scholarly journals Long-term survival of patients with a history of venous thromboembolism

2011 ◽  
Vol 90 (5) ◽  
pp. 585-594 ◽  
Author(s):  
Sylvia Elisabeth Reitter ◽  
Thomas Waldhoer ◽  
Michaela Mayerhofer ◽  
Ernst Eigenbauer ◽  
Cihan Ay ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Term Survival ◽  
Long Term Survival ◽  
History Of

The influence of thrombophilia on the long-term survival of patients with a history of venous thromboembolism

2013 ◽  
Vol 109 (01) ◽  
pp. 79-84 ◽  
Author(s):  
Sylvia Reitter-Pfoertner ◽  
Thomas Waldhoer ◽  
Michaela Mayerhofer ◽  
Ernst Eigenbauer ◽  
Cihan Ay ◽  
...  
Keyword(s):  
Risk Factors ◽  
Venous Thromboembolism ◽  
Multivariable Analysis ◽  
Factor V Leiden ◽  
Arterial Disease ◽  
Factor V ◽  
Term Survival ◽  
Long Term Survival ◽  
History Of

SummaryData on the long-term survival following venous thromboembolism (VTE) are rare,and the influence of thrombophilia has not been evaluated thus far. Our aim was to assess thrombophilia-parameters as predictors for long-term survival of patients with VTE. Overall, 1,905 outpatients (99 with antithrombin-, protein C or protein S deficiency, 517 with factor V Leiden, 381 with elevated factor VIII and 160 with elevated homocysteine levels, of these 202 had a combination and 961 had none of these risk factors) were included in the study between September 1, 1994 and December 31, 2007. Retrospective survival analysis showed that a total of 78 patients (4.1%) had died during the analysis period, among those four of definite or possible pulmonary embolism and four of bleeding. In multivariable analysis including age and sex an association with increased mortality was found for hyperhomocysteinemia (hazard ratio 2.0 [1.1.-3.5]) whereas this was not the case for all other investigated parameters. We conclude that the classical hereditary thrombophilia risk factors did not have an impact on the long-term survival of patients with a history of VTE. Thus our study supports the current concept that thrombophilia should not be a determinant for decision on long term anticoagulation. However, hyperhomocysteinaemia, known as a risk factor for recurrent VTE and arterial disease, might impact survival.

scholarly journals Long-Term Survival of Patients with a History of Venous Thromboembolism

Blood ◽  
2010 ◽  
Vol 116 (21) ◽  
pp. 3168-3168
Author(s):  
Sylvia Elisabeth Reitter ◽  
Thomas Waldhoer ◽  
Michaela Mayerhofer ◽  
Ernst Eigenbauer ◽  
Cihan Ay ◽  
...  
Keyword(s):  
Venous Thromboembolism ◽  
Survival Rate ◽  
Relative Survival ◽  
Term Survival ◽  
Long Term Survival ◽  
Cumulative Survival ◽  
History Of ◽  
Austrian Population ◽  
Long Term Mortality

Abstract Abstract 3168 Background: Only limited data are available regarding long-term survival following venous thromboembolism (VTE). Objectives: In our study, we aimed to evaluate the long-term mortality rate in patients having a history of deep vein thrombosis (DVT) and/or pulmonary embolism (PE). Patients were referred to our outpatient department for thombophilia testing. We assessed long-term mortality according to the etiology of VTE (spontaneous or following a triggering event) as well as according to the site of thrombosis. In addition, we investigated the relative survival of our patients in comparison to the general Austrian population. Patients/Methods: In our analysis, we included patients with a history of VTE (at least 3 months after a VTE event), who were examined at our out-patient department for routine thrombophilia testing between September 1, 1994 and December 31, 2007. We were provided with information concerning mortality and causes of death of our patients from the Austrian Central Death Registry. The data supplied by Statistics Austria was compared with mortality rates of the general Austrian population, which were also obtained through Statistics Austria. Results: Our study covered a total of 3209 patients (mean age 46.2, range 14–89 years, 1280 men = 40%). The median time interval between the initial occurrence of VTE and study inclusion was 14 months, the median observation period was 6.6 years. During the considered time period (September 1, 1994 and December 31, 2008) a total of 169 patients (5.3%) died, 6 patients died from definite and 2 from probable PE, another 6 patients died from bleeding. The remaining patients died from cancer (34%), cardiovascular causes others than PE (27%) or other diseases (30%). The cumulative survival rate of patients was 0.97 and 0.87 after 5 and 10 years, respectively, the death rate in men was higher than that of the women and the survival of patients with idiopathic VTE was lowest in comparison to those having a triggering event. When patients were compared to the general population, the cumulative relative survival was 1.02 (95% CI 1.00–1.03). In none of the analysed subgroups a reduced cumulative relative survival rate among our patients was noted. Male patients showed a tendency for a better relative survival (1.05, 95 % CI 1.03 – 1.08), whereas that of women (1.00, 95 % CI 0.98 – 1.01) equalled that of the normal population. Duration of anticoagulation (less than 6 months in comparison to more than 18 months after first VTE) did not have an influence on the cumulative survival rates (p = 0.96). Conclusion: Our findings indicate that after the critical initial period, VTE does not seem to have an impact on long-term survival of outpatients with a history of VTE without active malignancy. This is most likely due to the currently prevailing improved diagnostic and treatment modalities of recurrent VTE, which have proved to be most effective and safe. Disclosures: No relevant conflicts of interest to declare.

scholarly journals Long-term outcomes in patients with critical limb ischemia and heart failure with preserved or reduced ejection fraction

2017 ◽  
Vol 22 (4) ◽  
pp. 307-315 ◽  
Author(s):  
Kavita B Khaira ◽  
Ellen Brinza ◽  
Gagan D Singh ◽  
Ezra A Amsterdam ◽  
Stephen W Waldo ◽  
...  
Keyword(s):  
Heart Failure ◽  
Ejection Fraction ◽  
Critical Limb Ischemia ◽  
Limb Ischemia ◽  
Left Ventricular ◽  
Term Survival ◽  
Long Term Survival ◽  
Reduced Ejection Fraction ◽  
History Of

The impact of heart failure (HF) on long-term survival in patients with critical limb ischemia (CLI) has not been well described. Outcomes stratified by left ventricular ejection fraction (EF) are also unknown. A single center retrospective chart review was performed for patients who underwent treatment for CLI from 2006 to 2013. Baseline demographics, procedural data and outcomes were analyzed. HF diagnosis was based on appropriate signs and symptoms as well as results of non-invasive testing. Among 381 CLI patients, 120 (31%) had a history of HF and 261 (69%) had no history of heart failure (no-HF). Within the HF group, 74 (62%) had HF with preserved ejection fraction (HFpEF) and 46 (38%) had HF with reduced ejection fraction (HFrEF). The average EF for those with no-HF, HFpEF and HFrEF were 59±13% vs 56±9% vs 30±9%, respectively. The likelihood of having concomitant coronary artery disease (CAD) was lowest in the no-HF group (43%), higher in the HFpEF group (70%) and highest in the HFrEF group (83%) ( p=0.001). Five-year survival was on average twofold higher in the no-HF group (43%) compared to both the HFpEF (19%, p=0.001) and HFrEF groups (24%, p=0.001). Long-term survival rates did not differ between the two HF groups ( p=0.50). There was no difference in 5-year freedom from major amputation or freedom from major adverse limb events between the no-HF, HFpEF and HFrEF groups, respectively. Overall, the combination of CLI and HF is associated with poor 5-year survival, independent of the degree of left ventricular systolic dysfunction.

Does a History of Malignancy Affect Long-Term Survival in Heart Transplant Recipients?

2017 ◽  
Vol 36 (4) ◽  
pp. S226
Author(s):  
Y. Ravi ◽  
E.M. Stock ◽  
S.K. Lella ◽  
J.V. Balasubramaniyan ◽  
L.A. Nikloidis ◽  
...  
Keyword(s):  
Heart Transplant ◽  
Transplant Recipients ◽  
Term Survival ◽  
Long Term Survival ◽  
History Of ◽  
Heart Transplant Recipients

Long-term Survival of Older Australian Women with a History of Stroke

2015 ◽  
Vol 24 (1) ◽  
pp. 53-60 ◽  
Author(s):  
Julie E. Byles ◽  
Jerryl Lynn Francis ◽  
Catherine L. Chojenta ◽  
Isobel J. Hubbard
Keyword(s):  
Term Survival ◽  
Long Term Survival ◽  
History Of

scholarly journals T stage and venous invasion are crucial prognostic factors for long-term survival of patients with remnant gastric cancer: a cohort study

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Kentaro Matsuo ◽  
Sang-Woong Lee ◽  
Ryo Tanaka ◽  
Yoshiro Imai ◽  
Kotaro Honda ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Survival Rate ◽  
Venous Invasion ◽  
Long Term Outcomes ◽  
Term Survival ◽  
Long Term Survival ◽  
Factors Associated ◽  
T Stage ◽  
History Of

Abstract Background The incidence of remnant gastric cancer (RGC) after distal gastrectomy is 1–5%. However, as the survival rate of patients with gastric cancer improves due to early detection and treatment, more patients may develop RGC. There is no consensus on the surgical and postoperative management of RGC, and the clinicopathological characteristics correlated with the long-term outcomes remain unclear. Therefore, we investigated the clinicopathological factors associated with the long-term outcomes of RGC. Methods We included 65 consecutive patients who underwent gastrectomy for RGC from January 2000 to December 2015 at the Osaka Medical and Pharmaceutical University Hospital, Japan. The Kaplan–Meier method was used to create survival curves, and differences in survival were compared between the groups (clinical factors, pathological factors, and surgical factors) using the log-rank test. Multivariate analyses using the Cox proportional hazard model were used to identify factors associated with long-term survival. Results No significant differences were noted in the survival rate based on clinical factors (age, body mass index, diabetes mellitus, hypertension, cardiovascular disease, pulmonary complications, liver disease, diet, history of alcohol drinking, and history of smoking) or the type of remnant gastrectomy. Significant differences were noted in the survival rate based on pathological factors and surgical characteristics (intraoperative blood loss, operation time, and the number of positive lymph nodes). Multivariate analysis revealed that the T stage (hazard ratio, 5.593; 95% confidence interval [CI], 1.183–26.452; p = 0.030) and venous invasion (hazard ratio, 3.351; 95% CI, 1.030–10.903; p = 0.045) were significant independent risk factors for long-term survival in patients who underwent radical resection for RGC. Conclusions T stage and venous invasion are important prognostic factors of long-term survival after remnant gastrectomy for RGC and may be keys to managing and identifying therapeutic strategies for improving prognosis in RGC.

scholarly journals Extraskeletal Myxoid Chondrosarcoma: Long-Term Survival in the Setting of Metastatic Disease

2020 ◽  
Vol 2020 ◽  
pp. 1-4
Author(s):  
Karim Masrouha ◽  
Iqbal Multani ◽  
Om Bhatt ◽  
Michelle Ghert
Keyword(s):  
Pulmonary Metastases ◽  
Extraskeletal Myxoid Chondrosarcoma ◽  
Term Survival ◽  
Long Term Survival ◽  
Myxoid Chondrosarcoma ◽  
Systemic Intervention ◽  
Slow Progression ◽  
Close Observation ◽  
History Of

Three cases of extraskeletal myxoid chondrosarcoma (EMC) in patients who presented with pulmonary metastases and were managed with long-term close observation without systemic intervention are presented. Follow-up imaging showed slow progression of their disease over several years, and the patients remained asymptomatic from their pulmonary metastases. This clinical experience provides insight into the natural history of the disease and suggests that some patients may experience long-term survival and remain asymptomatic even without systemic intervention, thereby improving their quality of life by avoiding potentially debilitating treatments.

Pteridophyte success and past biota—a palaeobotanist's approach

1985 ◽  
Vol 86 ◽  
pp. 423-430
Author(s):  
B. A. Thomas
Keyword(s):  
Fossil Record ◽  
Geological History ◽  
Term Survival ◽  
Long Term Survival ◽  
Amount Of Information ◽  
The Past ◽  
History Of

SynopsisThe success of plants which lived in the past should be assessed differently from that of living plants as time is an additional important factor. Success may therefore be judged in one period of time or throughout the whole geological history of the plants.Limitations of the fossil record through plant fragmentation, lack of preservation and incomplete preservation severely restrict the amount of information available. However, accepting these problems, there are four major ways in which plants may be judged: long term survival, repeated specialisation, dominance and adaptability. Examples are given of pteridophytes that exhibit success in these four ways.

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