Liver structure and function during long-term treatment with cyproterone acetate

1987 ◽  
Vol 240 (4) ◽  
pp. 217-223 ◽  
Author(s):  
E. Kaiser ◽  
H. S. Gruner
Keyword(s):  
Cyproterone Acetate ◽  
Term Treatment ◽  
Structure And Function ◽  
Long Term Treatment ◽  
Liver Structure ◽  
And Function

Changes in Liver Structure and Function after Short-Term and Long-Term Treatment of Rats with Dehydroepiandrosterone

1992 ◽  
Vol 122 (4) ◽  
pp. 967-976 ◽  
Author(s):  
Monica Bellei ◽  
Daniela Battelli ◽  
Claudio Fornieri ◽  
Giuseppe Mori ◽  
Umberto Muscatello ◽  
...  
Keyword(s):  
Term Treatment ◽  
Structure And Function ◽  
Short Term ◽  
Long Term Treatment ◽  
Liver Structure ◽  
And Function

scholarly journals Brain structure of perinatally HIV-infected patients on long-term treatment

2019 ◽  
Vol 9 (5) ◽  
pp. 433-442 ◽  
Author(s):  
Malon Van den Hof ◽  
Anne Marleen ter Haar ◽  
Matthan W.A. Caan ◽  
Rene Spijker ◽  
Johanna H. van der Lee ◽  
...  
Keyword(s):  
Brain Structure ◽  
Diffusion Tensor ◽  
Structure And Function ◽  
Resonance Spectroscopy ◽  
Cross Sectional ◽  
Long Term Treatment ◽  
Brain Structure And Function ◽  
And Function ◽  
Hiv Negative

ObjectiveWe aim to give an overview of the available evidence on brain structure and function in PHIV-infected patients (PHIV+) using long-term combination antiretroviral therapy (cART) and how differences change over time.MethodsWe conducted an electronic search using MEDLINE, Embase, and PsycINFO. We used the following selection criteria: cohort and cross-sectional studies that reported on brain imaging differences between PHIV+ of all ages who used cART for at least six months before neuroimaging and HIV-negative controls. Two reviewers independently selected studies, performed data extraction, and assessed quality of studies.ResultsAfter screening 1500 abstracts and 343 full-text articles, we identified 19 eligible articles. All included studies had a cross-sectional design and used MRI with different modalities: structural MRI (n = 7), diffusion tensor imaging (DTI) (n = 6), magnetic resonance spectroscopy (n = 5), arterial spin labeling (n = 1), and resting-state functional neuroimaging (n = 1). Studies showed considerable methodological limitations and heterogeneity, preventing us to perform meta-analyses. DTI data on white matter microstructure suggested poorer directional diffusion in cART-treated PHIV+ compared with controls. Other modalities were inconclusive.ConclusionEvidence may suggest brain structure and function differences in the population of PHIV+ on long-term cART compared with the HIV-negative population. Because of a small study population, and considerable heterogeneity and methodological limitations, the extent of brain structure and function differences on neuroimaging between groups remains unknown.

Biocompatibility of Charcoal Hemoperfusion. Effects of Long-Term Treatment on Lymphocyte Characteristics and Function

1986 ◽  
Vol 9 (5) ◽  
pp. 301-304 ◽  
Author(s):  
S. Stefoni ◽  
A. Nanni Costa ◽  
G. Liviano D'Arcangelo ◽  
M. Biavati ◽  
S. lannelli ◽  
...  
Keyword(s):  
Antigen Expression ◽  
Term Treatment ◽  
T Cell Subsets ◽  
Long Term Treatment ◽  
Circulating Lymphocytes ◽  
And Function ◽  
Charcoal Hemoperfusion

Biocompatibility of charcoal hemoperfusion was studied in a group of 15 uremic patients, evaluating the effects of long-term treatment on some structural and functional parameters of circulating lymphocytes: in vivo distribution of T-cell subsets; surface T3, T4 and T8 antigen expression, in vivo and in vitro DNA synthesis. A comparative analysis was performed with patients on conventional dialysis using cuprophan membranes.

Intact endothelial and smooth muscle function in small resistance arteries after 48 h in vessel culture

2000 ◽  
Vol 279 (3) ◽  
pp. H1434-H1439 ◽  
Author(s):  
Steffen-Sebastian Bolz ◽  
Susanne Pieperhoff ◽  
Cor De Wit ◽  
Ulrich Pohl
Keyword(s):  
Smooth Muscle ◽  
Vascular Function ◽  
Calf Serum ◽  
Term Treatment ◽  
Resistance Arteries ◽  
Response Curves ◽  
Vascular Integrity ◽  
Long Term Treatment ◽  
And Function

Long-term culture of resistance vessels allows introduction of molecular biology techniques for use in microvascular research. The aim of the present study was to establish a culture protocol that preserved vascular integrity and function in microvessels for 48 h in culture. Skeletal muscle resistance arteries were excised from the hamster gracilis muscle. Segments were assigned to immediate functional tests or to vessel culture, during which segments were perfused and superfused at a transmural pressure of 45 mmHg with Leibovitz (L15) medium containing 15% fetal calf serum and antibiotics for 48 h. Cultured and freshly isolated vessels showed similar levels of spontaneous tone, myogenic responses, changes in smooth muscle intracellular calcium (Cai 2+) (fura 2), and vascular diameter (video microscopy) in response to 0.3 M norepinephrine and similar concentration-response curves for acetylcholine (endothelium dependent, ± N ω-nitro-l-arginine) and sodium nitroprusside (endothelium independent). Measurements of endothelial Cai 2+ revealed similar acetylcholine-induced increases in endothelial Cai 2+ in both groups. It is concluded that vascular function can be preserved while maintaining vessels in culture. Thus it is possible to utilize protocols that require long-term treatment.

Increase in circulating CD4+CD25+Foxp3+ T cells in patients with Philadelphia-negative chronic myeloproliferative neoplasms during treatment with IFN-α

Blood ◽  
2011 ◽  
Vol 118 (8) ◽  
pp. 2170-2173 ◽  
Author(s):  
Caroline Hasselbalch Riley ◽  
Morten Krogh Jensen ◽  
Marie Klinge Brimnes ◽  
Hans Carl Hasselbalch ◽  
Ole Weis Bjerrum ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Myeloproliferative Neoplasms ◽  
Term Treatment ◽  
Immune Reactivity ◽  
Chronic Myeloproliferative Neoplasms ◽  
Healthy Donors ◽  
Long Term Treatment ◽  
And Function

Abstract Recent reports have described complete or major molecular remission in patients with polycythemia vera after long-term treatment with the immunomodulatory agent IFN-α2. Accordingly, there are reasons to believe that the immune system is a key player in eradicating the JAK2 mutated clone in these patients. Foxp3+ regulatory T cells play a pivotal role in maintaining immune homeostasis and, importantly, preventing immune reactivity to self-antigens; however, their suppressive activity can compromise an effective antitumor immune response, and high frequencies of regulatory T cells in peripheral blood have been reported in both hematologic and solid cancers. We have analyzed the number, phenotype, and function of circulating CD4+CD25+Foxp3+ T cells in patients with chronic myeloproliferative neoplasms. Surprisingly, we found a marked expansion of this subset of lymphocytes in patients treated with IFN-α2 (13.0%; 95% confidence interval [CI] 10.8% to 15.2%) compared with healthy donors (6.1%; 95% CI 4.9% to 7.2%), patients with untreated chronic myeloproliferative neoplasms (6.9%; 95% CI 5.8% to 7.4%), or patients treated with hydroxyurea (5.8%; 95% CI 4.3% to 7.4%; P < .0001).

scholarly journals Long-Term Treatment with Empagliflozin Attenuates Renal Damage in Obese Zucker Rat

2019 ◽  
Vol 128 (08) ◽  
pp. 512-519 ◽  
Author(s):  
Nandini D. P. K. Manne ◽  
Gautam Kumar Ginjupalli ◽  
Kevin M. Rice ◽  
Ravikumar Arvapalli ◽  
Vincent A. Graffeo ◽  
...  
Keyword(s):  
Glucose Tolerance ◽  
Structure And Function ◽  
Zucker Rats ◽  
Renal Tubules ◽  
Therapeutic Benefits ◽  
Renal Structure ◽  
Long Term Treatment ◽  
Obese Zucker Rats ◽  
And Function

Abstract Introduction Empagliflozin, a known inhibitor of sodium-glucose cotransporter type 2 (SGLT2) decreases glucose reabsorption by the renal tubules and promotes glucose excretion into the urine. While the effectiveness of Empagliflozin in the management of hyperglycemia along with associated cardiovascular and all-cause mortality has been demonstrated previously, the therapeutic benefits associated with the long-term use of this drug in obese animals have yet to be investigated. Methods Male 5-week-old lean and obese Zucker rats were randomly assigned to one of the 4 groups- lean control, lean treated, obese control, obese treated and treated with either Empagliflozin (10 mg/kg BW / day) or placebo for 25 weeks to investigate the therapeutic effect of Empagliflozin. Results Empagliflozin treatment in the obese animals was associated with decreased body weight, attenuated the loss of F-actin from the renal tubules and improved renal structure and function. These changes in renal function were associated with significant improvements in the glucose tolerance, and decreased non-fasting circulatory levels of glucose, amylase, and other inflammatory markers including NGAL, cystatin C, and clusterin. Conclusion Long-term use of Empagliflozin in diabetic obese Zucker rats is associated with improvements in glucose tolerance and decreased loss of renal structure and function.

Long-term treatment of familial male-limited precocious puberty (testotoxicosis) with cyproterone acetate or ketoconazole

2008 ◽  
Vol 69 (1) ◽  
pp. 93-98 ◽  
Author(s):  
Madson Queiroz Almeida ◽  
Vinicius Nahime Brito ◽  
Thereza Selma S. Lins ◽  
Gil Guerra-Junior ◽  
Margaret de Castro ◽  
...  
Keyword(s):  
Precocious Puberty ◽  
Cyproterone Acetate ◽  
Term Treatment ◽  
Long Term Treatment
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