Effects of spinal cord injury on osteoblastogenesis, osteoclastogenesis and gene expression profiling in osteoblasts in young rats

2006 ◽  
Vol 18 (3) ◽  
pp. 339-349 ◽  
Author(s):  
S.-D. Jiang ◽  
L.-S. Jiang ◽  
L.-Y. Dai
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Young Rats ◽  
Cord Injury

Gene Expression Profiling Of Skeletal Muscle After Spinal Cord Injury

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S35
Author(s):  
Karen L. Riska ◽  
Yi-Wen Chen ◽  
Patrick Lee ◽  
Francis Lee ◽  
Maria L. Urso ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Cord Injury

Gene Expression Profiling Of Skeletal Muscle After Spinal Cord Injury

2005 ◽  
Vol 37 (Supplement) ◽  
pp. S35
Author(s):  
Karen L. Riska ◽  
Yi-Wen Chen ◽  
Patrick Lee ◽  
Francis Lee ◽  
Maria L. Urso ◽  
...  
Keyword(s):  
Gene Expression ◽  
Skeletal Muscle ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Cord Injury

scholarly journals Paraspinous muscle gene expression profiling following simulated staged endovascular repair of thoracoabdominal aortic aneurysm: exploring potential therapeutic pathways

2019 ◽  
Vol 57 (1) ◽  
pp. 30-38 ◽  
Author(s):  
Erin R Lewis ◽  
Sarah Geisbüsch ◽  
Yun-Juan Chang ◽  
Victor Costa ◽  
Seema Husain ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Aortic Aneurysm ◽  
Gene Expression Profiling ◽  
Expression Profiling ◽  
Thoracoabdominal Aortic Aneurysm ◽  
Cord Injury ◽  
Collateral Network ◽  
Paraspinous Muscle ◽  
Insight Into

Abstract OBJECTIVES Thoracic endovascular techniques for aneurysm repair offer less invasive alternatives to open strategies. Both approaches, however, are associated with the risk for neurological complications. Despite adjuncts to maintain spinal cord perfusion, ischaemia and paraplegia continue to occur during thoracoabdominal aortic aneurysm (TAAA) repair. Staging of such extensive procedures has been proven to decrease the risk for spinal cord injury. Archived biopsy specimens may offer insight into the molecular signature of the reorganization and expansion of the spinal collateral network during staged endovascular interventions in the setting of TAAA. METHODS Biological replicates of total RNA were isolated from existing paraspinous muscle samples from 22 Yorkshire pigs randomized to 1 of 3 simulated TAAA repair strategies as part of a previous study employing coil embolization of spinal segmental arteries within the thoracic and lumbar spine. Gene expression profiling was performed using the Affymetrix GeneChip Porcine array. RESULTS Microarray analysis identified 649 differentially expressed porcine genes (≥1.3-fold change, P ≤ 0.05) when comparing paralysed and non-paralysed subjects. Of these, 355 were available for further analysis. When mapped to the human genome, 169 Homo sapiens orthologues were identified. Integrated interpretation of gene expression profiles indicated the significant regulation of transcriptional regulators (such as nuclear factor кB), cytokine (including CXCL12) elements contributing to hypoxia signalling in the cardiovascular system (vascular endothelial growth factor and UBE2) and cytoskeletal elements (like dystrophin (DMD) and matrix metallopeptidase (MMP)). CONCLUSIONS This study demonstrates the ability of microarray-based platforms to detect the differential expression of genes in paraspinous muscle during staged TAAA repair. Pathway enrichment analysis detected subcellular actors accompanying the neuroprotective effects of staged endovascular coiling. These observations provide new insight into the potential prognostic and therapeutic value of gene expression profiling in monitoring and modulating the arteriolar remodelling in the collateral network.

1134: Gene Expression Profile Changes using CDNA Microarray Technology in Patients with Neurogenic Bladder Secondary to Spinal Cord Injury

2005 ◽  
Vol 173 (4S) ◽  
pp. 308-308
Author(s):  
Jeffrey L. Evans ◽  
Henry Lai ◽  
Mustafa Ozen ◽  
Bhuvaneswari Krishnan ◽  
Michael Ittmann ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Gene Expression Profile ◽  
Neurogenic Bladder ◽  
Cdna Microarray ◽  
Expression Profile ◽  
Microarray Technology ◽  
Cord Injury ◽  
Profile Changes

233-LB: Spinal Cord Injury Inhibited-FGF21 Signaling Is Associated with Dysregulation of Metabolic Gene Expression in Mouse Liver and Adipose Tissue

Diabetes ◽  
2020 ◽  
Vol 69 (Supplement 1) ◽  
pp. 233-LB
Author(s):  
XIN-HUA LIU ◽  
LAUREN HARLOW ◽  
ZACHARY GRAHAM ◽  
JOSHUA F. YARROW ◽  
KENNETH CUSI ◽  
...  
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Adipose Tissue ◽  
Mouse Liver ◽  
Metabolic Gene ◽  
Metabolic Gene Expression ◽  
Cord Injury

scholarly journals Alterations in Mouse Hypothalamic Adipokine Gene Expression and Leptin Signaling following Chronic Spinal Cord Injury and with Advanced Age

PLoS ONE ◽  
2012 ◽  
Vol 7 (7) ◽  
pp. e41073 ◽  
Author(s):  
Gregory E. Bigford ◽  
Valerie C. Bracchi-Ricard ◽  
Mark S. Nash ◽  
John R. Bethea
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Advanced Age ◽  
Chronic Spinal Cord Injury ◽  
Leptin Signaling ◽  
Cord Injury

scholarly journals Elucidation of Gene Expression Patterns in the Brain after Spinal Cord Injury

2017 ◽  
Vol 26 (7) ◽  
pp. 1286-1300 ◽  
Author(s):  
Ahreum Baek ◽  
Sung-Rae Cho ◽  
Sung Hoon Kim
Keyword(s):  
Gene Expression ◽  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Expression Patterns ◽  
Gene Expression Patterns ◽  
Cord Injury ◽  
The Brain

scholarly journals hsa-MiR-19a-3p and hsa-MiR-19b-3p Are Associated with Spinal Cord Injury-Induced Neuropathic Pain: Findings from a Genome-Wide MicroRNA Expression Profiling Screen

2021 ◽  
Vol 2 (1) ◽  
pp. 424-439
Author(s):  
Liang Ye ◽  
Leslie R. Morse ◽  
Scott P. Falci ◽  
Julie K. Olson ◽  
Mayank Shrivastava ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Neuropathic Pain ◽  
Expression Profiling ◽  
Microrna Expression ◽  
Genome Wide ◽  
A Genome ◽  
Cord Injury
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