scholarly journals Breast and Tumour Volume Measurements in Breast Cancer Patients Using 3-D Automated Breast Volume Scanner Images

2018 ◽  
Vol 42 (7) ◽  
pp. 2087-2093 ◽  
Author(s):  
M. Lagendijk ◽  
E. L. Vos ◽  
K. P. Ramlakhan ◽  
C. Verhoef ◽  
A. H. J. Koning ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Tumour Volume ◽  
Breast Volume ◽  
Breast Cancer Patients ◽  
Automated Breast Volume Scanner ◽  
Volume Measurements

Perceived stress to predict for acute radiation-induced skin toxicity: The mind-body connection.

2013 ◽  
Vol 31 (26_suppl) ◽  
pp. 62-62
Author(s):  
Bree Ruppert Eaton ◽  
Tian Liu ◽  
Xiaofeng Yang ◽  
Donna Mister ◽  
Yize Zhao ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Perceived Stress ◽  
Univariate Analysis ◽  
High Stress ◽  
Skin Toxicity ◽  
Skin Thickness ◽  
Breast Volume ◽  
Breast Cancer Patients ◽  
Acute Skin Toxicity

62 Background: Previous studies have reported that breast cancer patients with high stress levels at diagnosis develop more frequent and severe side effects of chemotherapy treatment. However, the relationship between stress and radiotherapy (RT) related treatment toxicity has not been evaluated. We investigated whether baseline stress is associated with worse acute skin toxicity in women undergoing breast RT. Methods: Between March 2010 and April 2013, 80 post-lumpectomy breast cancer patients were enrolled on a prospective study prior to undergoing definitive whole breast RT (50 Gy plus a 10 Gy boost). Prior to RT (baseline), at week 6 of RT (T2), and 6 weeks post RT (T3), subjects completed the Perceived Stress Scale (PSS) and underwent objective ultrasound measurements of epidermal thickness over the lumpectomy cavity and in all four quadrants of the treated breast. A skin thickness ratio (STRA) was generated by normalizing for measurements taken of the untreated breast. RT-induced skin toxicity was assessed by measuring the change in STRA from baseline to T2 and T3. Results: Mean STRA increased by 23% (SD 27%) and 33% (SD 25%) from baseline to T2 and T3, respectively. Univariate analysis revealed PSS score at baseline (p=.04), body mass index (p=.03), maximum RT dose (Dmax) (p=.02) and whole breast volume (p<.001) were significantly associated with increased changes in STRA during RT. Depression, fatigue, race, chemotherapy, patient age, and tumor stage were not associated with changes in STRA. On multivariate analysis, PSS (p=.05), breast volume (p=.004), and Caucasian race (p=.04) were associated with greater acute changes in STRA from baseline to T2. Breast volume (p=.01), but not PSS, predicted for greater changes in STRA 6 weeks after RT was completed. Conclusions: In women with breast cancer, a high level of perceived stress prior to RT is associated with more severe acute skin toxicity during RT but not after RT is completed. Strategies to reduce stress prior to RT may improve tolerance of treatment.

scholarly journals Risk Factors Related to Acute Radiation Dermatitis in Breast Cancer Patients After Radiotherapy: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Yuxiu Xie ◽  
Qiong Wang ◽  
Ting Hu ◽  
Renwang Chen ◽  
Jue Wang ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Cancer Patients ◽  
Study Design ◽  
Meta Analysis ◽  
Radiation Dermatitis ◽  
Breast Volume ◽  
Breast Cancer Patients ◽  
Related Risk ◽  
Sequential Boost

BackgroundAcute radiation dermatitis (ARD) is the most common acute response after adjuvant radiotherapy in breast cancer patients and negatively affects patients’ quality of life. Some studies have reported several risk factors that can predict breast cancer patients who are at a high risk of ARD. This study aimed to identify patient- and treatment-related risk factors associated with ARD.MethodsPubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, and WanFang literature databases were searched for studies exploring the risk factors in breast cancer patients. The pooled effect sizes, relative risks (RRs), and 95% CIs were calculated using the random-effects model. Potential heterogeneity and sensitivity analyses by study design, ARD evaluation scale, and regions were also performed.ResultsA total of 38 studies composed of 15,623 breast cancer patients were included in the analysis. Of the seven available patient-related risk factors, four factors were significantly associated with ARD: body mass index (BMI) ≥25 kg/m2 (RR = 1.11, 95% CI = 1.06–1.16, I2 = 57.1%), large breast volume (RR = 1.02, 95% CI = 1.01–1.03, I2 = 93.2%), smoking habits (RR = 1.70, 95% CI = 1.24–2.34, I2 = 50.7%), and diabetes (RR = 2.24, 95% CI = 1.53–3.27, I2 = 0%). Of the seven treatment-related risk factors, we found that hypofractionated radiotherapy reduced the risk of ARD in patients with breast cancer compared with that in conventional fractionated radiotherapy (RR = 0.28, 95% CI = 0.19–0.43, I2 = 84.5%). Sequential boost and bolus use was significantly associated with ARD (boost, RR = 1.91, 95% CI = 1.34–2.72, I2 = 92.5%; bolus, RR = 1.94, 95% CI = 1.82–4.76, I2 = 23.8%). However, chemotherapy regimen (RR = 1.17, 95% CI = 0.95–1.45, I2 = 57.2%), hormone therapy (RR = 1.35, 95% CI = 0.94–1.93, I2 = 77.1%), trastuzumab therapy (RR = 1.56, 95% CI = 0.18–1.76, I2 = 91.9%), and nodal irradiation (RR = 1.57, 95% CI = 0.98–2.53, I2 = 72.5%) were not correlated with ARD. Sensitivity analysis results showed that BMI was consistently associated with ARD, while smoking, breast volume, and boost administration were associated with ARD depending on study design, country of study, and toxicity evaluation scale used. Hypofractionation was consistently shown as protective. The differences between study design, toxicity evaluation scale, and regions might explain a little of the sources of heterogeneity.ConclusionThe results of this systematic review and meta-analysis indicated that BMI ≥ 25 kg/m2 was a significant predictor of ARD and that hypofractionation was consistently protective. Depending on country of study, study design, and toxicity scale used, breast volume, smoking habit, diabetes, and sequential boost and bolus use were also predictive of ARD.

A Comparative Study between Round Block Technique and Standard Wide Local Excision in Breast Cancer Patients

QJM ◽  
2021 ◽  
Vol 114 (Supplement_1) ◽  
Author(s):  
Amr Abd El-Raouf Ali Abd El-Naser ◽  
Dina Hany Ahmed ◽  
Mohamed Shawky Mohamed
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Local Excision ◽  
Surgical Outcomes ◽  
Wide Local Excision ◽  
Breast Volume ◽  
Breast Cancer Patients ◽  
Oncological Safety ◽  
Patients Satisfaction ◽  
Areola Complex

Abstract Background The goal of optimizing the cosmetic and oncologic outcomes of BCS has been addressed in recent years by the emergence of the field of oncoplastic surgery, that originally defined as an assortment of volume replacement techniques performed by plastic surgeons to replace all or part of the resected breast volume with myocutaneous tissue flaps. The definition of oncoplastic surgery has more recently been expanded to include a wide range of volume displacement or volume redistribution procedures performed by breast surgeons and general surgeons to optimize breast shape and breast volume following breast cancer surgery. Aim of the Work To assess the round block technique as regard oncological safety, surgical outcomes and patients' satisfaction comparing results with standard wide local excision. Patients and Methods This is a prospective randomized study to assess the round block technique as an oncological procedure for management of early breast cancer near to nipple-areola complex as regard oncological safety, surgical outcomes and patients' satisfaction comparing results with standard wide local excision. Twenty breast cancer patients are subdivided into group (A) 10 females which underwent round block technique and group (B) 10 femaleswhich underwent standard wide local excision. Patient and tumor criteria including age, co morbidities, tumor size and distance between tumor and nipple-areola complex were considered to be non-significant between 2 groups so the only difference is the surgical technique. Results The round block technique and SWLE have the same results regarding operative time, intra-operative blood loss and post operative complications with the advantage to RBT because of its better cosmetic outcomes and lower re-excision rates. So, the round block technique is superior to SWLE in selected cases. Conclusion The round block technique has comparable operative parameters to SWLE with no evidence of increased surgical complications. With a lower re-excision rates and better cosmoses were observed in the round block patients as it is scarless operation without nipple and areola shift suggesting that the round block technique is superior to SWLE in selected cases.

Initiating a lymphedema screening program for breast cancer patients: Determining variability as a first step towards standardization.

2016 ◽  
Vol 34 (7_suppl) ◽  
pp. 267-267
Author(s):  
Simona Flora Shaitelman ◽  
Susan E Ferguson ◽  
Sarah Marie DeSnyder ◽  
Parviz Kheirkhah ◽  
Susan Lilly ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Screening Program ◽  
Volume Measurement ◽  
Analysis Tool ◽  
Breast Cancer Patients ◽  
Targeted Interventions ◽  
Volume Measurements ◽  
Total Variability ◽  
Rater Variability

267 Background: Breast cancer-related lymphedema (BCRL) is a known morbidity from treatment, and yet published estimates of its incidence are highly variable. Typically, a single volume measurement is recorded and the degree of intra-rater variability undefined. A threshold 5% limb volume change over time is used to define “mild lymphedema.” Therefore, small variations in volume measurements could substantially lead to over or under-diagnosis of BRCL. Gage R&R is a measurement systems analysis tool that quantifies the amount of variability induced in measurements by the measurement system itself and compares this to the total variability observed. The objective of this study was to define the degree of variability in perometer arm volume measurements and factors contributing to this. Methods: A medical assistant (MA) was trained by a certified lymphedema therapist (CLT) to perform perometer-based lymphedema screening in the MD Anderson Nellie B. Connally Breast Center. Three measurements of each arm were taken and intra-rater variability against the mean calculated. Gage R&R testing was performed by the MA and CLT, to determine the degree of repeatability and reproducibility variation. As a part of this analysis, 30 patients had both their left and right arm volume measured 3 times by each measurer. Results: Over 6 months, 565 breast cancer patients had preoperative BCRL screening by the MA, with an overall intra-rater variability of 2.2%. Among the 30 patients in the Gage R&R study, median body mass index (BMI) was 27.7 (range 19.7-38.3), median height 1.61m (range 1.52-1.73m), intrarater variability of the MA was 2.07% and of the CLT was 1.21%. Gage R&R accounted for 4.77% of total variability, 1.26% repeatability and 3.51% reproducibility. Regression analysis demonstrated that patient BMI and height impacted variability in measurements (R2= 16.27). Conclusions: Intra-rater variability for perometer arm measurements diminishes with experience. Gage R&R variability is acceptable per industry standards, but there is room for improvement. Our findings suggest a role for targeted interventions to minimize variability in the diagnosis of BCRL based on patient characteristics.

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