scholarly journals High-resolution three‑dimensional contrast‑enhanced magnetic resonance venography in children: comparison of gadofosveset trisodium with ferumoxytol

2021 ◽  
Author(s):  
Puja Shahrouki ◽  
Sarah N. Khan ◽  
Takegawa Yoshida ◽  
Paul J. Iskander ◽  
Shahnaz Ghahremani ◽  
...  
Keyword(s):  
High Resolution ◽  
Image Quality ◽  
Contrast Agent ◽  
Adverse Reactions ◽  
Interobserver Agreement ◽  
Three Dimensional ◽  
Vena Cava ◽  
Blood Pool ◽  
Mr Venography ◽  
Venous Signal

Abstract Background Gadofosveset is a gadolinium-based blood pool contrast agent that was approved by the United States Food and Drug Administration in 2008. Its unanticipated withdrawal from production in 2016 created a void in the blood pool agent inventory and highlighted the need for an alternative agent with comparable imaging properties. Objective The purpose of our study is to compare the diagnostic image quality, vascular contrast-to-noise ratio (CNR) and temporal signal characteristics of gadofosveset trisodium and ferumoxytol at similar molar doses for high-resolution, three-dimensional (3-D) magnetic resonance (MR) venography in children. Materials and methods The medical records and imaging data sets of patients who underwent high-resolution 3-D gadofosveset-enhanced MR venography (GE-MRV) or ferumoxytol-enhanced MR venography (FE-MRV) were retrospectively reviewed. Two groups of 20 pediatric patients (age- and weight-matched with one patient common to both groups; age range: 2 days–15 years) who underwent high-resolution 3-D GE-MRV or FE-MRV at similar molar doses were identified and analyzed. Qualitative analysis of image quality and vessel definition was performed by two blinded pediatric radiologists. Interobserver agreement was assessed with the AC1 (first-order agreement coefficient) statistic. Signal-to-noise ratio (SNR) and CNR of the inferior vena cava and aorta were measured in the steady-state venous phase. Medical records were retrospectively reviewed for any adverse reactions associated with either contrast agent. Results Measured SNR and CNR of the inferior vena cava were higher for FE-MRV than GE-MRV (P = 0.034 and P < 0.001, respectively). The overall image quality score and individual vessel scores of FE-MRV were equal to or greater than GE-MRV (P = 0.084), with good interobserver agreement (AC1 = 0.657). The venous signal on FE-MRV was stable over the longest interval measured (1 h, 13 min and 46 s), whereas venous signal on GE-MRV showed more variability and earlier loss of signal. No adverse reactions were noted in any patient with either contrast agent. Conclusion Ferumoxytol produces more uniform and stable enhancement throughout the entire venous circulation in children than gadofosveset, offering a wider time window for optimal image acquisition. FE-MRV offers a near-ideal approach to high-resolution venography in children at all levels of anatomical complexity.

Three-dimensional navigator coronary MRA with the aid of a blood pool agent in pigs: Improved image quality with inclusion of the contrast agent first-pass

2003 ◽  
Vol 18 (4) ◽  
pp. 502-506 ◽  
Author(s):  
Martijn S. Dirksen ◽  
Theodorus A.M. Kaandorp ◽  
Hildo J. Lamb ◽  
J. Doornbos ◽  
Claire Corot ◽  
...  
Keyword(s):  
Image Quality ◽  
Contrast Agent ◽  
Three Dimensional ◽  
Blood Pool ◽  
Blood Pool Agent ◽  
Coronary Mra ◽  
First Pass

Interobserver agreement and image quality of functional cardiac ultrasound measures used in a randomised trial of delayed cord clamping in preterm infants

2017 ◽  
Vol 103 (3) ◽  
pp. F257-F263 ◽  
Author(s):  
Himanshu Popat ◽  
Kristy P Robledo ◽  
Lucille Sebastian ◽  
Nicholas Evans ◽  
Andrew Gill ◽  
...  
Keyword(s):  
Image Quality ◽  
Preterm Infants ◽  
Interobserver Agreement ◽  
Ductus Arteriosus ◽  
Randomised Trial ◽  
Vena Cava ◽  
Mean Difference ◽  
Cardiac Ultrasound ◽  
Delayed Cord Clamping ◽  
Cord Clamping

ObjectiveFunctional cardiac ultrasound measures are used clinically and in trials for assessing the haemodynamic status of newborn infants. Superior vena cava (SVC) flow and right ventricular output (RVO) are established measures of systemic blood flow on the first postnatal day. The objective was to assess image quality and interobserver agreement of these measures in preterm infants enrolled in a randomised trial of immediate versus delayed cord clamping.Design and settingImage quality and interobserver agreement for SVC flow, RVO and ductus arteriosus (DA) size were assessed on measurements taken at 3–6, 6–12 and 20–28 hours for the first 10 infants enrolled at each of four sites (total 40). Bland-Altman plots were constructed; mean difference (bias) and limits of agreement (LOA) were calculated. Potential sources of variation were explored.ResultsQuality was judged satisfactory for >97% of images. The mean difference and LOA between the observers were 5.4 mL/kg/min and −49.0 to 59.8 mL/kg/min for SVC flow, −26.6 mL/kg/min and −131.4 to 78.2 mL/kg/min for RVO, and 0 mm and −0.8 to 0.8 mm for DA diameter, respectively. The principal source of measurement error for SVC flow was diameter, and for RVO, diameter and velocity time integral. The difference between observers for both SVC and RVO was significantly associated with site.ConclusionInterobserver variability for SVC flow is consistent with that previously reported, but higher for RVO. The findings should be incorporated into clinical practice, training, accreditation and trial design.

scholarly journals 3D Dixon water-fat LGE imaging with image navigator and compressed sensing in cardiac MRI

2020 ◽  
Author(s):  
Martin Georg Zeilinger ◽  
Marco Wiesmüller ◽  
Christoph Forman ◽  
Michaela Schmidt ◽  
Camila Munoz ◽  
...  
Keyword(s):  
High Resolution ◽  
Image Quality ◽  
Compressed Sensing ◽  
Cardiac Mri ◽  
Three Dimensional ◽  
Fat Suppression ◽  
Diagnostic Confidence ◽  
Pericardial Disease ◽  
Scan Time ◽  
Wilcoxon Rank Sum Test

Abstract Objectives To evaluate an image-navigated isotropic high-resolution 3D late gadolinium enhancement (LGE) prototype sequence with compressed sensing and Dixon water-fat separation in a clinical routine setting. Material and methods Forty consecutive patients scheduled for cardiac MRI were enrolled prospectively and examined with 1.5 T MRI. Overall subjective image quality, LGE pattern and extent, diagnostic confidence for detection of LGE, and scan time were evaluated and compared to standard 2D LGE imaging. Robustness of Dixon fat suppression was evaluated for 3D Dixon LGE imaging. For statistical analysis, the non-parametric Wilcoxon rank sum test was performed. Results LGE was rated as ischemic in 9 patients and non-ischemic in 11 patients while it was absent in 20 patients. Image quality and diagnostic confidence were comparable between both techniques (p = 0.67 and p = 0.66, respectively). LGE extent with respect to segmental or transmural myocardial enhancement was identical between 2D and 3D (water-only and in-phase). LGE size was comparable (3D 8.4 ± 7.2 g, 2D 8.7 ± 7.3 g, p = 0.19). Good or excellent fat suppression was achieved in 93% of the 3D LGE datasets. In 6 patients with pericarditis, the 3D sequence with Dixon fat suppression allowed for a better detection of pericardial LGE. Scan duration was significantly longer for 3D imaging (2D median 9:32 min vs. 3D median 10:46 min, p = 0.001). Conclusion The 3D LGE sequence provides comparable LGE detection compared to 2D imaging and seems to be superior in evaluating the extent of pericardial involvement in patients suspected with pericarditis due to the robust Dixon fat suppression. Key Points • Three-dimensional LGE imaging provides high-resolution detection of myocardial scarring. • Robust Dixon water-fat separation aids in the assessment of pericardial disease. • The 2D image navigator technique enables 100% respiratory scan efficacy and permits predictable scan times.

scholarly journals Three-dimensional MR pulmonary perfusion imaging and angiography with an injection of a new blood pool contrast agent B-22956/1

2001 ◽  
Vol 14 (4) ◽  
pp. 425-432 ◽  
Author(s):  
Jie Zheng ◽  
James Carr ◽  
Katherine Harris ◽  
Mark B. Saker ◽  
Friedrich M. Cavagna ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Perfusion Imaging ◽  
Three Dimensional ◽  
Blood Pool ◽  
Pulmonary Perfusion ◽  
Blood Pool Contrast Agent

scholarly journals PEG-modified gadolinium nanoparticles as contrast agents for in vivo micro-CT

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Charmainne Cruje ◽  
P. Joy Dunmore-Buyze ◽  
Eric Grolman ◽  
David W. Holdsworth ◽  
Elizabeth R. Gillies ◽  
...  
Keyword(s):  
Contrast Agent ◽  
Contrast Agents ◽  
Soft Tissues ◽  
Three Dimensional ◽  
Blood Pool ◽  
Micro Ct ◽  
Micro Computed Tomography ◽  
Poly Ethylene

AbstractVascular research is largely performed in rodents with the goal of developing treatments for human disease. Micro-computed tomography (micro-CT) provides non-destructive three-dimensional imaging that can be used to study the vasculature of rodents. However, to distinguish vasculature from other soft tissues, long-circulating contrast agents are required. In this study, we demonstrated that poly(ethylene glycol) (PEG)-coated gadolinium nanoparticles can be used as a vascular contrast agent in micro-CT. The coated particles could be lyophilized and then redispersed in an aqueous solution to achieve 100 mg/mL of gadolinium. After an intravenous injection of the contrast agent into mice, micro-CT scans showed blood pool contrast enhancements of at least 200 HU for 30 min. Imaging and quantitative analysis of gadolinium in tissues showed the presence of contrast agent in clearance organs including the liver and spleen and very low amounts in other organs. In vitro cell culture experiments, subcutaneous injections, and analysis of mouse body weight suggested that the agents exhibited low toxicity. Histological analysis of tissues 5 days after injection of the contrast agent showed cytotoxicity in the spleen, but no abnormalities were observed in the liver, lungs, kidneys, and bladder.

scholarly journals High-resolution magnetic resonance angiography in the mouse using a nanoparticle blood-pool contrast agent

2009 ◽  
Vol 62 (6) ◽  
pp. 1447-1456 ◽  
Author(s):  
Gabriel P. Howles ◽  
Ketan B. Ghaghada ◽  
Yi Qi ◽  
Srinivasan Mukundan ◽  
G. Allan Johnson
Keyword(s):  
Magnetic Resonance ◽  
High Resolution ◽  
Magnetic Resonance Angiography ◽  
Contrast Agent ◽  
Blood Pool ◽  
Blood Pool Contrast Agent
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