Role of GABAA and GABAB receptors of the brain in the negative feedback mechanism of the hypothalamohypophyseotesticular complex

1996 ◽  
Vol 26 (3) ◽  
pp. 277-280 ◽  
Author(s):  
E. V. Naumenko ◽  
A. V. Amikishieva ◽  
L. I. Serova
Keyword(s):  
Negative Feedback ◽  
Feedback Mechanism ◽  
Gabab Receptors ◽  
Negative Feedback Mechanism ◽  
Gabaa And Gabab Receptors ◽  
The Brain

scholarly journals Role of GABA-A and GABA-B receptors of the brain in the hypothalamo-pituitary-testicular regulation by the negative feedback mechanism

1995 ◽  
Vol 41 (4) ◽  
pp. 36-38
Author(s):  
Ye. V. V. Naumenko ◽  
A. V. Amikishiyeva ◽  
L. I. Serova
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Negative Feedback ◽  
Feedback Mechanism ◽  
Gaba A ◽  
Negative Feedback Mechanism ◽  
The Central Nervous System ◽  
The Brain ◽  
Stimulation Of

The role of gamma-aminobutyric acid (GABA) of the brain and its receptors in the hypothalamo-pituitary-testicular (HPT) regulation by the negative feedback mechanism was for the first time studied in sham-operated and unilaterally castrated adult Wister rats. Increased level of GABA in the central nervous system following an injection of GABA transaminase inhibitor, aminoacetic acid, into the lateral ventricle of the brain was associated with activation of a compensatory increase of testosterone level in the blood, caused by unilateral castration. GABA effect is mediated through the receptors. Muscimol stimulation of GABA-A receptors of the central nervous system activated and their blocking with bicucullin inhibited a compensatory increase of testosterone level in the blood caused by hemicastration. Baclofen stimulation of cerebral GABA-B receptors was associated with an inhibition and their saclofen blocking with stimulation of the level of male sex steroid hormone in the blood following unilateral castration. A conclusion is made about participation of GABAergic mechanisms of the brain in the regulation of HPT function via the negative feedback mechanism

scholarly journals Studies on the Physiological Role of Hypothalamic TRH on the Negative Feedback Mechanism of the Pituitary-Thyroid Axis

1979 ◽  
Vol 55 (6) ◽  
pp. 776-786
Author(s):  
Masatomo MORI ◽  
Kihachi OHSHIMA ◽  
Sakae MARUTA ◽  
Hitoshi FUKUDA ◽  
Yohnosuke SHIMOMURA ◽  
...  
Keyword(s):  
Negative Feedback ◽  
Physiological Role ◽  
Feedback Mechanism ◽  
Negative Feedback Mechanism ◽  
Pituitary Thyroid Axis ◽  
Thyroid Axis

scholarly journals A negative feedback mechanism in the insulin-regulated glucose homeostasis in Japanese flounder Paralichthys olivaceus by two ways of glucose administration

2017 ◽  
Author(s):  
Dong Liu ◽  
Dongdong Han ◽  
Benyue Guo ◽  
Kangyu Deng ◽  
Zhixiang Gu ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Glucose Homeostasis ◽  
Negative Feedback ◽  
Serum Insulin ◽  
Feedback Mechanism ◽  
Japanese Flounder ◽  
Gut Peptides ◽  
Gene Expressions ◽  
Negative Feedback Mechanism ◽  
The Brain

AbstractThe present study comparatively analyzed the blood glucose and insulin concentration, the temporal and spatial expression of brain-gut peptides and the key enzymes of glycolysis and gluconeogenesis in Japanese flounder by intraperitoneal (IP) injection and oral (OR) administration of glucose. Samples were collected at 0, 1, 3, 5, 7, 9, 12, 24 and 48h after IP and OR, respectively. Results showed that the hyperglycemia lasted 5 hours and 21 hours in OR and IP group, respectively. The serum insulin concentration significantly decreased (1.58±0.21mIU/L) at 3h after IP glucose. However, it significantly increased at 3h (3.37±0.34mIU/L) after OR glucose. The gene expressions of prosomatostatin, neuropeptide Y, cholecystokinin precursor and orexin precursor in the brain showed different profiles between the OR and IP group. The OR not IP administration of glucose had significant effects on the gene expressions of preprovasoactive intestinal peptide, pituitary adenylate cyclase activating polypeptide and gastrin in the intestine. When the blood glucose concentration peaked in both IP and OR group, the glucokinase expression in liver was stimulated, but the expression of fructose-1,6-bisphosphatase was depressed. In conclusion, brain-gut peptides were confirmed in the present study. And the serum insulin and the brain-gut peptides have different responses between the IP and OR administration of glucose. A negative feedback mechanism in the insulin-regulated glucose homeostasis was suggested in Japanese flounder. Furthermore, this regulation could be conducted by activating PI3k-Akt, and then lead to the pathway downstream changes in glycolysis and gluconeogenesis.

scholarly journals Induction of IκBα mRNA Expression in the Brain by Glucocorticoids: A Negative Feedback Mechanism for Immune-to-Brain Signaling

2000 ◽  
Vol 20 (17) ◽  
pp. 6473-6477 ◽  
Author(s):  
Ning Quan ◽  
Lingli He ◽  
Wenmin Lai ◽  
Tiansheng Shen ◽  
Miles Herkenham
Keyword(s):  
Mrna Expression ◽  
Negative Feedback ◽  
Feedback Mechanism ◽  
Negative Feedback Mechanism ◽  
The Brain

scholarly journals Evolution of the repression mechanisms in circadian clocks

2022 ◽  
Vol 23 (1) ◽  
Author(s):  
Jonathan Tyler ◽  
Yining Lu ◽  
Jay Dunlap ◽  
Daniel B. Forger
Keyword(s):  
Mathematical Modeling ◽  
Mathematical Model ◽  
Negative Feedback ◽  
Systems Analysis ◽  
Feedback Mechanism ◽  
Circadian Clocks ◽  
Negative Feedback Mechanism ◽  
Wide Range ◽  
Recent Experimental Work

Abstract Background Circadian (daily) timekeeping is essential to the survival of many organisms. An integral part of all circadian timekeeping systems is negative feedback between an activator and repressor. However, the role of this feedback varies widely between lower and higher organisms. Results Here, we study repression mechanisms in the cyanobacterial and eukaryotic clocks through mathematical modeling and systems analysis. We find a common mathematical model that describes the mechanism by which organisms generate rhythms; however, transcription’s role in this has diverged. In cyanobacteria, protein sequestration and phosphorylation generate and regulate rhythms while transcription regulation keeps proteins in proper stoichiometric balance. Based on recent experimental work, we propose a repressor phospholock mechanism that models the negative feedback through transcription in clocks of higher organisms. Interestingly, this model, when coupled with activator phosphorylation, allows for oscillations over a wide range of protein stoichiometries, thereby reconciling the negative feedback mechanism in Neurospora with that in mammals and cyanobacteria. Conclusions Taken together, these results paint a picture of how circadian timekeeping may have evolved.

Activation of the Na+/K+-ATPase by insulin and glucose as a putative negative feedback mechanism in pancreatic beta-cells

2008 ◽  
Vol 457 (6) ◽  
pp. 1351-1360 ◽  
Author(s):  
M. Düfer ◽  
D. Haspel ◽  
P. Krippeit-Drews ◽  
L. Aguilar-Bryan ◽  
J. Bryan ◽  
...  
Keyword(s):  
Beta Cells ◽  
Negative Feedback ◽  
Pancreatic Beta Cells ◽  
Feedback Mechanism ◽  
Negative Feedback Mechanism

scholarly journals Negative feedback in ants: crowding results in less trail pheromone deposition

2013 ◽  
Vol 10 (81) ◽  
pp. 20121009 ◽  
Author(s):  
Tomer J. Czaczkes ◽  
Christoph Grüter ◽  
Francis L. W. Ratnieks
Keyword(s):  
Negative Feedback ◽  
Trail Pheromone ◽  
Distribution Networks ◽  
Feedback Mechanism ◽  
Lasius Niger ◽  
Feedback Signal ◽  
Control Mechanisms ◽  
Negative Feedback Mechanism ◽  
Self Organized ◽  
Fold Reduction

Crowding in human transport networks reduces efficiency. Efficiency can be increased by appropriate control mechanisms, which are often imposed externally. Ant colonies also have distribution networks to feeding sites outside the nest and can experience crowding. However, ants do not have external controllers or leaders. Here, we report a self-organized negative feedback mechanism, based on local information, which downregulates the production of recruitment signals in crowded parts of a network by Lasius niger ants. We controlled crowding by manipulating trail width and the number of ants on a trail, and observed a 5.6-fold reduction in the number of ants depositing trail pheromone from least to most crowded conditions. We also simulated crowding by placing glass beads covered in nest-mate cuticular hydrocarbons on the trail. After 10 bead encounters over 20 cm, forager ants were 45 per cent less likely to deposit pheromone. The mechanism of negative feedback reported here is unusual in that it acts by downregulating the production of a positive feedback signal, rather than by direct inhibition or the production of an inhibitory signal.

#114 Immunomodulatory effects of Met-enkephalin and its derivatives on cytokine expression: A possible negative feedback mechanism

2005 ◽  
Vol 19 (4) ◽  
pp. e59
Author(s):  
M. Piva ◽  
J.I. Moreno ◽  
F.S. Jenkins ◽  
J.K.A. Smith ◽  
J.L. Thomas ◽  
...  
Keyword(s):  
Negative Feedback ◽  
Feedback Mechanism ◽  
Cytokine Expression ◽  
Immunomodulatory Effects ◽  
Negative Feedback Mechanism
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