Replacement therapy with nitric oxide or nitric oxide dornor in vivo, maintains the bone mass in rats after ovariectomy

1996 ◽  
Vol 6 (S1) ◽  
pp. 272-272
Author(s):  
S. J. Wimalawansa ◽  
P. R. Gangula ◽  
G. De Marco ◽  
C. Yallampalli
Keyword(s):  
Nitric Oxide ◽  
Bone Mass ◽  
Replacement Therapy

Effect of nitric oxide synthase inhibitors on bone metabolism in growing rats

1996 ◽  
Vol 270 (5) ◽  
pp. E840-E845 ◽  
Author(s):  
H. Tsukahara ◽  
M. Miura ◽  
S. Tsuchida ◽  
I. Hata ◽  
K. Hata ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Bone Mass ◽  
Bone Mineral ◽  
Normal Serum ◽  
Bone Mineral Status ◽  
Growing Rats ◽  
Bone Mineral Mass ◽  
Bone Degradation ◽  
Cross Links

We examined the effects of chronic nitric oxide (NO) blockade on bone mineral status in growing rats. Oral administration of NG-nitro-L-arginine methyl ester (L-NAME) for 4 wk caused hypertension and a significant reduction in urinary NO2- and NO3- excretion. Four-week oral aminoguanidine (AG, 400 mg/dl of drinking water) did not alter blood pressure but caused a significant decrease in urinary NO2- and NO3-. Rats treated with L-NAME at doses of 20 and 50 mg/dl had normal bone mineral mass in the lumbar spine, but the highest dose (80 mg/dl) caused a slight decrease in bone mass. Chronic AG induced a significant spine osteopenia. This effect of AG was abolished by the simultaneous administration of L-arginine (2.0 g/dl). AG-induced osteopenia was associated with a significant increase in urine excretion of collagen cross-links with normal serum osteocalcin. These findings indicate that chronic AG administration can cause an imbalance between bone resorption and formation, resulting in a decrease in bone mass in growing rats, and suggest that NO produced by inducible NO synthase plays an important role in basal osteoclast bone degradation activity in vivo.

»In Vivo« Platelet Aggregates after Replacement Therapy in Patients with Hemophilia A

1979 ◽  
Vol 42 (02) ◽  
pp. 813-814 ◽  
Author(s):  
Guido Grignani ◽  
Gabriella Gamba ◽  
Edoardo Ascari
Keyword(s):  
Replacement Therapy ◽  
Hemophilia A ◽  
Platelet Aggregates

Nitric Oxide Is Responsible for Flow-Dependent Dilatation of Human Peripheral Conduit Arteries In Vivo

Circulation ◽  
1995 ◽  
Vol 91 (5) ◽  
pp. 1314-1319 ◽  
Author(s):  
Robinson Joannides ◽  
Walter E. Haefeli ◽  
Lilly Linder ◽  
Vincent Richard ◽  
El Hassan Bakkali ◽  
...  
Keyword(s):  
Nitric Oxide

In Vivo Spin Trapping of Glyceryl Trinitrate–Derived Nitric Oxide in Rabbit Blood Vessels and Organs

Circulation ◽  
1995 ◽  
Vol 92 (7) ◽  
pp. 1876-1882 ◽  
Author(s):  
Alexander Mülsch ◽  
Peter Mordvintcev ◽  
Eberhard Bassenge ◽  
Frank Jung ◽  
Bernd Clement ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Glyceryl Trinitrate ◽  
Blood Vessels ◽  
Spin Trapping ◽  
Rabbit Blood

Vasculoprotective Role of Inducible Nitric Oxide Synthase at Inflammatory Coronary Lesions Induced by Chronic Treatment With Interleukin-1β in Pigs in Vivo

Circulation ◽  
1997 ◽  
Vol 96 (9) ◽  
pp. 3104-3111 ◽  
Author(s):  
Yoshihiro Fukumoto ◽  
Hiroaki Shimokawa ◽  
Toshiyuki Kozai ◽  
Toshiaki Kadokami ◽  
Kouichi Kuwata ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Chronic Treatment ◽  
Interleukin 1Β ◽  
Coronary Lesions ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide
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