Returning home after intensive care: A comparison of symptoms of anxiety and depression in ICU and elective cardiac surgery patients and their relatives

2004 ◽  
Vol 31 (1) ◽  
pp. 86-91 ◽  
Author(s):  
Ellen Young ◽  
Jane Eddleston ◽  
Sarah Ingleby ◽  
Janice Streets ◽  
Lucy McJanet ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Intensive Care ◽  
Anxiety And Depression ◽  
Elective Cardiac Surgery ◽  
Returning Home

Esmolol before cardioplegia and as cardioplegia adjuvant reduces cardiac troponin release after cardiac surgery. A randomized trial

Perfusion ◽  
2016 ◽  
Vol 32 (4) ◽  
pp. 313-320 ◽  
Author(s):  
Elena Bignami ◽  
Marcello Guarnieri ◽  
Annalisa Franco ◽  
Chiara Gerli ◽  
Monica De Luca ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Cardiac Surgery ◽  
Intensive Care ◽  
Placebo Group ◽  
Cardiopulmonary Bypass ◽  
Hospital Stay ◽  
Troponin T ◽  
Mechanical Activity ◽  
Double Blind ◽  
Elective Cardiac Surgery

Background: Cardioplegic solutions are the standard in myocardial protection during cardiac surgery, since they interrupt the electro-mechanical activity of the heart and protect it from ischemia during aortic cross-clamping. Nevertheless, myocardial damage has a strong clinical impact. We tested the hypothesis that the short-acting beta-blocker esmolol, given immediately before cardiopulmonary bypass and as a cardioplegia additive, would provide an extra protection to myocardial tissue during cardiopulmonary bypass by virtually reducing myocardial activity and, therefore, oxygen consumption to zero. Materials and methods: This was a single-centre, double-blind, placebo-controlled, parallel-group phase IV trial. Adult patients undergoing elective valvular and non-valvular cardiac surgery with end diastolic diameter >60 mm and ejection fraction <50% were enrolled. Patients were randomly assigned to receive either esmolol, 1 mg/kg before aortic cross-clamping and 2 mg/kg with Custodiol® crystalloid cardioplegia or equivolume placebo. The primary end-point was peak postoperative troponin T concentration. Troponin was measured at Intensive Care Unit arrival and at 4, 24 and 48 hours. Secondary endpoints included ventricular fibrillation after cardioplegic arrest, need for inotropic support and intensive care unit and hospital stay. Results: We found a reduction in peak postoperative troponin T, from 1195 ng/l (690–2730) in the placebo group to 640 ng/l (544–1174) in the esmolol group (p=0.029) with no differences in Intensive Care Unit stay [3 days (1-6) in the placebo group and 3 days (2-5) in the esmolol group] and hospital stay [7 days (6–10) in the placebo group and 7 days (6–12) in the esmolol group]. Troponin peak occurred at 24 hours for 12 patients (26%) and at 4 hours for the others (74%). There were no differences in other secondary end-points. Conclusions: Adding esmolol to the cardioplegia in high-risk patients undergoing elective cardiac surgery reduces peak postoperative troponin levels. Further investigation is necessary to assess esmolol effects on major clinical outcomes.

Diagnostic Value of Cholinesterase Activity for the Development of Postoperative Delirium after Cardiac Surgery

2020 ◽  
Author(s):  
Shekhar Saha ◽  
Kübra Karaca ◽  
Ahmad Fawad Jebran ◽  
Narges Waezi ◽  
Katharina Ort ◽  
...  
Keyword(s):  
Cardiac Surgery ◽  
Intensive Care ◽  
Postoperative Delirium ◽  
Carotid Artery Disease ◽  
Circulatory Arrest ◽  
Diagnostic Value ◽  
Confusion Assessment Method ◽  
Assessment Method ◽  
Elective Cardiac Surgery ◽  
Increased Risk

Abstract Background Depression of cholinesterase (CHE) activity has been reported to lead to an amplified neuroinflammatory response, which clinically manifests as postoperative delirium (PD). This observational study investigates the association between CHE activity and the development of PD following elective cardiac surgery. Methods Patients with preexisting neurologic deficits or carotid artery disease as well as patients undergoing reoperations or procedures under circulatory arrest have been excluded from this study. The Mini-Mental State Examination, the Confusion Assessment Method for the Intensive Care Unit, and the Intensive Care Delirium Screening Checklist were performed at regular intervals. CHE activity was estimated pre- and postoperatively until postoperative day (POD) 5 and at discharge. Results A total of 107 patients were included. PD was diagnosed in 34 (31.8%) patients, who have been compared with those without PD. Time on ventilator, length of ICU, and hospital stay were longer in patients with PD (p = 0.001, p < 0.001, and p = 0.004, respectively). MMSE scores were lower in patients with PD (p < 0.001; p = 0.015). CHE activity on POD 1 to 4 as well as at discharge were lower in the delirium group (p = 0.041; p = 0.029; p = 0.015; p = 0.035; p = 0.028, respectively). A perioperative drop of CHE activity of more than 50% and a postoperative CHE activity below 4,800 U/L (on POD 0) were independently associated with an increased risk of development of PD (p = 0.038; p = 0.008, respectively). Conclusion In addition to the established functional tests, routine estimation of CHE activity may serve as an additional diagnostic tool allowing for the timely diagnosis and treatment of PD in cardiac surgery patients.

scholarly journals I-gel viršgerklinio vamzdelio naudojimas esant sudėtingai endotrachėjinei intubacijai

2011 ◽  
Vol 9 (1-2) ◽  
Author(s):  
Karolis Urbonas ◽  
Robertas Samalavičius
Keyword(s):  
Cardiac Surgery ◽  
Intensive Care ◽  
Pain Management ◽  
Tracheal Intubation ◽  
Difficult Airway ◽  
University Hospital ◽  
Elective Cardiac Surgery ◽  
First Case ◽  
Difficult Airways ◽  
Vilnius University

Karolis Urbonas1, Robertas Samalavičius2 1 II Reanimacijos ir intensyviosios terapijos skyrius, Anesteziologijos, intensyviosios terapijos ir skausmo gydymo centras, Vilniaus universiteto ligoninė Santariškių klinikos,Santariškių g. 2, LT-08661 Vilnius2 II Anesteziologijos ir reanimacijos skyrius, Anesteziologijos, intensyviosios terapijos ir skausmo gydymo centras, Vilniaus universiteto ligoninė Santariškių klinikos,Santariškių g. 2, LT-08661 VilniusEl. paštas: [email protected] Nesėkminga trechėjos intubacija yra reta, tačiau grėsminga komplikacija, ji net gali sukelti mirtį ar hipoksinį smegenų pažeidimą. Užtikrinti ventiliaciją ir oksigenaciją yra nepaprastai svarbu šioje situacijoje. Straipsnyje nagrinėjame du klinikinius sudėtingos intubacijos atvejus ligoniams, kuriems buvo atliekamos planinės kardiochirurginės operacijos. Abiem atvejais nepavykus intubuoti ligonio taikant laringoskopiją, kvėpavimo takų praeinamumas užtikrintas I-gel viršgerkliniu vamzdeliu. Per šį prietaisą pirmajam pacientui fibrobronchoskopu, o antrajam akluoju būdu į trachėją įkištas endotrachėjinis vamzdelis. Aprašyti atvejai rodo, kad ši naujoviška kvėpavimo takų preinamumą užtikrinanti priemonė gali būti sėkmingai taikoma esant sudėtingai intubacijai. Reikšminiai žodžiai: kvėpavimo takai, pasunkėjusi intubacija, viršgerklinis vamzdelis. Intubation through an i-gel supraglottic device in cardiac surgery patients with difficult airway Karolis Urbonas1, Robertas Samalavičius2 1 II Department of Intensive Care, Centre of Anaesthesia, Intensive Care and Pain Management, Vilnius University Hospital Santariškių klinikos, Santariškių Str. 2, LT-08661 Vilnius, Lithuania2 II Department of Anaesthesia, Centre of Anaesthesia, Intensive Care and Pain Management, Vilnius University Hospital Santariškių klinikos, Santariškių Str. 2, LT-08661 Vilnius, LithuaniaE-mail: [email protected] Failed tracheal intubation and prolonged attempts at intubation are the major causes of morbidity or mortality directly associated with anaesthesia. The management of difficult airway and the maintenance of oxygenation are very important. In this article, we present two cases of airway rescue management in patients undergoing elective cardiac surgery. In both cases, the failed tracheal intubation with conventional laryngoscopy was managed with the I-gel, a novel supragllottic device. The mechanical ventilation after insertion of a supraglottic tube was effective. Intubation after visualization of the vocal cords with a fibrobronchoscope through the I-gel in the first case and blind intubation with a tube through the device in the second case were successfully performed. I-gel can be used as an alternative rescue technique in cases of difficult airways. Keywords: airway, difficult intubation, supraglottic device

scholarly journals ΔPCO2 and ΔPCO2/C(a−cv)O2 Are Not Predictive of Organ Dysfunction After Cardiopulmonary Bypass

2021 ◽  
Vol 8 ◽  
Author(s):  
Sheng Zhang ◽  
Dan Zheng ◽  
Xiao-Qiong Chu ◽  
Yong-Po Jiang ◽  
Chun-Guo Wang ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Cardiac Surgery ◽  
Intensive Care ◽  
Cardiopulmonary Bypass ◽  
Organ Dysfunction ◽  
Statistical Significance ◽  
Predictive Performance ◽  
Elective Cardiac Surgery ◽  
Icu Admission ◽  
The Difference

Background: Cardiac surgery is associated with a substantial risk of major adverse events. Although carbon dioxide (CO2)-derived variables such as venous-to-arterial CO2 difference (ΔPCO2), and PCO2 gap to arterial–venous O2 content difference ratio (ΔPCO2/C(a−cv)O2) have been successfully used to predict the prognosis of non-cardiac surgery, their prognostic value after cardiopulmonary bypass (CPB) remains controversial. This hospital-based study explored the relationship between ΔPCO2, ΔPCO2/C(a−cv)O2 and organ dysfunction after CPB.Methods: We prospectively enrolled 114 intensive care unit patients after elective cardiac surgery with CPB. Patients were divided into the organ dysfunction group (OI) and non-organ dysfunction group (n-OI) depending on whether organ dysfunction occurred or not at 48 h after CPB. ΔPCO2 was defined as the difference between central venous and arterial CO2 partial pressure.Results: The OI group has 37 (32.5%) patients, 27 of which (23.7%) had one organ dysfunction and 10 (8.8%) had two or more organ dysfunctions. No statistical significance was found (P = 0.84) for ΔPCO2 in the n-OI group at intensive care unit (ICU) admission (9.0, 7.0–11.0 mmHg), and at 4 (9.0, 7.0–11.0 mmHg), 8 (9.0, 7.0–11.0 mmHg), and 12 h post admission (9.0, 7.0–11.0 mmHg). In the OI group, ΔPCO2 also showed the same trend [ICU admission (9.0, 8.0–12.8 mmHg) and 4 (10.0, 7.0–11.0 mmHg), 8 (10.0, 8.5–12.5 mmHg), and 12 h post admission (9.0, 7.3–11.0 mmHg), P = 0.37]. No statistical difference was found for ΔPCO2/C(a−cv)O2 in the n-OI group (P = 0.46) and OI group (P = 0.39). No difference was detected in ΔPCO2, ΔPCO2/C(a−cv)O2 between groups during the first 12 h after admission (P &gt; 0.05). Subgroup analysis of the patients with two or more failing organs compared to the n-OI group showed that the predictive performance of lactate and Base excess (BE) improved, but not of ΔPCO2 and ΔPCO2/C(a−cv)O2. Regression analysis showed that the BE at 8 h after admission (odds ratio = 1.37, 95%CI: 1.08–1.74, P = 0.009) was a risk factor for organ dysfunction 48 h after CBP.Conclusion : ΔPCO2 and ΔPCO2/C(a−cv)O2 cannot be used as reliable indicators to predict the occurrence of organ dysfunction at 48 h after CBP due to the pathophysiological process that occurs after CBP.

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