Functional MRI of the brain: localisation of eloquent cortex in focal brain lesion therapy

1998 ◽  
Vol 8 (9) ◽  
pp. 1573-1580 ◽  
Author(s):  
S. Dymarkowski ◽  
S. Sunaert ◽  
S. Van Oostende ◽  
P. Van Hecke ◽  
G. Wilms ◽  
...  
Neuroreport ◽  
2001 ◽  
Vol 12 (7) ◽  
pp. 1335-1340 ◽  
Author(s):  
Giovanni Cioni ◽  
Domenico Montanaro ◽  
Michela Tosetti ◽  
Raffaello Canapicchi ◽  
Brunello Ghelarducci

Author(s):  
Mariko Nakata ◽  
Masayuki Shimoda ◽  
Shinya Yamamoto

Abstract Irradiation with ultraviolet (UV) light on the cortical surface can induce a focal brain lesion (UV lesion) in rodents. In the present study, we investigated the process of establishing a UV lesion. Rats underwent UV irradiation (365 nm wavelength, 2.0 mWh) over the dura, and time-dependent changes in the cortical tissue were analyzed histologically. We found that the majority of neurons in the lesion started to degenerate within 24 hours and the rest disappeared within 5 days after irradiation. UV-induced neuronal degeneration progressed in a layer-dependent manner. Moreover, UV-induced terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) positivity and heme oxygenase-1 (HO-1) immunoreactivity were also detected. These findings suggest that UV irradiation in the brain can induce gradual neural degeneration and oxidative stress. Importantly, UV vulnerability may vary among cortical layers. UV-induced cell death may be due to apoptosis; however, there remains a possibility that UV-irradiated cells were degenerated via processes other than apoptosis. The UV lesion technique will not only assist in investigating brain function at a targeted site but may also serve as a pathophysiological model of focal brain injury and/or neurodegenerative disorders.


2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Yuejiao Li ◽  
Yankai Dong ◽  
Ye Ran ◽  
Yanan Zhang ◽  
Boyao Wu ◽  
...  

Abstract Background We show previously that three-dimensional (3D) spheroid cultured mesenchymal stem cells (MSCs) exhibit reduced cell size thus devoid of lung entrapment following intravenous (IV) infusion. In this study, we determined the therapeutic effect of 3D-cultured MSCs on ischemic stroke and investigated the mechanisms involved. Methods Rats underwent middle cerebral artery occlusion (MCAO) and reperfusion. 1 × 106 of 3D- or 2D-cultured MSCs, which were pre-labeled with GFP, were injected through the tail vain three and seven days after MCAO. Two days after infusion, MSC engraftment into the ischemic brain tissues was assessed by histological analysis for GFP-expressing cells, and infarct volume was determined by MRI. Microglia in the lesion were sorted and subjected to gene expressional analysis by RNA-seq. Results We found that infusion of 3D-cultured MSCs significantly reduced the infarct volume of the brain with increased engraftment of the cells into the ischemic tissue, compared to 2D-cultured MSCs. Accordingly, in the brain lesion of 3D MSC-treated animals, there were significantly reduced numbers of amoeboid microglia and decreased levels of proinflammatory cytokines, indicating attenuated activation of the microglia. RNA-seq of microglia derived from the lesions suggested that 3D-cultured MSCs decreased the response of microglia to the ischemic insult. Interestingly, we observed a decreased expression of mincle, a damage-associated molecular patterns (DAMPs) receptor, which induces the production of proinflammatory cytokines, suggestive of a potential mechanism in 3D MSC-mediated enhanced repair to ischemic stroke. Conclusions Our data indicate that 3D-cultured MSCs exhibit enhanced repair to ischemic stroke, probably through a suppression to ischemia-induced microglial activation.


2018 ◽  
Vol 119 (6) ◽  
pp. 2256-2264 ◽  
Author(s):  
Zarrar Shehzad ◽  
Gregory McCarthy

Whether category information is discretely localized or represented widely in the brain remains a contentious issue. Initial functional MRI studies supported the localizationist perspective that category information is represented in discrete brain regions. More recent fMRI studies using machine learning pattern classification techniques provide evidence for widespread distributed representations. However, these latter studies have not typically accounted for shared information. Here, we find strong support for distributed representations when brain regions are considered separately. However, localized representations are revealed by using analytical methods that separate unique from shared information among brain regions. The distributed nature of shared information and the localized nature of unique information suggest that brain connectivity may encourage spreading of information but category-specific computations are carried out in distinct domain-specific regions. NEW & NOTEWORTHY Whether visual category information is localized in unique domain-specific brain regions or distributed in many domain-general brain regions is hotly contested. We resolve this debate by using multivariate analyses to parse functional MRI signals from different brain regions into unique and shared variance. Our findings support elements of both models and show information is initially localized and then shared among other regions leading to distributed representations being observed.


2011 ◽  
Vol 0 (1) ◽  
pp. 15-22
Author(s):  
Lyudmila Dzyak ◽  
Mykola Zorin ◽  
Andriy Sirko ◽  
Ihor Kirpa ◽  
N. Okunevych ◽  
...  

2015 ◽  
Vol 58 (7) ◽  
pp. 735-742 ◽  
Author(s):  
Katrijn Klingels ◽  
Ellen Jaspers ◽  
Martin Staudt ◽  
Andrea Guzzetta ◽  
Lisa Mailleux ◽  
...  

PEDIATRICS ◽  
1958 ◽  
Vol 22 (2) ◽  
pp. 319-328
Author(s):  
L. W. Falkinburg ◽  
M. L. Silver ◽  
M. N. Kay ◽  
J. Stoll

A case of Sturge-Weber's disease, confirmed by necropsy, in a female 2 3/12 years old, is presented. This case, aside from its rarity, is noteworthy in that it is confirmed by necropsy, that the facial lesion is bilateral while the brain lesion is unilateral, and that there is an unusual amount of mineral deposit in the brain considering the short duration of the disease. A general review of this interesting condition is presented. As far as we have been able to tell, this case is the eighteenth confirmed case of Sturge-Weber's disease recorded in the American literature.


2019 ◽  
pp. 451-478
Author(s):  
Stanley Finger

Gall remained a controversial figure throughout his life, which ended in Paris in 1828. In his later years, he continued to fight with Georges Cuvier, who had overseen the rejection of his and Spurzheim’s Mémoire to the Institut National in 1808, and with Cuvier’s protégé, physiologist Pierre Flourens. Flourens initially looked favorably on Gall’s doctrine, but during the 1820s his brain lesion experiments on birds and other animals were heralded by the French élite as strong evidence against cortical localization of function. Despite this formidable opposition, Gall did find a supporter of localization of function in physician Jean-Baptiste Bouillaud, who started reporting in 1825 that lesions of the anterior part of the brain are more likely to affect speech than posterior brain damage. Gall’s health began to fail a year later, when he was 68 and began to have strokes. After he succumbed to a cerebral hemorrhage in 1828, his body was buried in Paris’ Cimetiére du Pére-Lachaise, but not his skull, which was examined by his followers and added to his collection. Gall’s organologie, now regarded as phrénologie, now began an even steeper decline in France and throughout the Continent, although “popular phrenology,” with less emphasis on the underlying science, continued to be influential on British and American landscapes.


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