Prevalence of type 2 diabetes in psychiatric disorders: an umbrella review with meta-analysis of 245 observational studies from 32 systematic reviews

Diabetologia ◽  
2021 ◽  
Author(s):  
Nanna Lindekilde ◽  
Stine H. Scheuer ◽  
Femke Rutters ◽  
Lenette Knudsen ◽  
Mathias Lasgaard ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Psychiatric Disorders ◽  
Systematic Reviews ◽  
Observational Studies ◽  
Meta Analysis ◽  
Umbrella Review

scholarly journals Psychiatric disorders as risk factors for the development of type 2 diabetes mellitus: an umbrella review protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (5) ◽  
pp. e024981 ◽  
Author(s):  
Nanna Lindekilde ◽  
Giesje Nefs ◽  
Jan Erik Henriksen ◽  
Mathias Lasgaard ◽  
Miranda Schram ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Psychiatric Disorders ◽  
Systematic Reviews ◽  
Future Research ◽  
Umbrella Review ◽  
Mediating Mechanisms ◽  
Meta Analyses

IntroductionNumerous longitudinal studies, systematic reviews and meta-analyses have examined psychiatric disorders as risk factors for the development of type 2 diabetes mellitus. A more comprehensive overview of the area is warranted to summarise current evidence and discuss strengths and weaknesses to guide future research.AimThe aim of this umbrella review is to determine whether and to what extent different psychiatric disorders are associated with the development of type 2 diabetes mellitus. Furthermore, the umbrella review also assesses the evidence on potential mediating mechanisms.Methods and analysisThe present umbrella review will consist of a comprehensive systematic search of published systematic reviews and meta-analyses of observational longitudinal studies investigating whether a psychiatric disorder is associated with the risk of developing type 2 diabetes. PubMed, Embase, PsychINFO and the Cochrane Database of Systematic Reviews will be searched, and the results will be screened for inclusion by two independent reviewers. Furthermore, the reference lists of included publications will be manually searched. Two independent reviewers will extract data and assess the methodological quality in the included systematic reviews and meta-analyses. Evidence on potential mediating mechanisms included in the systematic reviews and meta-analyses will also be reviewed. The implications of the overview will be discussed in light of the quality of the included studies, and suggestions for clinical practice and future research will be made.Ethics and disseminationEthical approval is not required for this umbrella review. Our review will be submitted for publication in a peer-reviewed international journal using open access option if available. The results will also be disseminated at international conferences.PROSPERO registration numberCRD42018096362

scholarly journals Psychiatric disorders as risk factors for type 2 diabetes: an umbrella review of systematic reviews with and without meta-analyses

2021 ◽  
pp. 108855
Author(s):  
Nanna Lindekilde ◽  
Femke Rutters ◽  
Jan Erik Henriksen ◽  
Mathias Lasgaard ◽  
Miranda T. Schram ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Psychiatric Disorders ◽  
Systematic Reviews ◽  
Umbrella Review ◽  
Meta Analyses

Cinammon (Cinnamomum Spp.) and Type 2 Diabetes Mellitus

2019 ◽  
Vol 18 (3) ◽  
pp. 247-255
Author(s):  
Sierra-Puente D. ◽  
Abadi-Alfie S. ◽  
Arakanchi-Altaled K. ◽  
Bogard-Brondo M. ◽  
García-Lascurain M. ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Systematic Reviews ◽  
Meta Analysis ◽  
Fasting Blood Glucose ◽  
Tolerance Test ◽  
Oral Glucose ◽  
Key Aspects

Spices such as cinnamon (Cinnamomum Spp.) have been of interest due to their phytochemical composition that exert hypoglycemic effects with potential for management of type 2 diabetes mellitus (T2DM). We summarize data from 27 manuscripts that include, one book chapter, 3 review articles, 10 randomized controlled trials, 4 systematic reviews with meta-analysis, and 9 preclinical studies. The most frequently used cinnamon variety was Cinnamomum cassia rather than the Cinnamomum zeylanicum, whereas outcomes were defined as fasting blood glucose, glycated hemoglobin, and oral glucose tolerance test. A great variability in methodology such as different doses (from 120 mg to 6 g), duration of intervention, data retrieved and use of different concomitant medication, were found to be key aspects of most of trials and systematic reviews with meta-analysis available to date. Low quality studies have been made in most cases with a lot of heterogeneity clouding significance of results. More research needs to be done in order to yield accurate evidence for evidence-based recommendations. Its use is not currently a reliable nor advisable option for the treatment of T2DM.

Water intake and risk of type 2 diabetes: A systematic review and meta-analysis of observational studies

2021 ◽  
Author(s):  
Nasim Janbozorgi ◽  
Ramesh Allipour ◽  
Kurosh Djafarian ◽  
Sakineh Shab-Bidar ◽  
Mostafa Badeli ◽  
...  
Keyword(s):  
Systematic Review ◽  
Type 2 Diabetes ◽  
Water Intake ◽  
Observational Studies ◽  
Meta Analysis

scholarly journals Breakfast skipping and the risk of type 2 diabetes: a meta-analysis of observational studies

2015 ◽  
Vol 18 (16) ◽  
pp. 3013-3019 ◽  
Author(s):  
Huashan Bi ◽  
Yong Gan ◽  
Chen Yang ◽  
Yawen Chen ◽  
Xinyue Tong ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Observational Studies ◽  
Meta Analysis ◽  
Adjusted Relative Risk ◽  
China National Knowledge Infrastructure ◽  
Cross Sectional ◽  
Breakfast Skipping ◽  
Risk Estimates ◽  
Increased Risk

AbstractObjectiveBreakfast skipping has been reported to be associated with type 2 diabetes (T2D), but the results are inconsistent. No meta-analyses have applied quantitative techniques to compute summary risk estimates. The present study aimed to conduct a meta-analysis of observational studies summarizing the evidence on the association between breakfast skipping and the risk of T2D.DesignSystematic review and meta-analysis.SettingRelevant studies were identified by a search of PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI) and SINOMED up to 9 August 2014. We also reviewed reference lists from retrieved articles. We included studies that reported risk estimates (including relative risks, odds ratios and hazard ratios) with 95 % confidence intervals for the association between breakfast skipping and the risk of T2D.SubjectsEight studies involving 106 935 participants and 7419 patients with T2D were included in the meta-analysis.ResultsA pooled adjusted relative risk for the association between exposure to breakfast skipping and T2D risk was 1·21 (95 % CI 1·12, 1·31; P=0·984; I2=0·0 %) in cohort studies and the pooled OR was 1·15 (95 % CI, 1·05, 1·24; P=0·770; I2=0·0 %) in cross-sectional studies. Visual inspection of a funnel plot and Begg’s test indicated no evidence of publication bias.ConclusionsBreakfast skipping is associated with a significantly increased risk of T2D. Regular breakfast consumption is potentially important for the prevention of T2D.

scholarly journals Risk of Fracture in Type 2 Diabetes Mellitus Patients: Meta-Analysis of Observational Studies

2015 ◽  
Vol 18 (7) ◽  
pp. A601 ◽  
Author(s):  
C Shah ◽  
R Shah ◽  
G Kinra ◽  
S Singuru ◽  
M Naidu ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Observational Studies ◽  
Meta Analysis ◽  
Risk Of Fracture
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