scholarly journals Factors of influence on acute skin toxicity of breast cancer patients treated with standard three-dimensional conformal radiotherapy (3D-CRT) after breast conserving surgery (BCS)

2012 ◽  
Vol 7 (1) ◽  
Author(s):  
Uta Kraus-Tiefenbacher ◽  
Andreas Sfintizky ◽  
Grit Welzel ◽  
Anna Simeonova ◽  
Elena Sperk ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Three Dimensional ◽  
Conformal Radiotherapy ◽  
Skin Toxicity ◽  
Breast Conserving Surgery ◽  
Breast Cancer Patients ◽  
Acute Skin Toxicity ◽  
Factors Of Influence ◽  
Three Dimensional Conformal Radiotherapy ◽  
3D Crt

scholarly journals Dosimetric comparison of Volumetric Modulated Arc Therapy and Three-Dimensional Conformal Radiotherapy during Post Mastectomy left chest wall Irradiation

2017 ◽  
Vol 2 (2) ◽  
Keyword(s):  
Breast Cancer ◽  
Volumetric Modulated Arc Therapy ◽  
Three Dimensional ◽  
Left Lung ◽  
Conformal Radiotherapy ◽  
Breast Cancer Patients ◽  
Arc Therapy ◽  
Three Dimensional Conformal Radiotherapy ◽  
Higher Doses ◽  
3D Crt

Aims: To dosimetrically evaluate the Volumetric Modulated Arc Therapy (VMAT) technique and compare it with Three-Dimensional Conformal Radiotherapy (3D-CRT) for postmastectomy breast cancer therapy. Methods and Material: Ten consecutively treated left sided breast cancer patients were selected for this study. VMAT plans were generated from each of the patients planning CT and compared with 3D-CRT plans. Statistical analysis used: Two tailed paired t test Results: The VMAT technique provided statistically significant homogenous and conformal dose distribution with mean HI of (0.1±0.02) and mean CI of (1.1±0.06) when compared mean HI of (0.3±0.02) and mean CI of (1.7±0.2) in the 3D-CRT technique. VMAT plans showed reduced V30 of the heart (10±4.54) when compared to 3D-CRT plans (15.1±8.53). Except V30, VMAT plans resulted in higher doses to heart. The mean doses received by left lung was (17.50±6.27) and was significantly higher than that of 3D-CRT plans (10.20±3.72). VMAT plans also gave higher doses to the contralateral lung and the opposite breast. Conclusions: VMAT plans in post mastectomy breast cancers provide more homogenous and conformal plans as compared to 3DCRT plans but higher doses to normal tissues.

scholarly journals A COMPARATIVE DOSIMETRIC STUDY OF LEFT SIDED BREAST CANCER AFTER BREAST CONSERVING SURGERY WITH 3D-CRT AND VMAT

2020 ◽  
Vol 8 (11) ◽  
pp. 1088-1093
Author(s):  
F. Kouhen ◽  
◽  
H.El Gouache ◽  
M. Bensediq ◽  
K. Saadi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Volumetric Modulated Arc Therapy ◽  
Three Dimensional ◽  
Conformal Radiotherapy ◽  
Breast Conserving Surgery ◽  
Left Breast ◽  
Conformity Index ◽  
Clinical Value ◽  
Three Dimensional Conformal Radiotherapy ◽  
3D Crt

Purpose: This paper aims to compare dosimetric differences based between three-dimensional conformal radiotherapy (3D-CRT), and volumetric modulated arc therapy(VMAT) techniques of radiotherapy plans for postoperative left breast cancer after breast conserving surgery. Materials and Methods: Nineteen patients with left breast cancer who had received breast conserving surgery without nodal involvement. Two separate treatment plans with an identical isocenter were created to each patient: 3D radiotherapy plan with 2 tangent isocentric beams with field-in-field technique andVMAT plan with Two duplicate sets of partial arcs. Results: The VMAT plan showed superior to PTV dose conformity index (CI), homogeneity index (HI), protection of the ipsilateral lung, and heart compared with 3D plan. However, it increases significantly dose to the contralateral breast with D mean which were 0.1±0.003 Gy and 5.31±1.04 Gy, respectively. Conclusion: VMAT greatly decreases the radiation doses delivered to the OAR with maintained therapeutic efficacy.However, further studies evaluating the clinical outcome of treatments are needed to proof the clinical value of this radiation technique.

Common variants of eNOS and XRCC1 genes may predict acute skin toxicity in breast cancer patients receiving radiotherapy after breast conserving surgery

2012 ◽  
Vol 103 (2) ◽  
pp. 199-205 ◽  
Author(s):  
Salvatore Terrazzino ◽  
Pierdaniele La Mattina ◽  
Laura Masini ◽  
Tina Caltavuturo ◽  
Giuseppina Gambaro ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Skin Toxicity ◽  
Breast Conserving Surgery ◽  
Common Variants ◽  
Breast Cancer Patients ◽  
Acute Skin Toxicity

Dosimetric analysis of intensity-modulated radiotherapy and three-dimensional conformal radiotherapy for chest wall irradiation in breast cancer patients

2015 ◽  
Vol 15 (1) ◽  
pp. 30-37 ◽  
Author(s):  
Mehlam Kausar ◽  
Om Prakash Gurjar ◽  
Priyusha Bagdare ◽  
Krishna Lal Gupta ◽  
Virendra Bhandari ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Chest Wall ◽  
Three Dimensional ◽  
Intensity Modulated Radiotherapy ◽  
Conformal Radiotherapy ◽  
Breast Cancer Patients ◽  
Intensity Modulated ◽  
Significant Difference ◽  
Three Dimensional Conformal Radiotherapy

AbstractBackgroundFor chest wall irradiation in breast cancer patients, three-dimensional conformal radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT) have made tremendous changes in treatment delivery.PurposeThe purpose of this study is to compare the dosimetric parameters in IMRT and 3DCRT plans.Materials and methodsIMRT and 3DCRT plans were generated for 25 randomly selected postmastectomy breast cancer patients. The prescribed dose (PD) was 50 Gray (Gy) in 25 fractions (#) at the rate of 2 Gy/# with 5#/week. Dose volume histogram was evaluated for planning target volume (PTV) coverage and dose to organs at risk (OARs). All the dosimetric parameters were compared using unpaired student’s t-test.ResultsPTV coverage was significantly better in IMRT, although the 90% of PTV was well covered by 90% of PD in all plans by both the techniques. Homogeneity index and conformity index were better in IMRT. V5 Gy and Dmean of contralateral lung, contralateral breast and heart (right side chest wall cases) were found to be lesser in 3DCRT compared with that in IMRT. However, there was no significant difference in V20 Gy of ipsilateral lung and V25 Gy of heart (left side chest wall cases) in all the plans by both the techniques.ConclusionAdequate target coverage was achieved by both the techniques, however, dose to OARs were lesser in 3DCRT plans as compared with that in IMRT plans. Thus, it can be concluded that 3DCRT is as efficient as IMRT for the chest wall irradiation.

scholarly journals Progression free survival in Iraqi breast cancer patients treated with adjuvant 3D conformal radiotherapy: A cross-sectional study

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 71
Author(s):  
Manwar Abdulelah Al-Naqqash ◽  
Enas Khudhair Al-Bdaer ◽  
Wieeam Abdulfattah Saleh Saleh ◽  
Ahmed Salih Al-Shewered
Keyword(s):  
Breast Cancer ◽  
Three Dimensional ◽  
Progression Free Survival ◽  
Conformal Radiotherapy ◽  
Breast Conserving Surgery ◽  
Cross Sectional Study ◽  
Breast Cancer Patients ◽  
Luminal A ◽  
Cross Sectional ◽  
Free Survival

Background: Breast cancer is a common malignancy in Iraq, accounting for one-third of female cancers in the Iraqi Cancer Registry. Radiotherapy confers benefits for local control and progression free survival (PFS) in patients with breast cancer. This study aimed to assess PFS in patients treated by hypofractionated three-dimensional conformal radiotherapy (3DCRT) and correlate PFS with patients' clinical and pathological profiles. Methods: We retrospectively reviewed 299 women with breast cancer treated at Baghdad Radiation Oncology Center between October 2017 and May 2018. Regarding radiotherapy, 4005 cGy in 15 fractions over 3 weeks was adopted as standard practice for patients undergoing mastectomy and 4005 cG in 15 fractions + 1000 cG in 5 fractions as a booster dose for women undergoing breast-conserving surgery. Results: Age ranged from 25 to 75 years, and the mean age was 49.9±10.99 years. The most common stage was T2 (156, 53.9%), which mostly comprised luminal A (105, 36.3%). The results showed a high frequency of N1 (109, 37.2%), with luminal A (69, 23.4%). Relapse occurred in 35/299 (11.7%) patients, and the chest wall was a common relapse site in 9 of these patients (25.9%). Conclusions: We conclude that adjuvant radiotherapy reduces locoregional recurrence, distant metastasis and mortality rate.

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