Association between coronary artery calcium score on non-contrast chest computed tomography and all-cause mortality among patients with congestive heart failure

2021 ◽  
Author(s):  
Kyoko Ota ◽  
Rine Nakanishi ◽  
Hidenobu Hashimoto ◽  
Yuriko Okamura ◽  
Ippei Watanabe ◽  
...  
Keyword(s):  
Heart Failure ◽  
Computed Tomography ◽  
Congestive Heart Failure ◽  
Coronary Artery ◽  
Coronary Artery Calcium ◽  
Coronary Artery Calcium Score ◽  
Calcium Score ◽  
Chest Computed Tomography ◽  
All Cause Mortality

scholarly journals Prognostic Values of Coronary Artery Calcium Score and 123I-BMIPP SPECT In Patients With Non-Ischemic Heart Failure With Preserved Ejection Fraction

2021 ◽  
Author(s):  
Hidenobu Hashimoto ◽  
Rine Nakanishi ◽  
Sunao Mizumura ◽  
Yukiko Hashimoto ◽  
Yuriko Okamura ◽  
...  
Keyword(s):  
Heart Failure ◽  
Computed Tomography ◽  
Coronary Artery ◽  
Ejection Fraction ◽  
Coronary Artery Calcium ◽  
Coronary Artery Calcium Score ◽  
Calcium Score ◽  
Ischemic Heart ◽  
Preserved Ejection Fraction ◽  
Ischemic Heart Failure

Abstract Purpose This study aimed to determine whether coronary artery calcium score (CACS) can be a prognostic indicator for the development of major adverse cardiac events (MACEs) and compare the value of CACS with that of the 123I-betamethyl-p-iodophenyl-pentadecanoic acid (123I-BMIPP) defect score (BDS) in patients with non-ischemic heart failure with preserved ejection fraction (NIHFpEF). Methods Among 643 consecutive patients hospitalized due to acute heart failure, 108 (74 ± 13y) were identified to have NIHFpEF on non-contrast regular chest computed tomography and 123I-BMIPP single-photon emission computed tomography (SPECT). We evaluated whether CACS and BDS were associated with MACEs using multivariate Cox models. Results Thirty-two MACEs developed at a mean follow-up period of 2.4 years. Higher CACS (hazard ratio [HR] 2.27, 95% confidence interval [CI] 1.10–4.67) and higher BDS (HR 22.14, 95% CI 7.95–61.60) were significantly associated with the development of MACEs. Patients showing higher CACS and BDS carried a significantly higher risk for developing MACE (HR 23.65, 95% CI 10.33–54.13, p < 0.001). Conclusion CACS, as well as BDS, could serve as potential prognostic indicators in patients with NIHFpEF.

scholarly journals Gender Differences in the Atherosclerosis Profile by Coronary CTA in Coronary Artery Calcium Score Zero Patients

2021 ◽  
Vol 10 (6) ◽  
pp. 1220
Author(s):  
Thomas Senoner ◽  
Fabian Plank ◽  
Christoph Beyer ◽  
Christian Langer ◽  
Katharina Birkl ◽  
...  
Keyword(s):  
Gender Differences ◽  
Coronary Artery ◽  
Cardiovascular Mortality ◽  
Coronary Artery Calcium ◽  
Coronary Artery Calcium Score ◽  
Calcium Score ◽  
Plaque Burden ◽  
Term Outcome ◽  
Long Term Outcome ◽  
All Cause Mortality

Background: The coronary artery calcium score (CACS) is a powerful tool for cardiovascular risk stratification. Coronary computed tomography angiography (CTA) allows for a more distinct analysis of atherosclerosis. The aim of the study was to assess gender differences in the atherosclerosis profile of CTA in patients with a CACS of zero. Methods: A total of 1451 low- to intermediate-risk patients (53 ± 11 years; 51% females) with CACS <1.0 Agatston units (AU) who underwent CTA and CACS were included. Males and females were 1:1 propensity score-matched. CTA was evaluated for stenosis severity (Coronary Artery Disease – Reporting and Data System (CAD-RADS) 0–5: minimal <25%, mild 25–49%, moderate 50–69%, severe ≥70%), mixed-plaque burden (G-score), and high-risk plaque (HRP) criteria (low-attenuation plaque, spotty calcification, napkin-ring sign, and positive remodeling). All-cause mortality, cardiovascular mortality, and major cardiovascular events (MACEs) were collected. Results: Among the patients, 88.8% had a CACS of 0 and 11.2% had an ultralow CACS of 0.1–0.9 AU. More males than females (32.1% vs. 20.3%; p < 0.001) with a CACS of 0 had atherosclerosis, while, among those with an ultralow CACS, there was no difference (88% vs. 87.1%). Nonobstructive CAD (25.9% vs. 16.2%; p < 0.001), total plaque burden (2.2 vs. 1.4; p < 0.001), and HRP were found more often in males (p < 0.001). After a follow-up of mean 6.6 ± 4.2 years, all-cause mortality was higher in females (3.5% vs. 1.8%, p = 0.023). Cardiovascular mortality and MACEs were low (0.2% vs. 0%; p = 0.947 and 0.3% vs. 0.6%; p = 0.790) for males vs. females, respectively. Females were more often symptomatic for chest pain (70% vs. 61.6%; p = 0.004). (4) Conclusions: In patients with a CACS of 0, males had a higher prevalence of atherosclerosis, a higher noncalcified plaque burden, and more HRP criteria. Nonetheless, females had a worse long–term outcome and were more frequently symptomatic.

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