Inhibitory effect of the somatostatin analog octreotide on rat pituitary tumor cell (GH3) proliferation in vitro

1990 ◽  
Vol 13 (8) ◽  
pp. 657-662 ◽  
Author(s):  
G. Pelicci ◽  
M. C. Pagliacci ◽  
L. Lanfrancone ◽  
P. G. Pelicci ◽  
F. Grignani ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Pituitary Tumor ◽  
Inhibitory Effect ◽  
Somatostatin Analog ◽  
Rat Pituitary ◽  
Proliferation In Vitro ◽  
Pituitary Tumor Cell

Inhibition of Rat Pituitary Tumor Cell Proliferation by Benzodiazepines in vitro

1994 ◽  
Vol 59 (1) ◽  
pp. 92-96 ◽  
Author(s):  
Jolanta Kunert-Radek ◽  
Henryk Stępień ◽  
Marek Pawlikowski
Keyword(s):  
Cell Proliferation ◽  
Tumor Cell ◽  
Pituitary Tumor ◽  
Tumor Cell Proliferation ◽  
Rat Pituitary ◽  
Pituitary Tumor Cell

scholarly journals Pituitary Tumor Suppression by Combination of Cabergoline and Chloroquine

2017 ◽  
Vol 102 (10) ◽  
pp. 3692-3703 ◽  
Author(s):  
Shao Jian Lin ◽  
Ze Rui Wu ◽  
Lei Cao ◽  
Yong Zhang ◽  
Zhi Gen Leng ◽  
...  
Keyword(s):  
Tumor Cell ◽  
Cell Lines ◽  
Pituitary Adenomas ◽  
Pituitary Tumor ◽  
Human Cancer ◽  
Primary Cultures ◽  
Human Pituitary ◽  
Pituitary Tumor Cell

Abstract Context The dopamine agonist cabergoline (CAB) has been used widely in the treatment of prolactinomas and other types of pituitary adenomas, but its clinical use is hampered by intolerance in some patients with prolactinoma and lack of effectiveness in other pituitary tumor types. Chloroquine (CQ) is an old drug widely used to treat malaria. Recent studies, including our own, have revealed that CAB and CQ are involved in induction of autophagy and activation of autophagic cell death. Objective To test whether CAB and CQ can function cooperatively to suppress growth of pituitary adenomas as well as other cancers. Results In vitro studies using the rat pituitary tumor cell lines MMQ and GH3, human pituitary tumor cell primary cultures, and several human cancer cell lines showed that CQ enhanced suppression of cell proliferation by CAB. These results were confirmed in in vivo xenograft models in nude mice and estrogen-induced rat prolactinomas. To understand the mechanism of combined CAB and CQ action, we established a low-CAB-dose condition in which CAB was able to induce autophagy but failed to suppress cell growth. Addition of CQ to low-dose CAB blocked normal autophagic cycles and induced apoptosis, evidenced by the further accumulation of p62/caspase-8/LC3-II. Conclusion The data suggest that combined use of CAB and CQ may increase clinical effectiveness in treatment of human pituitary adenomas, as well as other cancers, making it an attractive option in tumor and cancer therapies.

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