A biomechanical study of osteoporotic vertebral trabecular bone: The use of micro-CT and high-resolution finite element analysis

2007 ◽  
Vol 21 (4) ◽  
pp. 593-601 ◽  
Author(s):  
Dae Gon Woo ◽  
Ye-Yeon Won ◽  
Han Sung Kim ◽  
Dohyung Lim
2006 ◽  
Vol 321-323 ◽  
pp. 278-281
Author(s):  
Wen Quan Cui ◽  
Ye Yeon Won ◽  
Myong Hyun Baek ◽  
Kwang Kyun Kim

The purpose of this study was to investigate the contribution of the microstructural properties of trabecular bone in predicting its elastic modulus in the intertrochanteric region. A total of 15 trabecular bone core specimens were obtained from the proximal femurs of patients undergoing total hip arthroplasty. The micro-computed tomography (micro-CT) was used to scan each specimen to obtain micro-morphology. Microstructural parameters were directly calculated using software. Micro-CT images were converted to micro-finite element model using meshing technique, and then micro-finite element analysis (FEA) was performed to assess the mechanical property (Young’s modulus) of trabecular bone. The results showed that the ability to explain this variance of Young’s modulus is improved by combining the structural indices with each other. It suggested that assessment of bone microarchitecture should be added as regards detection of osteoporosis and evaluation of the efficacy of drug treatments for osteoporosis.


2009 ◽  
Vol 42 (16) ◽  
pp. 2789-2796 ◽  
Author(s):  
P. Mc Donnell ◽  
N. Harrison ◽  
M.A.K. Liebschner ◽  
P.E. Mc Hugh

Author(s):  
Shashank Nawathe ◽  
Alissa Romens ◽  
Mary L. Bouxsein ◽  
Tony M. Keaveny

Despite the central role of femoral strength in the etiology of osteoporotic hip fractures [1], the associated micromechanical basis of femoral strength remains poorly understood. Cadaver studies [2] using biomechanical testing have established that both the cortical and trabecular bone contribute to the structural integrity of the proximal femur but these studies did not address mechanisms. Addressing mechanisms, theoretical and finite element continuum analyses have assessed cortical-trabecular load sharing and have described stress and strain distributions throughout the proximal femur [1,3]. However, the regions of the bone at highest risk of initial failure remain unclear, in part because the continuum nature and low spatial resolution of these previous analyses render them incapbable of capturing load transfer associated with the microstructure of the trabecular bone and the sometimes thin cortex. Overcoming this limitation, micro-CT-based finite element analysis has recently been applied to the entire proximal femur [4], but so far only two femurs have been analyzed and thus reported trends are difficult to generalize. To extend this recent work and provide further insight into the microstructural basis of femoral strength, we applied micro-CT based finite element analysis to investigate femoral micro-mechanics in a cohort of elderly human proximal femurs.


Author(s):  
Kangning Su ◽  
Yuxiao Zhou ◽  
Mehran Hossaini-Zadeh ◽  
Jing Du

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