Tryptophan content in serum and brain of long-term insulin-treated diabetic rats

1991 ◽  
Vol 28 (1) ◽  
pp. 11-18 ◽  
Author(s):  
Blanka Jamnicky ◽  
Milivoj Slijepčević ◽  
Mirko Hadžija ◽  
Dubravka Juretić ◽  
Olga Borčić
Keyword(s):  
Diabetic Rats ◽  
Tryptophan Content

Lack of glucagon response to hypoglycemia in long-term experimental diabetic rats

Diabetes ◽  
1983 ◽  
Vol 32 (1) ◽  
pp. 55-60 ◽  
Author(s):  
D. G. Patel
Keyword(s):  
Diabetic Rats

Hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin-induced diabetic rats

2016 ◽  
Vol 5 (06) ◽  
pp. 4641 ◽  
Author(s):  
Adel Abdel Moneim* ◽  
Sanaa M. Abd El-Twab ◽  
Mohamed B. Ashour ◽  
Ahmed I. Yousef
Keyword(s):  
Body Weight ◽  
Gallic Acid ◽  
Protein Profile ◽  
Serum Glucose ◽  
Diabetic Rats ◽  
Hypoglycemic Agents ◽  
Protective Effects ◽  
Coumaric Acid ◽  
Experimental Type

The goal of diabetes treatment is primarily to save life and alleviate symptoms and secondary to prevent long-term diabetic complications resulting from hyperglycemia. Thus, our present investigation was designed to evaluate the hepato-renal protective effects of gallic acid and p-coumaric acid in nicotinamide/streptozotocin (NA/STZ)-induced diabetic rats. Experimental type 2 diabetes was induced by a single intraperitoneal (i.p.) injection of STZ (65 mg/kg b.wt.), after 15 min of i.p. injection of NA (120 mg/kg b.wt.). Gallic acid and p-coumaric acid were orally administered to diabetic rats at a dose of 20, 40 mg/kg b.wt./day, respectively, for 6 weeks. Body weight, serum glucose, protein profile, liver function enzymes and kidney function indicators was assayed. Treatment with either gallic acid or p-coumaric acid significantly ameliorated the elevated levels of glucose, alanine aminotransferase (ALT), aspartate aminotransferase (AST), urea and uric acid. Both compounds were also found to restore total protein, albumin, and globulin as well as body weight of diabetic rats to near normal values. It can conclude that both gallic acid and p-coumaric acid have potent hypoglycemic and hepato-renal protective effects in diabetic rats. Therefore, our results suggest promising hypoglycemic agents that can attenuate the progression of diabetic hepatopathy and nephropathy.

Effect of chronic intraperitoneal aminoguanidine on memory and expression of Bcl-2 family genes in diabetic rats

2016 ◽  
Vol 94 (6) ◽  
pp. 669-675 ◽  
Author(s):  
Mohsen Alipour ◽  
Fatemeh Adineh ◽  
Hossein Mosatafavi ◽  
Azam Aminabadi ◽  
Hananeh Monirinasab ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Male Rats ◽  
Cognitive Tasks ◽  
Negative Effects ◽  
Gene Expressions ◽  
Family Gene ◽  
Higher Doses ◽  
With Memory ◽  
Hippocampal Apoptosis

Long-term hyperglycemia associates with memory defects via hippocampal cells damaging. The aim of the present study was to examine the effect of 1 month of i.p. injections of AG on passive avoidance learning (PAL) and hippocampal apoptosis in rat. Eighty male rats were divided into 10 groups: control, nondiabetics and STZ-induced diabetics treated with AG (50, 100, 200, and 400 mg/kg, i.p.). PAL and the Bcl-2 family gene expressions were determined. Diabetes resulted in memory and Bcl-2 family gene expression deficits. AG (50 and 100 mg/kg) significantly improved the learning and Bcl-2, Bcl-xl, Bax, and Bak impairment in diabetic rats. However, negative effects were indicated by higher doses of the drug (200 and 400 mg/kg). Present study suggests that 1 month of i.p. injections of lower doses of AG, may improve the impaired cognitive tasks in STZ-induced diabetic rats possibly by modulating Bcl-2 family gene expressions.

Long-Term Alpha-Lipoic Acid (ALA) Antioxidant Therapy Reduces Damage in the Cardiovascular System of Streptozotocin-Induced Diabetic Rats

2021 ◽  
pp. 1-15
Author(s):  
Cristiane Simões Coelho Britto Ramos ◽  
Vivian Alves Pereira da Silva ◽  
Lanna Beatriz Neves Silva Corrêa ◽  
Renato de Souza Abboud ◽  
Gilson Teles Boaventura ◽  
...  
Keyword(s):  
Cardiovascular System ◽  
Lipoic Acid ◽  
Diabetic Rats ◽  
Antioxidant Therapy ◽  
Alpha Lipoic Acid

scholarly journals Long-Term Acting and Orally Active Vanadyl-Methylpicolinate Complex with Hypoglycemic Activity in Streptozotocin-Induced Diabetic Rats.

1997 ◽  
Vol 23 (2) ◽  
pp. 113-129 ◽  
Author(s):  
Seiki FUJIMOTO ◽  
Kumiko FUJII ◽  
Hiroyuki YASUI ◽  
Rokuji MATSUSHITA ◽  
Jitsuya TAKADA ◽  
...  
Keyword(s):  
Diabetic Rats ◽  
Hypoglycemic Activity ◽  
Orally Active

scholarly journals Long term evaluation of morphometric and ultrastructural changes of testes of alloxan-induced diabetic rats

2013 ◽  
Vol 28 (4) ◽  
pp. 256-265 ◽  
Author(s):  
Amélia Arcângela Teixeira Trindade ◽  
Antônio Caetano Pereira Simões ◽  
Reinaldo José Silva ◽  
Célia Sperandeo Macedo ◽  
César Tadeu Spadella
Keyword(s):  
Diabetic Rats ◽  
Ultrastructural Changes ◽  
Term Evaluation

Super long-term glycemic control in diabetic rats by glucose-sensitive LbL films constructed of supramolecular insulin assembly

Biomaterials ◽  
2012 ◽  
Vol 33 (33) ◽  
pp. 8733-8742 ◽  
Author(s):  
Jun Luo ◽  
Shuqin Cao ◽  
Xingyu Chen ◽  
Shuning Liu ◽  
Hong Tan ◽  
...  
Keyword(s):  
Glycemic Control ◽  
Diabetic Rats ◽  
Lbl Films
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