Late radiation side effects, cosmetic outcomes and pain in breast cancer patients after breast-conserving surgery and three-dimensional conformal radiotherapy

2015 ◽  
Vol 192 (1) ◽  
pp. 8-16 ◽  
Author(s):  
Ursula Hille-Betz ◽  
Bernhard Vaske ◽  
Michael Bremer ◽  
Philipp Soergel ◽  
Sudip Kundu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Side Effects ◽  
Cancer Patients ◽  
Three Dimensional ◽  
Conformal Radiotherapy ◽  
Breast Conserving Surgery ◽  
Breast Cancer Patients ◽  
Cosmetic Outcomes ◽  
Three Dimensional Conformal Radiotherapy ◽  
Radiation Side Effects

Dosimetric analysis of intensity-modulated radiotherapy and three-dimensional conformal radiotherapy for chest wall irradiation in breast cancer patients

2015 ◽  
Vol 15 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Mehlam Kausar ◽  
Om Prakash Gurjar ◽  
Priyusha Bagdare ◽  
Krishna Lal Gupta ◽  
Virendra Bhandari ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Chest Wall ◽  
Three Dimensional ◽  
Intensity Modulated Radiotherapy ◽  
Conformal Radiotherapy ◽  
Breast Cancer Patients ◽  
Intensity Modulated ◽  
Significant Difference ◽  
Three Dimensional Conformal Radiotherapy

AbstractBackgroundFor chest wall irradiation in breast cancer patients, three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT) have made tremendous changes in treatment delivery.PurposeThe purpose of this study is to compare the dosimetric parameters in IMRT and 3DCRT plans.Materials and methodsIMRT and 3DCRT plans were generated for 25 randomly selected postmastectomy breast cancer patients. The prescribed dose (PD) was 50 Gray (Gy) in 25 fractions (#) at the rate of 2 Gy/# with 5#/week. Dose volume histogram was evaluated for planning target volume (PTV) coverage and dose to organs at risk (OARs). All the dosimetric parameters were compared using unpaired student’s t-test.ResultsPTV coverage was significantly better in IMRT, although the 90% of PTV was well covered by 90% of PD in all plans by both the techniques. Homogeneity index and conformity index were better in IMRT. V5 Gy and Dmean of contralateral lung, contralateral breast and heart (right side chest wall cases) were found to be lesser in 3DCRT compared with that in IMRT. However, there was no significant difference in V20 Gy of ipsilateral lung and V25 Gy of heart (left side chest wall cases) in all the plans by both the techniques.ConclusionAdequate target coverage was achieved by both the techniques, however, dose to OARs were lesser in 3DCRT plans as compared with that in IMRT plans. Thus, it can be concluded that 3DCRT is as efficient as IMRT for the chest wall irradiation.

scholarly journals Intensity-Modulated Radiation Therapy in Breast Cancer Patients Following the Release of a Choosing Wisely Recommendation

2019 ◽  
Vol 112 (3) ◽  
pp. 314-317
Author(s):  
Mylin A Torres ◽  
Keerthi Gogineni ◽  
David H Howard
Keyword(s):  
Breast Cancer ◽  
Radiation Therapy ◽  
Cancer Patients ◽  
Three Dimensional ◽  
Intensity Modulated Radiation Therapy ◽  
Conformal Radiotherapy ◽  
Breast Conserving Surgery ◽  
Breast Cancer Patients ◽  
Intensity Modulated ◽  
Percentage Points

Abstract In 2013, the American Society for Radiation Oncology recommended against the routine use of intensity-modulated radiation therapy (IMRT) in breast cancer patients. We evaluated trends in the use of IMRT before and after the release of the recommendation. Using Surveillance, Epidemiology, and End Results Medicare data, we identified 13 457 breast cancer patients diagnosed between 2012 and 2015 who received breast-conserving surgery and postsurgery, whole-breast, IMRT, or three-dimensional conformal radiotherapy. We find that the use of IMRT decreased by 4.6 (95% confidence interval [CI] = 3.6 to 5.6; two-sided P < .001) percentage points in hospital-based clinics. In freestanding radiotherapy clinics, which had baseline rates of IMRT use that were more than 20 percentage points higher than in hospital-based clinics, use of IMRT declined by 6.1 (95% CI = 3.5 to 8.7; two-sided P < .001) percentage points. Use of IMRT declined following the release of the recommendation, but a large share of patients treated in freestanding clinics continue to receive IMRT.

scholarly journals SYSTEMATIC REVIEW AND METAANALYSIS OF THE RESULTS OF BREAST-CONSERVING SURGERY AFTER NEOADJUVANT CHEMOTHERAPY IN BREAST CANCER PATIENTS

2021 ◽  
Vol 20 (2) ◽  
pp. 118-126
Author(s):  
A. R. Bosieva ◽  
M. V. Ermoshchenkova ◽  
A. D. Zikiryakhodzhayev ◽  
N. N. Volchenko
Keyword(s):  
Breast Cancer ◽  
Neoadjuvant Chemotherapy ◽  
Cancer Patients ◽  
Breast Tissue ◽  
Breast Conserving Surgery ◽  
Resection Margins ◽  
Breast Cancer Patients ◽  
Inclusion Criteria ◽  
Positive Resection Margins ◽  
Cosmetic Outcomes

Background. Neoadjuvant chemotherapy (NACT) is a standard of care for locally advanced breast cancer patients. One of the main advantages of NACT is the reduction of the tumor size and regression of lymph node metastasis.The aim of the study was to analyze the outcomes of breast-conserving surgery after NACT compared to adjuvant chemotherapy, including the examination of the width of resection margins and the frequency of re-operations, the volume of tissue removed and cosmetic outcomes.Material and Methods. We analyzed 1219 publications available from pubMed, Medline, Cochrane Library, 1057 of them did not meet the inclusion criteria, 162 publications were selected to cover all the following inclusion criteria: surgical margin status, frequency of re-operations, volume of tissue removed and cosmetic outcomes. Finally, 22 studies met fully specified criteria.Results. Studies included in this review demonstrated a different frequency of positive resection margins (2–39.8 %), reoperations (0–45.4 %), the volume of tissue removed (43.2–268 cm3), and the weight of the resected breast tissue (26.4–233 grams) after NACT.  Conclusion. The data obtained showed a decrease in the frequency of positive resection margins and re-operations in patients who received NACT compared to patients who did not receive NACT (5–39.8 % versus 13.1–46 % and 0–45.4 % versus 0–76.5 %, respectively), as well as a decrease in the amount of the removed breast tissue without the negative effect on the frequency of resection margins, thus allowing minimization of the extent of surgery and improvement of cosmetic outcomes.

scholarly journals Dosimetric comparison of Volumetric Modulated Arc Therapy and Three-Dimensional Conformal Radiotherapy during Post Mastectomy left chest wall Irradiation

2017 ◽  
Vol 2 (2) ◽  
Keyword(s):  
Breast Cancer ◽  
Volumetric Modulated Arc Therapy ◽  
Three Dimensional ◽  
Left Lung ◽  
Conformal Radiotherapy ◽  
Breast Cancer Patients ◽  
Arc Therapy ◽  
Three Dimensional Conformal Radiotherapy ◽  
Higher Doses ◽  
3D Crt

Aims: To dosimetrically evaluate the Volumetric Modulated Arc Therapy (VMAT) technique and compare it with Three-Dimensional Conformal Radiotherapy (3D-CRT) for postmastectomy breast cancer therapy. Methods and Material: Ten consecutively treated left sided breast cancer patients were selected for this study. VMAT plans were generated from each of the patients planning CT and compared with 3D-CRT plans. Statistical analysis used: Two tailed paired t test Results: The VMAT technique provided statistically significant homogenous and conformal dose distribution with mean HI of (0.1±0.02) and mean CI of (1.1±0.06) when compared mean HI of (0.3±0.02) and mean CI of (1.7±0.2) in the 3D-CRT technique. VMAT plans showed reduced V30 of the heart (10±4.54) when compared to 3D-CRT plans (15.1±8.53). Except V30, VMAT plans resulted in higher doses to heart. The mean doses received by left lung was (17.50±6.27) and was significantly higher than that of 3D-CRT plans (10.20±3.72). VMAT plans also gave higher doses to the contralateral lung and the opposite breast. Conclusions: VMAT plans in post mastectomy breast cancers provide more homogenous and conformal plans as compared to 3DCRT plans but higher doses to normal tissues.

scholarly journals Progression free survival in Iraqi breast cancer patients treated with adjuvant 3D conformal radiotherapy: A cross-sectional study

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 71
Author(s):  
Manwar Abdulelah Al-Naqqash ◽  
Enas Khudhair Al-Bdaer ◽  
Wieeam Abdulfattah Saleh Saleh ◽  
Ahmed Salih Al-Shewered
Keyword(s):  
Breast Cancer ◽  
Three Dimensional ◽  
Progression Free Survival ◽  
Conformal Radiotherapy ◽  
Breast Conserving Surgery ◽  
Cross Sectional Study ◽  
Breast Cancer Patients ◽  
Luminal A ◽  
Cross Sectional ◽  
Free Survival

Background: Breast cancer is a common malignancy in Iraq, accounting for one-third of female cancers in the Iraqi Cancer Registry. Radiotherapy confers benefits for local control and progression free survival (PFS) in patients with breast cancer. This study aimed to assess PFS in patients treated by hypofractionated three-dimensional conformal radiotherapy (3DCRT) and correlate PFS with patients' clinical and pathological profiles. Methods: We retrospectively reviewed 299 women with breast cancer treated at Baghdad Radiation Oncology Center between October 2017 and May 2018. Regarding radiotherapy, 4005 cGy in 15 fractions over 3 weeks was adopted as standard practice for patients undergoing mastectomy and 4005 cG in 15 fractions + 1000 cG in 5 fractions as a booster dose for women undergoing breast-conserving surgery. Results: Age ranged from 25 to 75 years, and the mean age was 49.9±10.99 years. The most common stage was T2 (156, 53.9%), which mostly comprised luminal A (105, 36.3%). The results showed a high frequency of N1 (109, 37.2%), with luminal A (69, 23.4%). Relapse occurred in 35/299 (11.7%) patients, and the chest wall was a common relapse site in 9 of these patients (25.9%). Conclusions: We conclude that adjuvant radiotherapy reduces locoregional recurrence, distant metastasis and mortality rate.

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