scholarly journals Safety and Efficacy of Landiolol Hydrochloride in Children with Tachyarrhythmia of Various Etiologies

2021 ◽  
Author(s):  
Atsuko Ashida ◽  
Noriyasu Ozaki ◽  
Kanta Kishi ◽  
Yutaka Odanaka ◽  
Shintaro Nemoto ◽  
...  
Keyword(s):  
Heart Rate ◽  
Sinus Rhythm ◽  
Atrial Tachycardia ◽  
Pediatric Patients ◽  
Heart Rate Response ◽  
Heart Defects ◽  
Perioperative Period ◽  
Junctional Ectopic Tachycardia ◽  
Safety And Efficacy ◽  
Landiolol Hydrochloride

AbstractThe safety and efficacy of landiolol have not been fully elucidated in pediatric patients. This study aimed to clarify the safety and efficacy of landiolol in a pediatric cohort. We retrospectively assessed the clinical features of 21 pediatric patients who were administered landiolol at our hospital. We also investigated the rates of sinus rhythm conversion and heart rate response. The median patient age was 7 months (interquartile range 1–13 months). The etiology of tachyarrhythmia was junctional ectopic tachycardia in 10 patients (47.6%), atrial tachycardia in 10 patients (47.6%), and ventricular tachycardia in 1 patient (4.8%). Of the 21 children, 18 (85.7%) had congenital heart defects, including 14 (77.8%) in whom a landiolol infusion was performed perioperatively. The landiolol infusion was effective in 18 pediatric patients (85.7%), as measured by the conversion to sinus rhythm or a reduced heart rate. Atrial tachycardia in the perioperative period was terminated in all patients. Of 7 patients with tachyarrhythmias unrelated to the perioperative period, landiolol was effective in 5. No adverse effects were reported in any patient. Landiolol infusion is effective and safe in pediatric patients with tachyarrhythmia of various etiologies, especially those with atrial tachyarrhythmia during the perioperative period.

scholarly journals Slow pseudo sinus rhythm and atrial tachycardia of right superior venous pulmonary origin

2021 ◽  
Vol 2021 (10) ◽  
Author(s):  
Thierry Verbeet ◽  
Thomas Nguyen ◽  
Alexandre Almorad ◽  
Maurice Jottrand ◽  
Thierry Wauters ◽  
...  
Keyword(s):  
Heart Rate ◽  
Sinus Rhythm ◽  
Atrial Tachycardia ◽  
P Wave ◽  
Ectopic Activity ◽  
Clear Cut ◽  
Sinus Rate ◽  
Wave Morphology ◽  
The Right ◽  
Atrial Rhythm

ABSTRACT Paroxysmal atrial tachycardia usually presents as a sudden acceleration of the atrial rate combined with modifications of the P wave morphology. A 22-year-old patient presented with very fast and very slow atrial ectopic activity. He complained of repetitive episodes of fast tachycardia, some accompanied with dizziness. When the ectopic discharge was slow, no clear-cut difference between the sinus rate and the ectopic rate was seen and thus the atrial rhythm appeared quite regular. The ectopic focus was situated deep inside the right upper pulmonary vein (RSPV). After RSPV isolation a persistent sinus rhythm was established and since then the patient has been asymptomatic for 3 years. Thus, subtle changes in the P wave morphology without a significant change in the heart rate in patients presenting with palpitations can give a clue to the diagnosis of the tachycardia and the localization of the ectopic focus.

scholarly journals Update on Pediatric non-Postoperative Junctional Ectopic Tachycardia.

2019 ◽  
Vol 2 (3) ◽  
pp. 01-09
Author(s):  
Maldonado Sebastian ◽  
Albaca Guadalupe ◽  
Lafuente María Victoria ◽  
Benjamin Monica ◽  
Lopez Jinete Darues ◽  
...  
Keyword(s):  
Natural History ◽  
Sinus Rhythm ◽  
Treatment Strategy ◽  
Pharmacological Treatment ◽  
Pediatric Patients ◽  
High Morbidity ◽  
Adequate Treatment ◽  
Junctional Ectopic Tachycardia ◽  
History Of ◽  
Multiple Drugs

Junctional ectopic tachycardia (JET) is a rare supraventricular tachycardia more frequently seen in pediatric patients which is associated with high morbidity and mortality without an adequate treatment. Its treatment often requires multiple drugs for arrhythmia control and, in some cases, a cryoablation is indicated. Some patients may revert to sinus rhythm spontaneously after long periods on antiarrhythmic drug. Currently, the arrhythmia prognosis has improved significantly since cryoablation development and the implementation of a more aggressive pharmacological treatment strategy. The purpose of this review is to describe the natural history of idiopathic JET and treatment advances.

scholarly journals Restoring Sinus Rhythm Improves Excessive Heart Rate Response to Exercise in Patients With Atrial Fibrillation.

2003 ◽  
Vol 44 (1) ◽  
pp. 73-82 ◽  
Author(s):  
Zerrin Yigit ◽  
Hülya Akdur ◽  
Ümit Arabaci ◽  
Hülya Nilgün Gürses ◽  
Deniz Güzelsoy
Keyword(s):  
Atrial Fibrillation ◽  
Heart Rate ◽  
Sinus Rhythm ◽  
Heart Rate Response ◽  
Response To Exercise

scholarly journals The experience of radiofrequency ablation of atrial tachycardia focus with the use of high-density myocardial mapping

2019 ◽  
Vol 100 (2) ◽  
pp. 340-344
Author(s):  
A S Omelyanenko ◽  
T I Mavlyudov ◽  
O V Sapelnikov ◽  
D I Cherkashin ◽  
I M Islamova ◽  
...  
Keyword(s):  
Heart Rate ◽  
Radiofrequency Ablation ◽  
High Resolution ◽  
Sinus Rhythm ◽  
Navigation System ◽  
Atrial Tachycardia ◽  
High Density ◽  
Radiation Load ◽  
Focal Atrial Tachycardia ◽  
Electrophysiological Examination

The article presents a case of successful treatment of focal atrial tachycardia by radiofrequency ablation using high-density myocardial mapping. The aim of the work was to evaluate the possibilities of high-resolution myocardial mapping by EnsitePrecision® navigation system in the treatment of complex arrhythmias. The analysis of clinical data and results of electrophysiological examination of a 29-year-old patient with continuous recurrent focal atrial tachycardia was carried out. The patient was admitted with complaints of heart rate disorders and frequent short attacks of palpitations. According to electrocardiography, frequent short paroxysms of focal atrial tachycardia were revealed. The patient was taken for electrophysiological examination and radiofrequency ablation of the focus of atrial tachycardia. The focus of atrial tachycardia was located in the anterior septal part of the left atrium, which is a rare localization. After radiofrequency ablation tachycardia was terminated, no complications and recurrences were registered. The patient was discharged with the sinus rhythm. Navigation system EnsitePrecision® enables conducting high-density myocardial mapping, which helps to accurately determine the localization of the source of tachycardia. The radiation load on the patient and ablation time are reduced, which reduces the frequency of complications from the procedure.

scholarly journals Experience in the management of infants with multifocal atrial tachycardia

2021 ◽  
Vol 28 (4) ◽  
pp. 24-33
Author(s):  
T. S. Kovalchuk ◽  
T. K. Kruchina ◽  
R. B. Tatarskiy ◽  
T. M. Pervunina ◽  
M. Sh. Malyarova ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Disease ◽  
Sinus Rhythm ◽  
Atrial Tachycardia ◽  
Structural Heart Disease ◽  
Good Prognosis ◽  
Term Selection ◽  
Selection Of

Purpose. To study the clinical course of multifocal atrial tachycardia (MAT) and to evaluate the effectiveness of antiarrhythmic therapy (AAT) in patients with onset of arrhythmia before the age of 1 year.Methods. The study included 15 children with primary registration of MAT at the age of 2.04±2.27 months, 4 of them - in utero. The follow-up period was 35.9±26.9 months (Me 29 months). All patients underwent laboratory monitoring, 12-lead ECG recording, 24-hour ECG monitoring, echocardiography at baseline and during time of observation.Results. Tachycardia was persistent in 80% of patients. Tachycardia-induced cardiomyopathy (TIC) was present in 7 (46%) patients. Structural heart disease was detected in 6 patients. The average heart rate at the onset of the disease was 157.9±23.78 bpm, the maximum - 256.7±35.84 bpm. Fourteen (93.3%) children received AAT. Seven patients were prescribed propranolol first, 6 - amiodarone, 1 - digoxin. Monotherapy was effective in 2 patients. Combined AAT was used in 12 patients, including three children with three drugs combination. No benefits were found for any of the drugs combinations. Stable sinus rhythm at the time of discharge was observed in 4 (28,6%) patients, sinus rhythm with atrial ectopic activity was registered in 2 of them; criteria for normosystole were achieved in 7 patients; in one child with TIC daytime tachysystole persisted despite three-component AAT, but echocardiography parameters improved. Arrhythmia was disappeared in 13 (86.6%) patients; the duration of arrhythmia in them from 1 to 15 months, duration of AAT - 1 ±7.5 months (Me 9.5 months). MAT persists in two patients with structural heart disease. One patient underwent radiofrequency ablation at the age of 5, with no effect. One patient had side effects from therapy that required correction. There were no lethal outcomes.Conclusion. MAT with a debut at the age of 1 year with timely prescribed treatment has a favorable course and a good prognosis, but the probability of AAT resistance is high. These cases require a long-term selection of therapy using various combinations of antiarrhythmic drugs. Heart rate control strategy can be sufficient to prevent the development of TIC.

The discriminative control of a conditioned heart rate response.

1957 ◽  
Author(s):  
Philip J. Bersh ◽  
Joseph M. Notterman ◽  
William N. Schoenfeld
Keyword(s):  
Heart Rate ◽  
Heart Rate Response ◽  
Discriminative Control ◽  
Conditioned Heart Rate
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