Diphenyl diselenide reduces inflammation in the mouse model of pleurisy induced by carrageenan: reduction of pro-inflammatory markers and reactive species levels

Diabetes is a devastating global health problem and is considered a predisposing factor for lung injury progression. Furthermore, previous reports of the authors revealed the role of mediastinal fat-associated lymphoid clusters (MFALCs) in advancing respiratory diseases. However, no reports concerning the role of MFALCs on the development of lung injury in diabetes have been published. Therefore, this study aimed to examine the correlations between diabetes and the development of MFALCs and the progression of lung injury in a streptozotocin-induced diabetic mouse model. Furthermore, immunohistochemical analysis for immune cells (CD3+ T-lymphocytes, B220+ B-lymphocytes, Iba1+ macrophages, and Gr1+ granulocytes), vessels markers (CD31+ endothelial cells and LYVE-1+ lymphatic vessels “LVs”), and inflammatory markers (TNF-α and IL-5) was performed. In comparison to the control group, the diabetic group showed lung injury development with a significant increase in MFALC size, immune cells, LVs, and inflammatory marker, and a considerable decrease of CD31+ endothelial cells in both lung and MFALCs was observed. Furthermore, the blood glucose level showed significant positive correlations with MFALCs size, lung injury, immune cells, inflammatory markers, and LYVE-1+ LVs in lungs and MFALCs. Thus, we suggest that the development of MFALCs and LVs could contribute to lung injury progression in diabetic conditions.

Download Full-text

Enhanced pharmacological actions of p,p’ -methoxyl-diphenyl diselenide-loaded polymeric nanocapsules in a mouse model of neuropathic pain: Behavioral and molecular insights

Journal of Trace Elements in Medicine and Biology ◽

10.1016/j.jtemb.2017.11.002 ◽

2018 ◽

Vol 46 ◽

pp. 17-25 ◽

Cited By ~ 10

Author(s):

Marcel Henrique Marcondes Sari ◽

Vanessa Angonesi Zborowski ◽

Luana Mota Ferreira ◽

Natália da Silva Jardim ◽

Paulo Cesar Oliveira Araujo ◽

...

Keyword(s):

Neuropathic Pain ◽

Mouse Model ◽

Diphenyl Diselenide ◽

Polymeric Nanocapsules

Download Full-text

Zingerone Suppresses Liver Inflammation Induced by Antibiotic Mediated Endotoxemia through Down Regulating Hepatic mRNA Expression of Inflammatory Markers in Pseudomonas aeruginosa Peritonitis Mouse Model

PLoS ONE ◽

10.1371/journal.pone.0106536 ◽

2014 ◽

Vol 9 (9) ◽

pp. e106536 ◽

Cited By ~ 4

Author(s):

Lokender Kumar ◽

Sanjay Chhibber ◽

Kusum Harjai

Keyword(s):

Pseudomonas Aeruginosa ◽

Mouse Model ◽

Mrna Expression ◽

Inflammatory Markers ◽

Liver Inflammation

Download Full-text

Thymoquinone reduces mortality and suppresses early acute inflammatory markers of sepsis in a mouse model

Biomedicine & Pharmacotherapy ◽

10.1016/j.biopha.2018.01.028 ◽

2018 ◽

Vol 98 ◽

pp. 801-805 ◽

Cited By ~ 13

Author(s):

Khalid M. Alkharfy ◽

Ajaz Ahmad ◽

Basit L. Jan ◽

Mohammad Raish

Keyword(s):

Mouse Model ◽

Inflammatory Markers

Download Full-text

Effects of the MCP-1 synthesis inhibitor bindarit on tumorigenesis and inflammatory markers in the C3(1)/SV40Tag mouse model of breast cancer

Cytokine ◽

10.1016/j.cyto.2013.12.011 ◽

2014 ◽

Vol 66 (1) ◽

pp. 60-68 ◽

Cited By ~ 15

Author(s):

J.L. Steiner ◽

J.M. Davis ◽

J.L. McClellan ◽

A. Guglielmotti ◽

E.A. Murphy

Keyword(s):

Breast Cancer ◽

Mouse Model ◽

Inflammatory Markers ◽

Synthesis Inhibitor

Download Full-text

Oxalate modulates thiobarbituric acid reactive species (TBARS) production in supernatants of homogenates from rat brain, liver and kidney: Effect of diphenyl diselenide and diphenyl ditelluride

Chemico-Biological Interactions ◽

10.1016/j.cbi.2006.11.003 ◽

2007 ◽

Vol 165 (2) ◽

pp. 87-98 ◽

Cited By ~ 30

Author(s):

Robson Luiz Puntel ◽

Daniel Henrique Roos ◽

Márcio Weber Paixão ◽

Antônio Luiz Braga ◽

Gilson Zeni ◽

...

Keyword(s):

Rat Brain ◽

Thiobarbituric Acid ◽

Reactive Species ◽

Diphenyl Diselenide ◽

Diphenyl Ditelluride ◽

Liver And Kidney

Download Full-text

Dietary intervention with serum-derived bovine immunoglobulins protects barrier function in a mouse model of colitis

AJP Gastrointestinal and Liver Physiology ◽

10.1152/ajpgi.00378.2014 ◽

2015 ◽

Vol 308 (12) ◽

pp. G1012-G1018 ◽

Cited By ~ 18

Author(s):

Anna Pérez-Bosque ◽

Lluïsa Miró ◽

Mònica Maijó ◽

Javier Polo ◽

Joy Campbell ◽

...

Keyword(s):

Nitric Oxide ◽

Mouse Model ◽

Inducible Nitric Oxide Synthase ◽

Inflammatory Markers ◽

Dietary Intervention ◽

Dietary Supplementation ◽

Tnf Α ◽

Ifn Γ ◽

Oxide Synthase ◽

Inducible Nitric Oxide

Dietary supplementation with immunoglobulins from animal plasma has anti-inflammatory effects on intestinal and lung models of acute inflammation. Here, we aimed to establish whether dietary intervention with serum-derived bovine immunoglobulin (SBI) can prevent alterations in intestinal barrier function in a mouse model with a genetic predisposition to inflammatory bowel disease (IBD). Wild-type (WT) mice and mice lacking the mdr1a gene (KO) were fed diets supplemented with either SBI (2% wt/wt) or milk proteins (control diet), from day 21 (weaning) until day 56. The epithelial permeability of distal colon crypts was measured by confocal microscopy using a fluorescent marker. The expression of junctional epithelial E-cadherin and β-catenin proteins were determined by Western blot and zonula occludens-1 (ZO-1) by immunofluorescence. Mucins (MUC1, MUC2, MUC4), TFF3, cytokines (TNF-α, IFN-γ), and inducible nitric oxide synthase RNA expression were quantified by real-time PCR. SBI blocked the increase in colon crypt permeability and partially prevented the reduction in E-cadherin and ZO-1 expression that characterize the KO mouse model (both P < 0.05). SBI inclusion also reduced the mucosal expression of the inflammatory markers TNF-α, IFN-γ, and inducible nitric oxide synthase (all P < 0.005). The number of goblet cells in the colon of KO mice was low and correlated well with MUC2 and TFF3 expression ( P < 0.001), whereas dietary supplementation with SBI attenuated these effects (all P < 0.05). In short, dietary SBI ameliorated colonic barrier alterations and reduced the expression of mucosal inflammatory markers in a genetic model of IBD.

Download Full-text