Pancreatic Cancer as a Model: Inflammatory Mediators, Acute-phase Response, and Cancer Cachexia

1999 ◽  
Vol 23 (6) ◽  
pp. 584-588 ◽  
Author(s):  
Kenneth C.H. Fearon ◽  
Matthew D. Barber ◽  
J.S. Falconer ◽  
Donald C. McMillan ◽  
James A. Ross ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Acute Phase ◽  
Inflammatory Mediators ◽  
Acute Phase Response ◽  
Cancer Cachexia ◽  
Phase Response

Resting energy expenditure, the acute phase response and cytokines in weight-losing patients with pancreatic cancer

1993 ◽  
Vol 12 ◽  
pp. 22
Author(s):  
J.S. Falconer ◽  
C.E. Plester ◽  
J.A. Ross ◽  
M.G. O'Riordain ◽  
D.C. Carter ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Energy Expenditure ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Resting Energy Expenditure ◽  
Phase Response ◽  
Resting Energy

scholarly journals Cytokines, the Acute-Phase Response, and Resting Energy Expenditure in Cachectic Patients with Pancreatic Cancer

1994 ◽  
Vol 219 (4) ◽  
pp. 325-331 ◽  
Author(s):  
J. Stuart Falconer ◽  
Kenneth C. H. Fearon ◽  
Claire E. Plester ◽  
James A Ross ◽  
David C. Carter
Keyword(s):  
Pancreatic Cancer ◽  
Energy Expenditure ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Resting Energy Expenditure ◽  
Phase Response ◽  
Resting Energy

scholarly journals STAT3 Activation in Skeletal Muscle Links Muscle Wasting and the Acute Phase Response in Cancer Cachexia

PLoS ONE ◽  
2011 ◽  
Vol 6 (7) ◽  
pp. e22538 ◽  
Author(s):  
Andrea Bonetto ◽  
Tufan Aydogdu ◽  
Noelia Kunzevitzky ◽  
Denis C. Guttridge ◽  
Sawsan Khuri ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Cancer Cachexia ◽  
Muscle Wasting ◽  
Phase Response

scholarly journals Fish Oil–Enriched Nutritional Supplement Attenuates Progression of the Acute-Phase Response in Weight-Losing Patients with Advanced Pancreatic Cancer

1999 ◽  
Vol 129 (6) ◽  
pp. 1120-1125 ◽  
Author(s):  
Matthew D. Barber ◽  
James A. Ross ◽  
Tom Preston ◽  
Alan Shenkin ◽  
Kenneth C. H. Fearon
Keyword(s):  
Pancreatic Cancer ◽  
Fish Oil ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Advanced Pancreatic Cancer ◽  
Nutritional Supplement ◽  
Phase Response

Down-Regulation of the Acute-Phase Response in Patients with Pancreatic Cancer Cachexia Receiving Oral Eicosapentaenoic Acid is Mediated via Suppression of Interleukin-6

1997 ◽  
Vol 92 (2) ◽  
pp. 215-221 ◽  
Author(s):  
Stephen J. Wigmore ◽  
Kenneth C. H. Fearon ◽  
Jean P. Maingay ◽  
James A. Ross
Keyword(s):  
Pancreatic Cancer ◽  
Eicosapentaenoic Acid ◽  
Acute Phase ◽  
Interleukin 6 ◽  
Peripheral Blood ◽  
Acute Phase Response ◽  
Cancer Cachexia ◽  
C Reactive Protein ◽  
Peripheral Blood Mononuclear ◽  
Reactive Protein

1. Weight loss in pancreatic cancer is associated with persistent elevation of the acute-phase protein response. The effect of oral administration of eicosapentaenoic acid on the regulation of the acute-phase response in weight-losing patients with pancreatic cancer was investigated in vitro and in vivo. 2. Oral supplementation with eicosapentaenoic acid, in patients with cancer cachexia, resulted in a significant reduction in the serum concentration of the acute-phase protein C-reactive protein (11.0 ± 4.8 mg/l before eicosapentaenoic acid compared with 0.8 ± 0.8 mg/l after 4 weeks of eicosapentaenoic acid, P < 0.05), but no significant reduction in the serum concentration of the hepatocyte-stimulating cytokine interleukin-6. Production of interleukin-6 by peripheral blood mononuclear cells isolated from patients was significantly reduced after supplementation with eicosapentaenoic acid (interleukin-6 production by peripheral blood mononuclear cells exposed to 10 μg of lipopolysaccharide/ml: 10.2 ± 2.1 ng/ml before supplementation with eicosapentaenoic acid compared with 3.5 ± 1.7 ng/ml after supplementation, P < 0.05) and supernatants from these cells had reduced potential to stimulate C-reactive protein production by isolated human hepatocytes (hepatocyte C-reactive protein production in response to supernatants from peripheral blood mononuclear cell cultures exposed to 10 μg of lipopolysaccharide/ml: 150.4 ± 18.6 ng/ml before eicosapentaenoic acid versus 118 ± 14.9 ng/ml after 4 weeks of eicosapentaenoic acid, P < 0.05). The potential of lipopolysaccharide-stimulated peripheral blood mononuclear cell supernatants to stimulate C-reactive protein production by hepatocytes could be attenuated by neutralizing anti-interleukin-6 antibody in control subjects and in patients before, but not after, treatment with eicosapentaenoic acid. 3. In conclusion, eicosapentaenoic acid can down-regulate the acute-phase response in patients with pancreatic cancer cachexia and this process is likely to involve suppression of interleukin-6 production.

Albumin synthesis rates, cytokines and the acute phase response in pancreatic cancer

1994 ◽  
Vol 13 ◽  
pp. 33-34
Author(s):  
J.S. Faiconer ◽  
C. Slater ◽  
K.C.H. Fearon ◽  
J.A. Ross ◽  
D.C. McMillan ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Albumin Synthesis

Expression changes of DOR and other thyroid hormone effector genes in rat liver during acute-phase response

2010 ◽  
Vol 48 (01) ◽  
Author(s):  
IA Malik ◽  
N Naz ◽  
F Moriconi ◽  
F Moriconi ◽  
B Baumgartner ◽  
...  
Keyword(s):  
Thyroid Hormone ◽  
Rat Liver ◽  
Acute Phase ◽  
Acute Phase Response ◽  
Phase Response ◽  
Effector Genes
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