scholarly journals Imaging coronary plaques using 3D motion-compensated [18F]NaF PET/MR

2021 ◽  
Author(s):  
Johannes Mayer ◽  
Thomas-Heinrich Wurster ◽  
Tobias Schaeffter ◽  
Ulf Landmesser ◽  
Andreas Morguet ◽  
...  
Keyword(s):  
Attenuation Correction ◽  
Free Breathing ◽  
Cardiac Motion ◽  
Water Fraction ◽  
3 Dimensional ◽  
Background Ratio ◽  
Motion Models ◽  
Physiological Motion ◽  
Atherosclerosis Imaging ◽  
Novel Applications

Abstract Background Cardiac PET has recently found novel applications in coronary atherosclerosis imaging using [18F]NaF as a radiotracer, highlighting vulnerable plaques. However, the resulting uptakes are relatively small, and cardiac motion and respiration-induced movement of the heart can impair the reconstructed images due to motion blurring and attenuation correction mismatches. This study aimed to apply an MR-based motion compensation framework to [18F]NaF data yielding high-resolution motion-compensated PET and MR images. Methods Free-breathing 3-dimensional Dixon MR data were acquired, retrospectively binned into multiple respiratory and cardiac motion states, and split into fat and water fraction using a model-based reconstruction framework. From the dynamic MR reconstructions, both a non-rigid cardiorespiratory motion model and a motion-resolved attenuation map were generated and applied to the PET data to improve image quality. The approach was tested in 10 patients and focal tracer hotspots were evaluated concerning their target-to-background ratio, contrast-to-background ratio, and their diameter. Results MR-based motion models were successfully applied to compensate for physiological motion in both PET and MR. Target-to-background ratios of identified plaques improved by 7 ± 7%, contrast-to-background ratios by 26 ± 38%, and the plaque diameter decreased by −22 ± 18%. MR-based dynamic attenuation correction strongly reduced attenuation correction artefacts and was not affected by stent-related signal voids in the underlying MR reconstructions. Conclusions The MR-based motion correction framework presented here can improve the target-to-background, contrast-to-background, and width of focal tracer hotspots in the coronary system. The dynamic attenuation correction could effectively mitigate the risk of attenuation correction artefacts in the coronaries at the lung-soft tissue boundary. In combination, this could enable a more reproducible and reliable plaque localisation.

scholarly journals Anatomic Evaluation of 3-Dimensional Ultrashort-Echo-Time Bone Maps for PET/MR Attenuation Correction

2014 ◽  
Vol 55 (5) ◽  
pp. 780-785 ◽  
Author(s):  
G. Delso ◽  
M. Carl ◽  
F. Wiesinger ◽  
L. Sacolick ◽  
M. Porto ◽  
...  
Keyword(s):  
Attenuation Correction ◽  
Ultrashort Echo Time ◽  
3 Dimensional ◽  
Echo Time

scholarly journals Unsupervised free-breathing 3-dimensional imaging of morphology, function and flow in congenital heart disease under 30 minutes: pilot study

2014 ◽  
Vol 16 (S1) ◽  
Author(s):  
Rajesh Krishnamurthy ◽  
Ramkumar Krishnamurthy ◽  
Elijah Bolin ◽  
LaDonna Malone ◽  
Myriam E Almeida-Jones ◽  
...  
Keyword(s):  
Congenital Heart Disease ◽  
Heart Disease ◽  
Pilot Study ◽  
Congenital Heart ◽  
Free Breathing ◽  
3 Dimensional

scholarly journals Effect of Time-of-Flight Information on PET/MR Reconstruction Artifacts: Comparison of Free-breathing versus Breath-hold MR-based Attenuation Correction

Radiology ◽  
2017 ◽  
Vol 282 (1) ◽  
pp. 229-235 ◽  
Author(s):  
Gaspar Delso ◽  
Mohammed Khalighi ◽  
Edwin ter Voert ◽  
Felipe Barbosa ◽  
Tetsuro Sekine ◽  
...  
Keyword(s):  
Attenuation Correction ◽  
Time Of Flight ◽  
Free Breathing ◽  
Breath Hold ◽  
Mr Reconstruction

scholarly journals Effect of Attenuation Correction on Regional Quantification Between PET/MR and PET/CT: A Multicenter Study Using a 3-Dimensional Brain Phantom

2016 ◽  
Vol 57 (5) ◽  
pp. 818-824 ◽  
Author(s):  
J. Teuho ◽  
J. Johansson ◽  
J. Linden ◽  
A. E. Hansen ◽  
S. Holm ◽  
...  
Keyword(s):  
Attenuation Correction ◽  
Multicenter Study ◽  
3 Dimensional ◽  
Pet Ct ◽  
Brain Phantom

Effect Of Nickel In Large Grain Poly-Si Film Formed By Nickel Induced Lateral Crystallization and New Grain Enhancement Method

2000 ◽  
Vol 609 ◽  
Author(s):  
W.Y. Chan ◽  
A.M. Myasnikov ◽  
M.C. Poon ◽  
C.Y. Yuen ◽  
P. G. Han ◽  
...  
Keyword(s):  
Low Cost ◽  
Silicon Film ◽  
Silicon On Insulator ◽  
3 Dimensional ◽  
Enhancement Method ◽  
Novel Method ◽  
Amorphous Si ◽  
Lateral Crystallization ◽  
Novel Applications ◽  
Soi Substrates

ABSTRACTLarge grain poly-silicon film (poly-Si) with high material quality and uniformity can have numerous novel applications such as providing a low cost alternative to form silicon-on-insulator (SOI) substrates and a breakthrough technology to ultra-dense 3-dimensional multi-layer SOI like devices and circuits. Nickel Induced Lateral Crystallization (NILC) of amorphous Si (a-Si) has been studied intensively, yet the grains are still small (∼ 1 μm). Recently, we have reported a novel method by combining NILC and a new annealing (at above 900 °C) to form poly-Si film with very large grains ranging from 10 μm to 100 μm. The film has good quality and the TFTs formed are highly comparable to SOI TFTs. This work further reports the effect of Ni to the new large-grain poly-Si film.

Abstract 2334: Head-to-head Comparison of Whole-Heart Coronary MR and 40/64 slice Multidetector-CT Angiography for Detection of Coronary Artery Stenosis.

Circulation ◽  
2007 ◽  
Vol 116 (suppl_16) ◽  
Author(s):  
Anne-Catherine Pouleur ◽  
Jean-Benoit le Polain de Waroux ◽  
Joelle Kefer ◽  
Céline Goffinet ◽  
Jean-Louis Vanoverschelde ◽  
...  
Keyword(s):  
Diagnostic Accuracy ◽  
Cardiac Catheterization ◽  
Multidetector Ct ◽  
Reference Method ◽  
Free Breathing ◽  
Luminal Diameter ◽  
3 Dimensional ◽  
Coronary Imaging ◽  
Coronary Stenoses ◽  
Whole Heart

Purpose . Whole-heart magnetic resonance coronary angiography (WH-MRCA) has been recently proposed for non-invasive coronary imaging. Early studies have suggested that WH-MRCA might have similarly high diagnostic accuracy for detection of coronary disease as multidetector CT (MDCT). Yet, no direct comparison between both techniques has been performed. The aim of the present study was therefore to perform a head-to-head comparison of both techniques for detection of significant coronary stenoses using invasive cardiac catheterization as reference standard. Methods. Seventy-seven consecutive patients (56 M, 61±14 years) prospectively underwent free-breathing 3-dimensional WH-MRCA and 40/64-slice MDCT before cardiac catheterization. WH-MRCA and MDCT images were visually graded by 2 blinded observers and the diagnostic accuracy of both methods for detecting >50% luminal diameter stenoses (DS) in segments and vessels >1.5 mm size was compared using quantitative angiography (QCA) as reference method. Results. MDCT was successfully completed in all 77 patients in < 5 minutes. By contrast, WH-MRCA failed in 9 patients (12%) because of poor navigator performance and lasted 20±4 minutes (p<.01 vs MDCT). According to QCA, out of 992 segments > 1.5 mm diameter, 49 presented >50% DS. If all segments including non interpretable segments were considered, WH-MRCA had lower sensibility (35/49 or 71% vs. 45/49 or 92%, p<0.001), lower specificity (644/943 or 68% vs. 863/943 or 92%, p<0.001) and accuracy (679/992 or 68% vs. 908/992 or 92%, p<0.001) for detection of coronary stenosis than MDCT. However if only interpretable segments were considered, the sensitivity (35/37 or 95% vs. 45/46 or 98%, p=0.58), specificity (644/689 or 93% vs. 863/917 or 94%, p=0.67) and diagnostic accuracy (679/726 or 94%, vs. 908/963 or 94%, p=0.58) of WH-MRCA and MDCT for detection of >50% DS was similar. This was also the case on per-vessel basis. Conclusion. In the present study, MDCT had higher success rate than WH-MRCA. Therefore on an intention to diagnose basis, MDCT was superior to WH-MRCA. However, the diagnostic accuracy of WH-MRCA on per-segment and per-vessel basis was not statistically different from MDCT if only interpretable segments were considered.

scholarly journals Blind Compressed Sensing Enables 3-Dimensional Dynamic Free Breathing Magnetic Resonance Imaging of Lung Volumes and Diaphragm Motion

2016 ◽  
Vol 51 (6) ◽  
pp. 387-399 ◽  
Author(s):  
Sampada Bhave ◽  
Sajan Goud Lingala ◽  
John D. Newell ◽  
Scott K. Nagle ◽  
Mathews Jacob
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Compressed Sensing ◽  
Free Breathing ◽  
Resonance Imaging ◽  
Lung Volumes ◽  
3 Dimensional ◽  
Diaphragm Motion
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