations induced by mild endotoxemia in healthy humans.


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