High prevalence of a missense mutation of the glucokinase gene in gestational diabetic patients due to a founder-effect in a local population

Abstract Diabetes is an “epidemic of the 21st century” and it is estimated that in 2011 6.7% of Poland’s population suffered from diabetes, one quarter of which was unaware of the disease. Such a high prevalence of diabetes mellitus results in an increasing number of physicians being confronted with the problem of qualifying patient with diabetes to partake in amateur sports, including diving. This publication presents the most important information concerning risk assessment, admission of diabetic patients to amateur diving and some proposed protocols of management before and during sport practice.

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Hypertension and Micro-Vascular Complications Among Type 2 Dm Adult Patients in Mukalla, Yemen

Journal of Clinical Research and Reports ◽

10.31579/2690-1919/056 ◽

2020 ◽

Vol 3 (5) ◽

pp. 01-04

Author(s):

Abdullah Ghouth

Keyword(s):

Care Center ◽

Vascular Complications ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Cross Sectional ◽

Health Care Center ◽

Age Related ◽

Significant Difference ◽

High Prevalence

The Background and Purpose: to assess the prevalence of hypertension and micro-vascular complications among type 2 diabetic patients registered in primary health care center in Mukalla city at eastern Yemen. Methods: A Cross-sectional study was conducted in a randomly selected eligible patients from the diabetic registry of the AL Noor Charity Center (ACC), Mukalla city in Yemen. Results: Prevalence of hypertension in the T2DM patients were 46.7% (56/120). Retinopathy is the most micro-vascular complications among the adults having T2DM (73/120, 60.8%) while nephropathy is the least prevalence (13/120, 10.8%), prevalence of neuropathy was 49.2% (59/120). a high prevalence of retinopathy in males (66%) than females (55.7%) and a high prevalence of neuropathy in male adults (52.2%) than females (46%).No statistical significant difference were exit related to gender for any studied complications. Similar findings were observed regarding age related variations. Conclusion: A high prevalence of hypertension, retinopathy and neuropathy were reported among T2DM patients in Mukalla. Adopting effective and safe treatment strategies are highly recommended to prevent premature death and complications due to DM.

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Current NAFLD guidelines for risk stratification in diabetic patients have poor diagnostic discrimination

Scientific Reports ◽

10.1038/s41598-020-75227-x ◽

2020 ◽

Vol 10 (1) ◽

Author(s):

Valentin Blank ◽

David Petroff ◽

Sebastian Beer ◽

Albrecht Böhlig ◽

Maria Heni ◽

...

Keyword(s):

Risk Stratification ◽

Liver Stiffness ◽

Diabetic Patients ◽

Alcoholic Fatty Liver ◽

Referral Rates ◽

Specialist Referral ◽

High Prevalence ◽

Referral Strategy ◽

Sensitivity Specificity ◽

Diagnostic Pathways

Abstract Patients with type 2 diabetes (T2D) are at risk for non-alcoholic fatty liver disease (NAFLD) and associated complications. This study evaluated the performance of international (EASL-EASD-EASO) and national (DGVS) guidelines for NAFLD risk stratification. Patients with T2D prospectively underwent ultrasound, liver stiffness measurement (LSM) and serum-based fibrosis markers. Guideline-based risk classification and referral rates for different screening approaches were compared and the diagnostic properties of simplified algorithms, genetic markers and a new NASH surrogate (FAST score) were evaluated. NAFLD risk was present in 184 of 204 screened patients (age 64.2 ± 10.7 years; BMI 32.6 ± 7.6 kg/m2). EASL-EASD-EASO recommended specialist referral for 60–77% depending on the fibrosis score used, only 6% were classified as low risk. The DGVS algorithm required LSM for 76%; 25% were referred for specialised care. The sensitivities of the diagnostic pathways were 47–96%. A simplified referral strategy revealed a sensitivity/specificity of 46/88% for fibrosis risk. Application of the FAST score reduced the referral rate to 35%. This study (a) underlines the high prevalence of fibrosis risk in T2D, (b) demonstrates very high referral rates for in-depth hepatological work-up, and (c) indicates that simpler referral algorithms may produce comparably good results and could facilitate NAFLD screening.

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The high prevalence of malnutrition in elderly diabetic patients: implications for anti-diabetic drug treatments

Diabetic Medicine ◽

10.1111/j.1464-5491.2010.03047.x ◽

2010 ◽

Vol 27 (8) ◽

pp. 918-924 ◽

Cited By ~ 40

Author(s):

U. M. Vischer ◽

L. Perrenoud ◽

C. Genet ◽

S. Ardigo ◽

Y. Registe-Rameau ◽

...

Keyword(s):

Diabetic Patients ◽

High Prevalence ◽

Drug Treatments

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Mutation Screening of theHGDGene Identifies a Novel Alkaptonuria Mutation with Significant Founder Effect and High Prevalence

Annals of Human Genetics ◽

10.1111/ahg.12055 ◽

2014 ◽

Vol 78 (3) ◽

pp. 155-164 ◽

Cited By ~ 12

Author(s):

Srinivasan Sakthivel ◽

Andrea Zatkova ◽

Martina Nemethova ◽

Milan Surovy ◽

Ludevit Kadasi ◽

...

Keyword(s):

Founder Effect ◽

Mutation Screening ◽

High Prevalence

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High prevalence of exercise-induced ischemia in the asymptomatic limb of patients with apparently strictly unilateral symptoms and unilateral peripheral artery disease

Therapeutic Advances in Cardiovascular Disease ◽

10.1177/1753944718819063 ◽

2019 ◽

Vol 13 ◽

pp. 175394471881906 ◽

Cited By ~ 2

Author(s):

Samir Henni ◽

Pascal Bauer ◽

Tanguy Le Meliner ◽

Jeanne Hersant ◽

Xavier Papon ◽

...

Keyword(s):

Pressure Drop ◽

Peripheral Artery Disease ◽

Systolic Pressure ◽

Diabetic Patients ◽

Peripheral Artery ◽

Pressure Index ◽

High Prevalence ◽

Artery Disease ◽

Exercise Induced ◽

Brachial Systolic Pressure

Background: The prevalence of exercise-induced ischemia in the asymptomatic limb of patients with unilateral claudication based on history and treadmill evaluation, and with unilateral ipsilateral peripheral artery disease (i.e ankle-to-brachial systolic pressure index <0.90) is unknown. Methods: We detected exercise-induced ischemia in the asymptomatic limb of patients with apparently unilateral claudication. Among 6059 exercise-oximetry tests performed in 3407 nondiabetic and 961 diabetic patients. We estimated the intensity of ischemia in the both limb (buttocks and calves) using the lowest minimum value of the decrease from rest of oxygen pressure (DROP; limb changes minus chest changes from rest), with significant ischemia defined as DROP lower than −15 mmHg. Results: We found 152 tests performed in 142 nondiabetic patients and 40 tests performed in 38 diabetic patients. The asymptomatic limb showed significant ischemia in 46.7% and 37.5% of the tests. Strictly unilateral exercise-induced claudication with apparently unilateral peripheral artery disease was rare (<4% of all tests). However, among these highly selected tests, significant ischemia was found in the asymptomatic limb in more than one-third of cases. Conclusion: The asymptomatic limb of patients with peripheral artery disease should not be considered a normal limb.

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