Is the epicardial adipose tissue area on non-ECG gated low-dose chest CT useful for predicting coronary atherosclerosis in an asymptomatic population considered for lung cancer screening?

2018 ◽  
Vol 29 (2) ◽  
pp. 932-940 ◽  
Author(s):  
Kyu-Chong Lee ◽  
Hwan Seok Yong ◽  
Jaewook Lee ◽  
Eun-young Kang ◽  
Jin Oh Na
Keyword(s):  
Lung Cancer ◽  
Adipose Tissue ◽  
Cancer Screening ◽  
Coronary Atherosclerosis ◽  
Low Dose ◽  
Epicardial Adipose Tissue ◽  
Lung Cancer Screening ◽  
Chest Ct ◽  
Tissue Area

scholarly journals P2.11-16 Variability in Reading Low-Dose Chest CT: Individual Readers vs. Central Review in a Nationwide Lung Cancer Screening Project

2019 ◽  
Vol 14 (10) ◽  
pp. S798-S799
Author(s):  
E.J. Hwang ◽  
J.M. Goo ◽  
S.H. Yoon ◽  
H.Y. Kim ◽  
Y. Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Screening ◽  
Low Dose ◽  
Lung Cancer Screening ◽  
Chest Ct

scholarly journals Cardiac visceral fat volume estimation from low-dose chest computed tomography: a study with a designed beating heart phantom

2021 ◽  
Vol 49 (1) ◽  
pp. 61-71
Author(s):  
V. Yu. Chernina ◽  
N. S. Kulberg ◽  
O. O. Aleshina ◽  
T. A. Korb ◽  
I. A. Blokhin ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Lung Cancer ◽  
Adipose Tissue ◽  
Cancer Screening ◽  
Low Dose ◽  
Lung Cancer Screening ◽  
Coronary Calcium ◽  
Stage I ◽  
Stage Ii ◽  
Contracting Heart

Background: Since 2017, a pilot project for lung cancer screening by chest low dose computed tomography (LDCT) has been implemented in Moscow. Patients to be included into the screening have risk factors for ischemic heart disease (IHD). The association between epicardial adipose tissue (EAT) volume and coronary artery atherosclerosis, IHD, and atrial fibrillation has been demonstrated previously.Aim: To demonstrate the feasibility of LDCTbased EAT volumetry using a  dynamic (contracting) heart phantom.Materials and methods: The study was performed with the designed dynamic heart phantom and chest phantom in two stages. At stage I, two adipose tissue pieces were scanned inside and outside the chest phantom using CT and LDCT. At stage II, the dynamic heart phantom was scanned outside and inside the chest phantom. In addition, we scanned the heart phantom with a  coronary calcium phantom. The contracting heart phantom was developed within three months. All scans of the phantom were performed within one day. We determined the adipose tissue thresholds in LDCT and the EAT volumetric error with both chest CT and LDCT. Measurements of the adipose tissue volumes were performed by the radiologist twice with semi-automatic software.Results: The results of stage I helped to identify optimal density thresholds for LDCT-based adipose tissue volumetry in lung cancer screening, ranging from -250 HU to -30 HU. The stage II results showed that for all heart phantom scanning variants, the average EAT volumetry error did not exceed 5%, except for the case of contracting heart phantom with added coronary calcium in a chest phantom with body mass index (BMI) 29 (-5.92%). Adding the coronary calcium phantom to the heart phantom in LDCT increased the error by an average of 4% in BMI 23 and BMI 29 chest phantoms.Conclusion: LDCT-based EAT volumetry with fat density threshold from -250 HU to -30 HU is feasible in lung cancer screening, including patients with coronary calcium. However, considering the phantom design, further patient studies, and correlation of EAT volumes between LDCT for lung cancer screening and сoronary CT angiography are required.

Lung cancer screening in high-risk individuals with annual low-dose chest CT in a community setting.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e12529-e12529
Author(s):  
Niraj K. Gupta ◽  
Richard K Freeman ◽  
Susan Storey ◽  
Dave Reeves ◽  
Anthony Ascioti ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Screening ◽  
High Risk ◽  
Low Dose ◽  
Community Setting ◽  
Lung Cancer Screening ◽  
Chest Ct

scholarly journals LUCSO-1—French pilot study of LUng Cancer Screening with low-dose computed tomography in a smokers population exposed to Occupational lung carcinogens: study protocol

BMJ Open ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. e025026
Author(s):  
Fleur Delva ◽  
François Laurent ◽  
Christophe Paris ◽  
Milia Belacel ◽  
Patrick Brochard ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cancer Screening ◽  
High Risk ◽  
Low Dose ◽  
Lung Cancer Screening ◽  
Chest Ct ◽  
Risk Level ◽  
International Agency ◽  
Occupationally Exposed

IntroductionGuidelines concerning the follow-up of subjects occupationally exposed to lung carcinogens, published in France in 2015, recommended the setting up of a trial of low-dose chest CT lung cancer screening in subjects at high risk of lung cancer.ObjectiveTo evaluate the organisation of low-dose chest CT lung cancer screening in subjects occupationally exposed to lung carcinogens and at high risk of lung cancer.Methods and analysisThis trial will be conducted in eight French departments by six specialised reference centres (SRCs) in occupational health. In view of the exploratory nature of this trial, it is proposed to test initially the feasibility and acceptability over the first 2 years in only two SRCs then in four other SRCs to evaluate the organisation. The target population is current or former smokers with more than 30 pack-years (who have quit smoking for less than 15 years), currently or previously exposed to International Agency for Research on Cancer group 1 lung carcinogens, and between the ages of 55 and 74 years. The trial will be conducted in the following steps: (1) identification of subjects by a screening invitation letter; (2) evaluation of occupational exposure to lung carcinogens; (3) evaluation of the lung cancer risk level and verification of eligibility; (4) screening procedure: annual chest CT scans performed by specialised centres and (5) follow-up of CT scan abnormalities.Ethics and disseminationThis protocol study has been approved by the French Committee for the Protection of Persons. The results from this study will be submitted to peer-reviewed journals and reported at suitable national and international meetings.Trial registration numberNCT03562052; Pre-results.

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