Effects of high fat diets on the activity of palmitoyl-CoA hydrolase in rat liver

Lipids ◽  
1985 ◽  
Vol 20 (1) ◽  
pp. 49-52 ◽  
Author(s):  
Rolf K. Berge ◽  
Magny S. Thomassen
Keyword(s):  
Rat Liver ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets ◽  
Coa Hydrolase

Effect of various n − 3/n − 6 fatty acid ratio contents of high fat diets on rat liver and heart peroxisomal and mitochondrial β-oxidation

1993 ◽  
Vol 1170 (2) ◽  
pp. 151-156 ◽  
Author(s):  
Joseph Vamecq ◽  
Louis Vallee ◽  
Paulette Lechêne de la Porte ◽  
Monique Fontaine ◽  
Dirk de Craemer ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Rat Liver ◽  
Fatty Acid Ratio ◽  
High Fat ◽  
Acid Ratio ◽  
High Fat Diets ◽  
Fat Diets

The effect of high-fat diets on microsomal lauric acid hydroxylation in rat liver

1986 ◽  
Vol 879 (2) ◽  
pp. 209-214 ◽  
Author(s):  
Astrid Nilsson ◽  
Hibret Arey ◽  
Jan I. Pedersen ◽  
Erling N. Christiansen
Keyword(s):  
Rat Liver ◽  
Lauric Acid ◽  
High Fat ◽  
High Fat Diets ◽  
Acid Hydroxylation ◽  
Fat Diets

scholarly journals Effects of high-fat diets on hepatic fatty acid oxidation in the rat Isolation of rat liver peroxisomes by vertical-rotor centrifugation by using a self-generated, iso-osmotic, Percoll gradient

1981 ◽  
Vol 196 (1) ◽  
pp. 149-159 ◽  
Author(s):  
C E Neat ◽  
M S Thomassen ◽  
H Osmundsen
Keyword(s):  
Fatty Acids ◽  
Fatty Acid ◽  
Rat Liver ◽  
Unsaturated Fatty Acids ◽  
High Fat ◽  
Beta Oxidation ◽  
Vertical Rotor ◽  
High Fat Diets ◽  
Fat Diets ◽  
Long Chain

1. Rat liver peroxisomal fractions were isolated in iso-osmotic Percoll gradients by using vertical-rotor centrifugation. The fractions obtained with rats given various dietary treatments were characterized. 2. The effect on peroxisomal beta-oxidation of feeding 15% by wt. of dietary fat for 3 weeks was investigated. High-fat diets caused induction of peroxisomal beta-oxidation, but diets rich in very-long-chain mono-unsaturated fatty acids produced a more marked induction. 3. Peroxisomal beta-oxidation induced by diets rich in very-long-chain mono-unsaturated fatty acids can oxidize such acids. Trans-isomers of mono-unsaturated fatty acids are oxidized at rates that are faster than, or similar to, those obtained with corresponding cis-isomers. 4. Rates of oxidation of [14-14C]erucic acid by isolated rat hepatocytes isolated from rats fed on high-fat diets increased with the time on those diets in a fashion very similar to that previously reported for peroxisomal beta-oxidation [see Neat, Thomassen & Osmundsen (1980) Biochem, J. 186, 369-371]. 5. Total liver capacities for peroxisomal beta-oxidation (expressed as acetyl groups produced per min) were estimated to range from 10 to 30% of mitochondrial capacities, depending on dietary treatment and fatty acid substrate. A role is proposed for peroxisomal beta-oxidation in relation to the metabolism of fatty acids that are poorly oxidized by mitochondrial beta-oxidation, and, in general, as regards oxidation of fatty acids during periods of sustained high hepatic influx of fatty acids.

scholarly journals High-fat diets affect the expression of nuclear retinoic acid receptor in rat liver

2000 ◽  
Vol 83 (6) ◽  
pp. 665-671 ◽  
Author(s):  
S. Bonilla ◽  
A. Redonnet ◽  
C. Noël-Suberville ◽  
V. Pallet ◽  
H. Garcin ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Retinoic Acid ◽  
Rat Liver ◽  
Vegetable Oil ◽  
Retinoic Acid Receptor ◽  
High Fat ◽  
Acid Receptor ◽  
Significant Difference ◽  
High Fat Diets ◽  
Fat Diets

The purpose of this study was to differentiate between the effects of the amount and the type of dietary lipids on the expression of the retinoic acid receptor (RAR), but also the peroxisome proliferator-activated receptor (PPAR) and the receptor of the 9-cis retinoic acid (retinoid X receptor (RXR)) in rat liver. Six groups of eight rats (5-weeks old) were fed during 4 weeks on the following diets: control 50 g vegetable oil/kg, high-fat diet 250 g vegetable oil/kg. These oils were either coconut oil (rich in saturated fatty acids) or olive oil (rich in monounsaturated fatty acids) or safflower oil (rich in polyunsaturated fatty acids, mainly as n-6). The three high-fat diets induced a significant decrease of the maximal binding capacity of RAR and of the abundance of RARβ mRNA. Simultaneously, an increased expression of PPARα mRNA was observed while no significant difference on abundance of RXRα mRNA was observed. The mechanisms involved are probably multiple, but one hypothesis is that a modification of the equilibrium between the nuclear receptors, resulting from an increased expression of PPAR, induces a decreased expression of RAR in rat liver.

High-Fat Diets and LXRs Expression in Rat Liver and Hypothalamus

2019 ◽  
Vol 39 (7) ◽  
pp. 963-974 ◽  
Author(s):  
Mariana Rey ◽  
María Sol Kruse ◽  
Rocío Nahimé Magrini-Huamán ◽  
Héctor Coirini
Keyword(s):  
Rat Liver ◽  
High Fat ◽  
High Fat Diets ◽  
Fat Diets

scholarly journals Effects of low-stearate palm oil and high-stearate lard high-fat diets on rat liver lipid metabolism and glucose tolerance

2015 ◽  
Vol 12 (1) ◽  
Author(s):  
Sharon Janssens ◽  
Mattijs M. Heemskerk ◽  
Sjoerd A. van den Berg ◽  
Natal A. van Riel ◽  
Klaas Nicolay ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Glucose Tolerance ◽  
Rat Liver ◽  
Palm Oil ◽  
Liver Lipid ◽  
High Fat ◽  
High Fat Diets ◽  
Liver Lipid Metabolism ◽  
Fat Diets

Non-Fasting Factor VII Coagulant Activity (FVII:C) Increased by High-Fat Diet

1994 ◽  
Vol 71 (06) ◽  
pp. 755-758 ◽  
Author(s):  
E M Bladbjerg ◽  
P Marckmann ◽  
B Sandström ◽  
J Jespersen
Keyword(s):  
High Fat Diet ◽  
Fat Content ◽  
Factor Vii ◽  
Amidolytic Activity ◽  
High Fat ◽  
Low Fat Diet ◽  
Increased Risk ◽  
Coagulant Activity ◽  
High Fat Diets ◽  
Fat Diets

SummaryPreliminary observations have suggested that non-fasting factor VII coagulant activity (FVII:C) may be related to the dietary fat content. To confirm this, we performed a randomised cross-over study. Seventeen young volunteers were served 2 controlled isoenergetic diets differing in fat content (20% or 50% of energy). The 2 diets were served on 2 consecutive days. Blood samples were collected at 8.00 h, 16.30 h and 19.30 h, and analysed for triglycerides, FVII coagulant activity using human (FVII:C) or bovine thromboplastin (FVII:Bt), and FVII amidolytic activity (FVIPAm). The ratio FVII:Bt/FVII:Am (a measure of FVII activation) increased from fasting levels on both diets, but most markedly on the high-fat diet. In contrast, FVII: Am (a measure of FVII protein) tended to decrease from fasting levels on both diets. FVII:C rose from fasting levels on the high-fat diet, but not on the low-fat diet. The findings suggest that high-fat diets increase non-fasting FVII:C, and consequently may be associated with increased risk of thrombosis.

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