scholarly journals Differential effects of 5-HTTLPR genotypes on mood, memory, and attention bias following acute tryptophan depletion and stress exposure

2008 ◽  
Vol 203 (4) ◽  
pp. 805-818 ◽  
Author(s):  
Christine Firk ◽  
C. Rob Markus
Keyword(s):  
Attention Bias ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Stress Exposure ◽  
Differential Effects ◽  
Memory And Attention

scholarly journals Effects of lowered serotonin transmission on cocaine-induced striatal dopamine response: PET [11C]raclopride study in humans

2011 ◽  
Vol 199 (5) ◽  
pp. 391-397 ◽  
Author(s):  
Sylvia M. L. Cox ◽  
Chawki Benkelfat ◽  
Alain Dagher ◽  
J. Scott Delaney ◽  
France Durand ◽  
...  
Keyword(s):  
Substance Use ◽  
Substance Use Disorders ◽  
Striatal Dopamine ◽  
Emission Tomography ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Comorbid Conditions ◽  
Drug Craving ◽  
Positron Emission ◽  
Wide Range

BackgroundLow serotonin transmission is thought to increase susceptibility to a wide range of substance use disorders and impulsive traits.AimsTo investigate the effects of lowered serotonin on cocaine-induced (1.0 mg/kg cocaine, self-administered intranasally) dopamine responses and drug craving.MethodIn non-dependent cocaine users, serotonin transmission was reduced using the acute tryptophan depletion method. Striatal dopamine responses were measured using positron emission tomography with [11C]raclopride.ResultsAcute tryptophan depletion increased drug craving and striatal dopamine responses to cocaine. These acute tryptophan depletion-induced increases did not occur in the absence of cocaine.ConclusionsThe results suggest that low serotonin transmission can increase dopaminergic and appetitive responses to cocaine. These findings might identify a mechanism by which individuals with low serotonin are at elevated risk for both substance use disorders and comorbid conditions.

scholarly journals Evaluating the role of serotonin in hot flashes after breast cancer using acute tryptophan depletion

2009 ◽  
Vol 16 (4) ◽  
pp. 644-652 ◽  
Author(s):  
Janet S. Carpenter ◽  
Menggang Yu ◽  
Jingwei Wu ◽  
Diane Von Ah ◽  
Jennifer Milata ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Hot Flashes ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion

B74 THE EFFECTS OF ACUTE TRYPTOPHAN DEPLETION ON BDNF PROTEIN LEVELS IN BRAIN AND SERUM OF MALE AND FEMALE RATS

2005 ◽  
Vol 16 (Supplement 1) ◽  
pp. S89
Author(s):  
E.L. Van Donkelaar ◽  
L.A.W. Jans ◽  
A. Blokland ◽  
N.E.P. Deutz ◽  
G. Kenis ◽  
...  
Keyword(s):  
Female Rats ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Male And Female ◽  
Protein Levels ◽  
Male And Female Rats

scholarly journals Effects of a novel method of acute tryptophan depletion on plasma tryptophan and cognitive performance in healthy volunteers

2004 ◽  
Vol 178 (1) ◽  
pp. 92-99 ◽  
Author(s):  
E. A. T. Evers ◽  
D. E. Tillie ◽  
F. M. van der Veen ◽  
C. K. Lieben ◽  
J. Jolles ◽  
...  
Keyword(s):  
Healthy Volunteers ◽  
Cognitive Performance ◽  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Plasma Tryptophan ◽  
Novel Method

Electrocortical effects of acute tryptophan depletion on emotive facial processing in depression-prone individuals

2010 ◽  
Vol 20 (7) ◽  
pp. 473-486 ◽  
Author(s):  
Natalia Jaworska ◽  
Andrea Thompson ◽  
Dhrasti Shah ◽  
Derek Fisher ◽  
Vadim Ilivitsky ◽  
...  
Keyword(s):  
Acute Tryptophan Depletion ◽  
Tryptophan Depletion ◽  
Facial Processing
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