Reply to Comment on: Mackin P, Watkinson HM, Young AH (2005) Prevalence of obesity, glucose homeostasis disorders and metabolic syndrome in psychiatric patients taking typical or atypical antipsychotic drugs: a cross-sectional study. Diabetologia 48:215–221

Background: Schizophrenia is a chronic debilitating major psychiatric illness which is characterized by a decreased ability to understand reality, strange speech and abnormal behavior. Aims: To find out pharmacological patterns in schizophrenic patients. Materials & Methods: The present observational cross-sectional study involved prescription of 150 schizophrenic patients and was conducted in the outpatient department (OPD) of tertiary care hospital, Jammu over a period of two months. Data like name, number, combination of drugs etc of psychotropic medications were collected Results: Average number of drugs per prescription was 2.26. Among prescribed antipsychotics, 87.9% were atypical antipsychotic drugs. Single antipsychotic was used in 57.3% patients whereas combination of antipsychotics were used in 42.7% patients. Olanzapine was the most commonly used antipsychotic drug and was prescribed in 72.7% patients. Benzodiazepines were the most commonly used comedications and were prescribed in 62% patients. Conclusion: From present study, it has been concluded that atypical antipsychotic drugs were the most frequently prescribed among schizophrenic patients. The most common medication to be used was olanzapine whereas the most common comedications used along with antipsychotics were benzodiazepines. Keywords: Antipsychotics, Olanzapine, Schizophrenia.

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Magnitude of metabolic syndrome and its predictors among patients on second-generation antipsychotic drugs at six psychiatry clinics and mental hospitals, in Addis Ababa, Ethiopia, 2019; Multicenter cross-sectional study

Diabetes & Metabolic Syndrome Clinical Research & Reviews ◽

10.1016/j.dsx.2021.102187 ◽

2021 ◽

pp. 102187

Author(s):

Getasew Amogne ◽

Tadesse Alemu ◽

Trhas Tadesse ◽

Assefa Mullu

Keyword(s):

Metabolic Syndrome ◽

Antipsychotic Drugs ◽

Second Generation ◽

Addis Ababa ◽

Cross Sectional Study ◽

Sectional Study ◽

Cross Sectional ◽

Mental Hospitals ◽

Second Generation Antipsychotic

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Metabolic syndrome and associated factors among severely ill psychiatric and non-psychiatric patients: a comparative cross-sectional study in Eastern Ethiopia

Diabetology & Metabolic Syndrome ◽

10.1186/s13098-021-00750-4 ◽

2021 ◽

Vol 13 (1) ◽

Author(s):

Dilnessa Fentie ◽

Tariku Derese ◽

Bekele Yazie ◽

Yibeltal Getachew

Keyword(s):

Metabolic Syndrome ◽

Psychiatric Disorders ◽

Psychiatric Patients ◽

Fasting Blood Glucose ◽

Density Lipoprotein ◽

Cross Sectional Study ◽

Mitigation Strategies ◽

Sectional Study ◽

Cross Sectional ◽

Eastern Ethiopia

Abstract Background Metabolic syndrome is a major public health challenge in both developed and developing countries. The burden of this disease is high, even in patients with psychiatric disorders. However, very little is known about the association between metabolic syndrome and psychiatric illness in Ethiopia. Therefore, the aim of this study was to investigate the magnitude of metabolic syndrome and its components among psychiatric clients. Methods A comparative cross-sectional study was undertaken between psychiatric patients and age—and sex-matched non-psychiatric controls at the Dilchora referral hospital. The study included 192 study participants (96 psychiatric patients and 96 non- psychiatric controls from general medical and surgical patients). The National Cholesterol Education Program: Adult Treatment Panel III criteria were used to diagnose metabolic syndromes. The data were cleaned and analyzed using the Statistical Package for Social Sciences, Version 21. All intergroup comparisons for continuous data were performed using an independent sample t-test, whereas categorical data were analyzed using the Chi-square test. Logistic regression analysis was used to identify the association between metabolic syndrome and the associated variables. Results The magnitude of metabolic syndrome among psychiatric patients was 36.5% (95%CI: 27.6, 47.4) compared to non-psychiatric control patients, 21.9% (95%CI: 13.5, 30.3), p = 0.02. The prevalence of MetS components, such as waist circumference (25.0% vs. 14.3%), lower-high density lipoprotein level (35.4% vs. 20.8%), higher systolic blood pressure (41.7% vs. 29.2%) and higher fasting blood glucose (40.6% vs. 18.8%) showed statistically significant differences between the exposed and non-exposed groups. Age greater than 50 years (AOR: 2.8, CI: 1.14, 20.0, p < 0.05); being female (AOR: 7.4, CI: 2.0, 27.6, p < 0.05), being urban residence (AOR: 6.4, CI: 2.2, 20.6, p < 0.05), ever alcohol intake (AOR: 5.3, CI: 1.3, 21.2), being physically inactive (AOR: 3.52, CI: 1.1, 12.9, p < 0.05) and family history of hypertension (AOR: 2.52, CI: 1.1, 12.2, p < 0.05) were independent predictors of metabolic syndrome (p < 0.05). Conclusions There is a high burden of metabolic syndrome and its components in patients with severe psychiatric disorders. Therefore, screening and mitigation strategies for metabolic syndrome and their components should be implemented in the management of psychiatric disorders.

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